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    MET MET proto-oncogene, receptor tyrosine kinase [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 704562, updated on 17-Aug-2024

    Summary

    Official Symbol
    METprovided by VGNC
    Official Full Name
    MET proto-oncogene, receptor tyrosine kinaseprovided by VGNC
    Primary source
    VGNC:VGNC:81472
    Locus tag
    EGK_14061
    See related
    Ensembl:ENSMMUG00000006779
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
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    Genomic context

    See MET in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 3 NC_041756.1 (142897814..143014670)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 3 NC_027895.1 (142227320..142344131)

    Chromosome 3 - NC_041756.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC106997620 Neighboring gene caveolin 1 Neighboring gene U7 small nuclear RNA Neighboring gene U2 spliceosomal RNA Neighboring gene capping actin protein of muscle Z-line subunit alpha 2 Neighboring gene tropomyosin alpha-3 chain pseudogene Neighboring gene suppression of tumorigenicity 7

    Genomic regions, transcripts, and products

    General gene information

    Markers

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    enables semaphorin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    enables transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    part_of semaphorin receptor complex IEA
    Inferred from Electronic Annotation
    more info
    PubMed 

    General protein information

    Preferred Names
    hepatocyte growth factor receptor
    Names
    met proto-oncogene (hepatocyte growth factor receptor)
    XP_014990223.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168629.2NP_001162100.2  hepatocyte growth factor receptor precursor

      Status: VALIDATED

      Source sequence(s)
      QNVO02000313
      UniProtKB/TrEMBL
      F7H1K4, G7MM61
      Related
      ENSMMUP00000008920.3, ENSMMUT00000009490.4
      Conserved Domains (7) summary
      cd11278
      Location:25516
      Sema_MET; The Sema domain, a protein interacting module, of MET (also called hepatocyte growth factor receptor, HGFR)
      smart00423
      Location:519561
      PSI; domain found in Plexins, Semaphorins and Integrins
      smart00429
      Location:838934
      IPT; ig-like, plexins, transcription factors
      cd01179
      Location:657740
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:563656
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd05058
      Location:10821343
      PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
      cl15674
      Location:742837
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041756.1 Reference Mmul_10 Primary Assembly

      Range
      142897814..143014670
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015134737.2XP_014990223.2  hepatocyte growth factor receptor isoform X1

      UniProtKB/TrEMBL
      G7MM61
      Conserved Domains (7) summary
      cd11278
      Location:44535
      Sema_MET; The Sema domain, a protein interacting module, of MET (also called hepatocyte growth factor receptor, HGFR)
      smart00423
      Location:538580
      PSI; domain found in Plexins, Semaphorins and Integrins
      smart00429
      Location:857953
      IPT; ig-like, plexins, transcription factors
      cd01179
      Location:676759
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:582675
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01181
      Location:761856
      IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd05058
      Location:11011362
      PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron