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    PDE4B phosphodiesterase 4B [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 699309, updated on 17-Aug-2024

    Summary

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    Official Symbol
    PDE4Bprovided by VGNC
    Official Full Name
    phosphodiesterase 4Bprovided by VGNC
    Primary source
    VGNC:VGNC:75916
    Locus tag
    EGK_00854
    See related
    Ensembl:ENSMMUG00000007490
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See PDE4B in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 1 NC_041754.1 (158052092..158636361, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 1 NC_027893.1 (65538807..66139739)

    Chromosome 1 - NC_041754.1Genomic Context describing neighboring genes Neighboring gene dynein light chain Tctex-type family member 5 Neighboring gene SH3GL interacting endocytic adaptor 1 Neighboring gene uncharacterized LOC106999119 Neighboring gene uncharacterized LOC106999122 Neighboring gene U4 spliceosomal RNA Neighboring gene polypeptide N-acetylgalactosaminyltransferase 11-like Neighboring gene small nucleolar RNA U13 Neighboring gene leptin receptor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 3',5'-cyclic-AMP phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transmembrane transporter binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    3',5'-cyclic-AMP phosphodiesterase 4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B
    Names
    phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)
    NP_001252893.1
    XP_014996872.1
    XP_014996877.1
    XP_014996888.1
    XP_028688805.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001265964.1 → NP_001252893.1  3',5'-cyclic-AMP phosphodiesterase 4B

      See identical proteins and their annotated locations for NP_001252893.1

      Status: PROVISIONAL

      Source sequence(s)
      JU334885
      UniProtKB/TrEMBL
      F6QKH9
      Related
      ENSMMUP00000009842.2, ENSMMUT00000010489.4
      Conserved Domains (2) summary
      pfam00233
      Location:390 → 631
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:151 → 266
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041754.1 Reference Mmul_10 Primary Assembly

      Range
      158052092..158636361 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015141386.2 → XP_014996872.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1

      UniProtKB/TrEMBL
      A0A8J8Y9Y9, F6QKI6, G7MHI2
      Conserved Domains (2) summary
      pfam00233
      Location:405 → 646
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:166 → 281
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

    2. XM_015141391.2 → XP_014996877.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1

      UniProtKB/TrEMBL
      A0A8J8Y9Y9, F6QKI6, G7MHI2
      Related
      ENSMMUP00000009841.1, ENSMMUT00000010488.3
      Conserved Domains (2) summary
      pfam00233
      Location:405 → 646
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:166 → 281
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

    3. XM_028832972.1 → XP_028688805.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X2

      UniProtKB/TrEMBL
      F6QKG3, H9ENB9
      Related
      ENSMMUP00000009843.3, ENSMMUT00000010490.4
      Conserved Domains (2) summary
      pfam00233
      Location:186 → 427
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:1 → 62
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

    4. XM_015141402.2 → XP_014996888.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X3

      UniProtKB/TrEMBL
      A0A1D5R2V8, F6QKG3, H9ENB9
      Related
      ENSMMUP00000054643.1, ENSMMUT00000078513.2
      Conserved Domains (2) summary
      pfam00233
      Location:172 → 413
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:16 → 48
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
    Nucleotide Protein
    Heading Accession and Version

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