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    PTPRU protein tyrosine phosphatase receptor type U [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 720393, updated on 17-Aug-2024

    Summary

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    Official Symbol
    PTPRUprovided by VGNC
    Official Full Name
    protein tyrosine phosphatase receptor type Uprovided by VGNC
    Primary source
    VGNC:VGNC:76624
    See related
    Ensembl:ENSMMUG00000015661
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See PTPRU in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 1 NC_041754.1 (195353356..195444456, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 1 NC_027893.1 (28224965..28316535)

    Chromosome 1 - NC_041754.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC114678304 Neighboring gene uncharacterized LOC106997415 Neighboring gene mitochondrial trans-2-enoyl-CoA reductase Neighboring gene serine and arginine rich splicing factor 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    receptor-type tyrosine-protein phosphatase U
    XP_014988952.2
    XP_014988961.2
    XP_014988970.2
    XP_014988978.2
    XP_014988988.1
    XP_014988995.1
    XP_014988999.1
    XP_014989006.1
    XP_014989014.1
    XP_014989022.1
    XP_014989030.1
    XP_028692876.1
    XP_028692894.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041754.1 Reference Mmul_10 Primary Assembly

      Range
      195353356..195444456 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015133544.2 → XP_014989030.1  receptor-type tyrosine-protein phosphatase U isoform X12

      UniProtKB/TrEMBL
      G7MI12
      Conserved Domains (7) summary
      cd06263
      Location:27 → 186
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      smart00137
      Location:22 → 186
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00194
      Location:1162 → 1425
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:913 → 1130
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:484 → 585
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:291 → 366
      fn3; Fibronectin type III domain
      pfam00102
      Location:908 → 1130
      Y_phosphatase; Protein-tyrosine phosphatase

    2. XM_015133513.2 → XP_014988999.1  receptor-type tyrosine-protein phosphatase U isoform X8

      UniProtKB/TrEMBL
      G7MI12
      Related
      ENSMMUP00000020551.4, ENSMMUT00000021972.4
      Conserved Domains (7) summary
      cd06263
      Location:27 → 186
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      smart00137
      Location:22 → 186
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00194
      Location:1175 → 1438
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:923 → 1143
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:484 → 585
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:291 → 366
      fn3; Fibronectin type III domain
      pfam00102
      Location:918 → 1143
      Y_phosphatase; Protein-tyrosine phosphatase

    3. XM_015133536.2 → XP_014989022.1  receptor-type tyrosine-protein phosphatase U isoform X11

      UniProtKB/TrEMBL
      G7MI12
      Related
      ENSMMUP00000020553.4, ENSMMUT00000021974.4
      Conserved Domains (7) summary
      cd06263
      Location:27 → 186
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      smart00137
      Location:22 → 186
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00194
      Location:1165 → 1428
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:913 → 1133
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:484 → 585
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:291 → 366
      fn3; Fibronectin type III domain
      pfam00102
      Location:908 → 1133
      Y_phosphatase; Protein-tyrosine phosphatase

    4. XM_015133528.2 → XP_014989014.1  receptor-type tyrosine-protein phosphatase U isoform X10

      UniProtKB/TrEMBL
      G7MI12
      Conserved Domains (7) summary
      cd06263
      Location:27 → 186
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      smart00137
      Location:22 → 186
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00194
      Location:1171 → 1434
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:913 → 1139
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:484 → 585
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:291 → 366
      fn3; Fibronectin type III domain
      pfam00102
      Location:908 → 1139
      Y_phosphatase; Protein-tyrosine phosphatase

    5. XM_015133492.2 → XP_014988978.2  receptor-type tyrosine-protein phosphatase U isoform X5

      UniProtKB/TrEMBL
      G7MI12
      Conserved Domains (5) summary
      smart00137
      Location:22 → 186
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      cd00063
      Location:386 → 481
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:494 → 577
      fn3; Fibronectin type III domain
      cd14637
      Location:1246 → 1452
      R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
      cl28904
      Location:933 → 1161
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    6. XM_015133520.2 → XP_014989006.1  receptor-type tyrosine-protein phosphatase U isoform X9

