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    MDM2 MDM2 proto-oncogene [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 718284, updated on 17-Aug-2024

    Summary

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    Official Symbol
    MDM2provided by VGNC
    Official Full Name
    MDM2 proto-oncogeneprovided by VGNC
    Primary source
    VGNC:VGNC:74692
    Locus tag
    EGK_03911
    See related
    Ensembl:ENSMMUG00000055447
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See MDM2 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 11 NC_041764.1 (68342396..68373237)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 11 NC_027903.1 (67554091..67584963)

    Chromosome 11 - NC_041764.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 35 member E3 Neighboring gene SUZ domain-containing protein 1 pseudogene Neighboring gene probable ribosome biogenesis protein RLP24 pseudogene Neighboring gene uncharacterized LOC107000926 Neighboring gene carboxypeptidase M

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase Mdm2
    Names
    Mdm2 p53 binding protein homolog
    Mdm2, p53 E3 ubiquitin protein ligase homolog
    Mdm2, transformed 3T3 cell double minute 2, p53 binding protein
    NP_001253331.1
    XP_015007663.1
    XP_015007664.1
    XP_015007667.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001266402.1 → NP_001253331.1  E3 ubiquitin-protein ligase Mdm2

      See identical proteins and their annotated locations for NP_001253331.1

      Status: PROVISIONAL

      Source sequence(s)
      JU475633
      UniProtKB/TrEMBL
      A0A5F7ZWN2, F7AKS9, H9FUJ1
      Related
      ENSMMUP00000018645.2, ENSMMUT00000019919.3
      Conserved Domains (3) summary
      cd16783
      Location:441 → 497
      mRING-HC-C2H2C4_MDM2; Modified RING finger, HC subclass (C2H2C4-type), found in E3 ubiquitin-protein ligase MDM2 and similar proteins
      cd17672
      Location:31 → 113
      MDM2; p53-binding domain found in E3 ubiquitin-protein ligase MDM2 and similar proteins
      pfam00641
      Location:306 → 334
      zf-RanBP; Zn-finger in Ran binding protein and others

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041764.1 Reference Mmul_10 Primary Assembly

      Range
      68342396..68373237
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015152181.2 → XP_015007667.1  E3 ubiquitin-protein ligase Mdm2 isoform X2

      Conserved Domains (2) summary
      cd16783
      Location:334 → 390
      mRING-HC-C2H2C4_MDM2; Modified RING finger, HC subclass (C2H2C4-type), found in E3 ubiquitin-protein ligase MDM2 and similar proteins
      pfam00641
      Location:198 → 227
      zf-RanBP; Zn-finger in Ran binding protein and others

    2. XM_015152178.2 → XP_015007664.1  E3 ubiquitin-protein ligase Mdm2 isoform X1

      UniProtKB/TrEMBL
      A0A5F7ZWN2, A0A5F8AU84, A0A8J8YAF0, G7N7L5
      Conserved Domains (3) summary
      cd16783
      Location:435 → 491
      mRING-HC-C2H2C4_MDM2; Modified RING finger, HC subclass (C2H2C4-type), found in E3 ubiquitin-protein ligase MDM2 and similar proteins
      cd17672
      Location:25 → 107
      MDM2; p53-binding domain found in E3 ubiquitin-protein ligase MDM2 and similar proteins
      pfam00641
      Location:299 → 328
      zf-RanBP; Zn-finger in Ran binding protein and others

    3. XM_015152177.2 → XP_015007663.1  E3 ubiquitin-protein ligase Mdm2 isoform X1

      UniProtKB/TrEMBL
      A0A5F7ZWN2, A0A5F8AU84, A0A8J8YAF0, G7N7L5
      Related
      ENSMMUP00000080506.1, ENSMMUT00000107715.1
      Conserved Domains (3) summary
      cd16783
      Location:435 → 491
      mRING-HC-C2H2C4_MDM2; Modified RING finger, HC subclass (C2H2C4-type), found in E3 ubiquitin-protein ligase MDM2 and similar proteins
      cd17672
      Location:25 → 107
      MDM2; p53-binding domain found in E3 ubiquitin-protein ligase MDM2 and similar proteins
      pfam00641
      Location:299 → 328
      zf-RanBP; Zn-finger in Ran binding protein and others
    Nucleotide Protein
    Heading Accession and Version

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