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    ILK integrin linked kinase [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 709944, updated on 8-Dec-2024

    Summary

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    Official Symbol
    ILKprovided by VGNC
    Official Full Name
    integrin linked kinaseprovided by VGNC
    Primary source
    VGNC:VGNC:73738
    Locus tag
    EGK_06531
    See related
    Ensembl:ENSMMUG00000007741
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See ILK in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 14 NC_041767.1 (59329312..59336462, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 14 NC_027906.1 (60169607..60176732, complement)

    Chromosome 14 - NC_041767.1Genomic Context describing neighboring genes Neighboring gene dachsous cadherin-related 1 Neighboring gene tripeptidyl peptidase 1 Neighboring gene TATA-box binding protein associated factor 10 Neighboring gene ribosomal RNA processing 8 Neighboring gene dynein heavy chain domain 1 Neighboring gene uncharacterized LOC114672346

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analysis of the Macaca mulatta transcriptome and the sequence divergence between Macaca and human. Magness CL, et al. Genome Biol, 2005. PMID 15998449, Free PMC Article
    2. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol, 2011 Oct 16. PMID 22002653
    3. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in integrin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in substrate adhesion-dependent cell spreading IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in stress fiber IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    scaffold protein ILK; integrin-linked protein kinase
    Names
    Integrin-linked protein kinase
    NP_001182642.1
    XP_014970232.1
    XP_014970233.1
    XP_014970235.1
    XP_028688492.1
    XP_028688493.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001195713.1 → NP_001182642.1  scaffold protein ILK

      See identical proteins and their annotated locations for NP_001182642.1

      Status: VALIDATED

      Source sequence(s)
      CN648229, CN648333, CN648584, CN648665, CO646514
      UniProtKB/TrEMBL
      A0A1D5R4A2, A0A8J8YHP8, F7C2W0, G7NE06
      Related
      ENSMMUP00000055138.2, ENSMMUT00000066962.2
      Conserved Domains (4) summary
      cd14057
      Location:197 → 449
      PK_ILK; Pseudokinase domain of Integrin Linked Kinase
      sd00045
      Location:33 → 64
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:4 → 54
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:38 → 124
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041767.1 Reference Mmul_10 Primary Assembly

      Range
      59329312..59336462 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015114746.2 → XP_014970232.1  integrin-linked protein kinase isoform X1

      UniProtKB/TrEMBL
      A0A1D5R4A2
      Conserved Domains (3) summary
      cd00204
      Location:28 → 140
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd14057
      Location:227 → 479
      PK_ILK; Pseudokinase domain of Integrin Linked Kinase
      sd00045
      Location:33 → 64
      ANK; ANK repeat [structural motif]

    2. XM_015114747.2 → XP_014970233.1  integrin-linked protein kinase isoform X2

      UniProtKB/TrEMBL
      A0A1D5R4A2, A0A8J8YHP8, F7C2W0, G7NE06
      Related
      ENSMMUP00000010171.4, ENSMMUT00000010842.4
      Conserved Domains (4) summary
      cd14057
      Location:197 → 449
      PK_ILK; Pseudokinase domain of Integrin Linked Kinase
      sd00045
      Location:33 → 64
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:4 → 54
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:38 → 124
      Ank_2; Ankyrin repeats (3 copies)

    3. XM_015114749.2 → XP_014970235.1  integrin-linked protein kinase isoform X5

      UniProtKB/TrEMBL
      A0A5F8AAX1
      Related
      ENSMMUP00000074120.1, ENSMMUT00000105924.1
      Conserved Domains (1) summary
      cd14057
      Location:63 → 315
      PK_ILK; Pseudokinase domain of Integrin Linked Kinase

    4. XM_028832660.1 → XP_028688493.1  integrin-linked protein kinase isoform X4

      UniProtKB/TrEMBL
      A0A1D5R4A2, A0A1D5R971
      Related
      ENSMMUP00000056862.2, ENSMMUT00000075329.2
      Conserved Domains (3) summary
      cd14057
      Location:146 → 398
      PK_ILK; Pseudokinase domain of Integrin Linked Kinase
      sd00045
      Location:15 → 46
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:2 → 73
      Ank_2; Ankyrin repeats (3 copies)

    5. XM_028832659.1 → XP_028688492.1  integrin-linked protein kinase isoform X3

      UniProtKB/TrEMBL
      A0A1D5R325, A0A1D5R4A2
      Related
      ENSMMUP00000054710.2, ENSMMUT00000061319.2
      Conserved Domains (3) summary
      cd14057
      Location:185 → 437
      PK_ILK; Pseudokinase domain of Integrin Linked Kinase
      sd00045
      Location:21 → 52
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:26 → 112
      Ank_2; Ankyrin repeats (3 copies)
    Nucleotide Protein
    Heading Accession and Version

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