SELENOF selenoprotein F [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Official Symbol: SELENOFprovided by VGNC
Official Full Name: selenoprotein Fprovided by VGNC
Primary source: VGNC:VGNC:112161
See related: Ensembl:ENSMMUG00000016554
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Also known as: SEP15
Summary: The protein encoded by this gene belongs to the SEP15/selenoprotein M family. The exact function of this protein is not known; however, it has been found to associate with UDP-glucose:glycoprotein glucosyltransferase (UGTR), an endoplasmic reticulum(ER)-resident protein, which is involved in the quality control of protein folding. The association with UGTR retains this protein in the ER, where it may play a role in protein folding. It has also been suggested to have a role in cancer etiology. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2016]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	1	NC_041754.1 (137598783..137648428)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	1	NC_027893.1 (87019480..87069504, complement)

Chromosome 1 - NC_041754.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

G54091 (e-PCR)
- UniSTS:109328

D1S3349 (e-PCR)
- UniSTS:59938

SHGC-75087 (e-PCR)
- UniSTS:57124

G54028 (e-PCR)
- UniSTS:109410

AL009717 (e-PCR)
- UniSTS:67198

SHGC-32731 (e-PCR)
- UniSTS:41096

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum lumen	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: selenoprotein F

Names: 15 kDa selenoprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001159416.2 → NP_001152888.1 selenoprotein F isoform 1 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the predominant transcript and encodes the longer isoform (1).

Source sequence(s)

JV528708, JV704574, QNVO02000012

UniProtKB/TrEMBL

A0A1D5R8W7

Related

ENSMMUP00000056757.2, ENSMMUT00000078140.2

Conserved Domains (1) summary

pfam08806
Location:88 → 163

Sep15_SelM; Sep15/SelM redox domain
NM_001346968.1 → NP_001333897.1 selenoprotein F isoform 2 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an exon in the 3' coding region, which results in a frameshift compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

JU337415, JV704574, QNVO02000012

UniProtKB/TrEMBL

H9FMP2

RNA

NR_144533.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (3) has an alternate 5' terminal exon compared to variant 1. It is represented as non-coding because it lacks an in-frame ORF.

Source sequence(s)

JV528708, JV704574, QNVO02000012