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    TIMP3 TIMP metallopeptidase inhibitor 3 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 574381, updated on 17-Aug-2024

    Summary

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    Official Symbol
    TIMP3provided by VGNC
    Official Full Name
    TIMP metallopeptidase inhibitor 3provided by VGNC
    Primary source
    VGNC:VGNC:108066
    See related
    Ensembl:ENSMMUG00000062825
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See TIMP3 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 10 NC_041763.1 (18645380..18703187, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 10 NC_027902.1 (74706440..74764284)

    Chromosome 10 - NC_041763.1Genomic Context describing neighboring genes Neighboring gene LARGE xylosyl- and glucuronyltransferase 1 Neighboring gene uncharacterized LOC114670368 Neighboring gene uncharacterized LOC114670590 Neighboring gene synapsin III Neighboring gene F-box protein 7 Neighboring gene BPI fold containing family C Neighboring gene RNA 2',3'-cyclic phosphate and 5'-OH ligase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables metalloendopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protease binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of membrane protein ectodomain proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    metalloproteinase inhibitor 3
    Names
    TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory)
    TIMP-3
    tissue inhibitor of metalloproteinase 3
    tissue inhibitor of metalloproteinases 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001032956.1 → NP_001028128.1  metalloproteinase inhibitor 3 precursor

      See identical proteins and their annotated locations for NP_001028128.1

      Status: PROVISIONAL

      Source sequence(s)
      AY821556
      UniProtKB/Swiss-Prot
      Q5PXZ9
      UniProtKB/TrEMBL
      G1K371, H9FZ31
      Related
      ENSMMUP00000067268.1, ENSMMUT00000097441.1
      Conserved Domains (1) summary
      cd03585
      Location:24 → 200
      NTR_TIMP; NTR domain, TIMP subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential regulators of extracellular matrix turnover and remodeling. They form complexes with matrix metalloproteases (MMPs) and inactivate them irreversibly by ...

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041763.1 Reference Mmul_10 Primary Assembly

      Range
      18645380..18703187 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5PXZ9.1 GenPept UniProtKB/Swiss-Prot:Q5PXZ9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.