SRC SRC proto-oncogene, non-receptor tyrosine kinase [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Official Symbol: SRCprovided by VGNC
Official Full Name: SRC proto-oncogene, non-receptor tyrosine kinaseprovided by VGNC
Primary source: VGNC:VGNC:77878
See related: Ensembl:ENSMMUG00000020131
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	10	NC_041763.1 (72626150..72664269)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	10	NC_027902.1 (26661982..26700409, complement)

Chromosome 10 - NC_041763.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

SRC_1807 (e-PCR)
- UniSTS:277768

SRC (e-PCR)
- UniSTS:266007

SHGC-132356 (e-PCR)
- UniSTS:170791

RH71012 (e-PCR)
- UniSTS:77680

RH98828 (e-PCR)
- UniSTS:87438

NoName (e-PCR)
- UniSTS:7066

RH12300 (e-PCR)
- UniSTS:65458

D20S834 (e-PCR), detects polymorphism
- UniSTS:79302

WI-14593 (e-PCR)
- UniSTS:44757

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables growth factor receptor binding	IEA Inferred from Electronic Annotation more info	PubMed
enables non-membrane spanning protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in bone resorption	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in epidermal growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in innate immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of extrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of intrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in osteoclast development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in progesterone receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extrinsic component of cytoplasmic side of plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: proto-oncogene tyrosine-protein kinase Src

Names: v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog

NP_001248263.1

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001261334.1 → NP_001248263.1 proto-oncogene tyrosine-protein kinase Src

See identical proteins and their annotated locations for NP_001248263.1

Status: PROVISIONAL

Source sequence(s)

JV044361

UniProtKB/TrEMBL

A0A1D5QC65, F7FWN9, G7N4W5, I0FJ06

Related

ENSMMUP00000026505.4, ENSMMUT00000028323.4

Conserved Domains (3) summary

cd10365
Location:147 → 247

SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)

cd12008
Location:88 → 143

SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase

cd05071
Location:260 → 536

PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src