      UniProtKB/TrEMBL
      G7MI12
      Conserved Domains (7) summary
      cd06263
      Location:27 → 186
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      smart00137
      Location:22 → 186
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00194
      Location:1172 → 1435
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:923 → 1140
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:484 → 585
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:291 → 366
      fn3; Fibronectin type III domain
      pfam00102
      Location:918 → 1140
      Y_phosphatase; Protein-tyrosine phosphatase

    7. XM_028837043.1 → XP_028692876.1  receptor-type tyrosine-protein phosphatase U isoform X4

      UniProtKB/TrEMBL
      G7MI12
      Conserved Domains (5) summary
      smart00137
      Location:22 → 186
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      cd00063
      Location:386 → 481
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:494 → 577
      fn3; Fibronectin type III domain
      cd14637
      Location:1247 → 1453
      R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
      cl28904
      Location:943 → 1162
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    8. XM_015133484.2 → XP_014988970.2  receptor-type tyrosine-protein phosphatase U isoform X3

      UniProtKB/TrEMBL
      G7MI12
      Conserved Domains (5) summary
      smart00137
      Location:22 → 186
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      cd00063
      Location:386 → 481
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:494 → 577
      fn3; Fibronectin type III domain
      cd14637
      Location:1250 → 1456
      R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
      cl28904
      Location:943 → 1165
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    9. XM_015133509.2 → XP_014988995.1  receptor-type tyrosine-protein phosphatase U isoform X7

      UniProtKB/TrEMBL
      G7MI12
      Conserved Domains (7) summary
      cd06263
      Location:27 → 186
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      smart00137
      Location:22 → 186
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00194
      Location:1178 → 1441
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:923 → 1146
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:484 → 585
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:291 → 366
      fn3; Fibronectin type III domain
      pfam00102
      Location:918 → 1146
      Y_phosphatase; Protein-tyrosine phosphatase

    10. XM_015133475.2 → XP_014988961.2  receptor-type tyrosine-protein phosphatase U isoform X2

      UniProtKB/TrEMBL
      G7MI12
      Conserved Domains (5) summary
      smart00137
      Location:22 → 186
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      cd00063
      Location:386 → 481
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:494 → 577
      fn3; Fibronectin type III domain
      cd14637
      Location:1253 → 1459
      R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
      cl28904
      Location:943 → 1168
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    11. XM_015133502.2 → XP_014988988.1  receptor-type tyrosine-protein phosphatase U isoform X6

      UniProtKB/TrEMBL
      F6R5G4, G7MI12
      Related
      ENSMMUP00000020563.4, ENSMMUT00000021984.4
      Conserved Domains (7) summary
      cd06263
      Location:27 → 186
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      smart00137
      Location:22 → 186
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00194
      Location:1181 → 1444
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:923 → 1149
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:484 → 585
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:291 → 366
      fn3; Fibronectin type III domain
      pfam00102
      Location:918 → 1149
      Y_phosphatase; Protein-tyrosine phosphatase

    12. XM_015133466.2 → XP_014988952.2  receptor-type tyrosine-protein phosphatase U isoform X1

      UniProtKB/TrEMBL
      G7MI12
      Conserved Domains (5) summary
      smart00137
      Location:22 → 186
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      cd00063
      Location:386 → 481
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:494 → 577
      fn3; Fibronectin type III domain
      cd14637
      Location:1256 → 1462
      R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
      cl28904
      Location:943 → 1171
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    13. XM_028837061.1 → XP_028692894.1  receptor-type tyrosine-protein phosphatase U isoform X13

      UniProtKB/TrEMBL
      G7MI12
      Conserved Domains (5) summary
      smart00137
      Location:1 → 114
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      cd00063
      Location:314 → 409
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:422 → 505
      fn3; Fibronectin type III domain
      cd14637
      Location:1184 → 1390
      R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
      cl28904
      Location:871 → 1099
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    Nucleotide Protein
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