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    PRKCI protein kinase C iota [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 574352, updated on 17-Aug-2024

    Summary

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    Official Symbol
    PRKCIprovided by VGNC
    Official Full Name
    protein kinase C iotaprovided by VGNC
    Primary source
    VGNC:VGNC:84064
    See related
    Ensembl:ENSMMUG00000011222
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See PRKCI in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 2 NC_041755.1 (75155808..75241444)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 2 NC_027894.1 (123484529..123573795, complement)

    Chromosome 2 - NC_041755.1Genomic Context describing neighboring genes Neighboring gene polyhomeotic homolog 3 Neighboring gene U6 spliceosomal RNA Neighboring gene U7 small nuclear RNA Neighboring gene SKI like proto-oncogene Neighboring gene claudin 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Elevated gene expression levels distinguish human from non-human primate brains. Cáceres M, et al. Proc Natl Acad Sci U S A, 2003 Oct 28. PMID 14557539, Free PMC Article
    2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables diacylglycerol-dependent serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein kinase C iota type
    XP_014987118.1
    XP_014987119.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041755.1 Reference Mmul_10 Primary Assembly

      Range
      75155808..75241444
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015131632.2 → XP_014987118.1  protein kinase C iota type isoform X1

      UniProtKB/TrEMBL
      A0A5F7Z9M4, A0A5F7ZX99
      Related
      ENSMMUP00000069262.1, ENSMMUT00000108935.1
      Conserved Domains (4) summary
      cd06404
      Location:120 → 202
      PB1_aPKC; PB1 domain is an essential modular domain of the atypical protein kinase C (aPKC) which in complex with Par6 and Par3 proteins is crucial for establishment of apical-basal polarity of animal cells. PB1 domain is a modular domain mediating specific ...
      smart00220
      Location:348 → 616
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05618
      Location:327 → 690
      STKc_aPKC_iota; Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C iota
      pfam00130
      Location:235 → 287
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    2. XM_015131633.2 → XP_014987119.1  protein kinase C iota type isoform X2

      UniProtKB/TrEMBL
      A0A1D5RJL1, G7MJB3
      Related
      ENSMMUP00000060505.1, ENSMMUT00000075873.2
      Conserved Domains (3) summary
      cd06404
      Location:3 → 79
      PB1_aPKC; PB1 domain is an essential modular domain of the atypical protein kinase C (aPKC) which in complex with Par6 and Par3 proteins is crucial for establishment of apical-basal polarity of animal cells. PB1 domain is a modular domain mediating specific ...
      cd05618
      Location:204 → 567
      STKc_aPKC_iota; Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C iota
      cd20794
      Location:110 → 164
      C1_aPKC; protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) family
    Nucleotide Protein
    Heading Accession and Version

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