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    BRAF B-Raf proto-oncogene, serine/threonine kinase [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 693554, updated on 5-Mar-2024

    Summary

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    Gene symbol
    BRAF
    Gene description
    B-Raf proto-oncogene, serine/threonine kinase
    See related
    Ensembl:ENSMMUG00000042793
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See BRAF in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 3 NC_041756.1 (167129803..167331819, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 3 NC_027895.1 (167117131..167321349, complement)

    Chromosome 3 - NC_041756.1Genomic Context describing neighboring genes Neighboring gene aarF domain containing kinase 2 Neighboring gene NADH:ubiquinone oxidoreductase subunit B2 Neighboring gene U6 spliceosomal RNA Neighboring gene T-complex protein 1 subunit delta-like Neighboring gene mitochondrial ribosomal protein S33

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine-protein kinase B-raf

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041756.1 Reference Mmul_10 Primary Assembly

      Range
      167129803..167331819 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015135078.2 → XP_014990564.1  serine/threonine-protein kinase B-raf isoform X1

      UniProtKB/TrEMBL
      A0A1D5Q9W4, A0A1D5QI09
      Related
      ENSMMUP00000044832.2, ENSMMUT00000073043.2
      Conserved Domains (4) summary
      cd01816
      Location:152 → 223
      Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
      cd14062
      Location:459 → 711
      STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
      pfam00069
      Location:454 → 709
      Pkinase; Protein kinase domain
      pfam00130
      Location:231 → 276
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    2. XM_015135080.2 → XP_014990566.1  serine/threonine-protein kinase B-raf isoform X2

      UniProtKB/TrEMBL
      A0A5F8A7V3, H9F989
      Related
      ENSMMUP00000073941.1, ENSMMUT00000083203.1
      Conserved Domains (3) summary
      cd14062
      Location:459 → 705
      STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
      cd17134
      Location:150 → 228
      RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
      cd20871
      Location:226 → 285
      C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins

    RNA

    1. XR_001443900.2 RNA Sequence

      Related
      ENSMMUT00000078361.2
    Nucleotide Protein
    Heading Accession and Version

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