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    GRK4 G protein-coupled receptor kinase 4 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 720047, updated on 17-Aug-2024

    Summary

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    Official Symbol
    GRK4provided by VGNC
    Official Full Name
    G protein-coupled receptor kinase 4provided by VGNC
    Primary source
    VGNC:VGNC:73266
    See related
    Ensembl:ENSMMUG00000008392
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See GRK4 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 5 NC_041758.1 (3077635..3154707)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 5 NC_027897.1 (3236459..3313436)

    Chromosome 5 - NC_041758.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC114678225 Neighboring gene major facilitator superfamily domain containing 10 Neighboring gene NOP14 nucleolar protein Neighboring gene U6 spliceosomal RNA Neighboring gene U7 small nuclear RNA Neighboring gene huntingtin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables G protein-coupled receptor kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    G protein-coupled receptor kinase 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041758.1 Reference Mmul_10 Primary Assembly

      Range
      3077635..3154707
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028848255.1 → XP_028704088.1  G protein-coupled receptor kinase 4 isoform X6

      UniProtKB/TrEMBL
      F6VR70
      Conserved Domains (2) summary
      cd05631
      Location:186 → 470
      STKc_GRK4; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4
      cl02565
      Location:52 → 184
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    2. XM_028848261.1 → XP_028704094.1  G protein-coupled receptor kinase 4 isoform X11

      Conserved Domains (2) summary
      cd05631
      Location:154 → 438
      STKc_GRK4; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4
      cl02565
      Location:20 → 152
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    3. XM_028848256.1 → XP_028704089.1  G protein-coupled receptor kinase 4 isoform X6

      UniProtKB/TrEMBL
      F6VR70
      Related
      ENSMMUP00000011004.4, ENSMMUT00000011734.4
      Conserved Domains (2) summary
      cd05631
      Location:186 → 470
      STKc_GRK4; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4
      cl02565
      Location:52 → 184
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    4. XM_028848271.1 → XP_028704104.1  G protein-coupled receptor kinase 4 isoform X19

      Conserved Domains (1) summary
      cl21453
      Location:1 → 259
      PKc_like; Protein Kinases, catalytic domain

    5. XM_028848270.1 → XP_028704103.1  G protein-coupled receptor kinase 4 isoform X19

      Conserved Domains (1) summary
      cl21453
      Location:1 → 259
      PKc_like; Protein Kinases, catalytic domain

    6. XM_028848267.1 → XP_028704100.1  G protein-coupled receptor kinase 4 isoform X18

      Conserved Domains (1) summary
      cl21453
      Location:5 → 276
      PKc_like; Protein Kinases, catalytic domain

    7. XM_028848266.1 → XP_028704099.1  G protein-coupled receptor kinase 4 isoform X17

      Conserved Domains (2) summary
      cl02565
      Location:85 → 217
      RGS; Regulator of G protein signaling (RGS) domain superfamily
      cl21453
      Location:217 → 383
      PKc_like; Protein Kinases, catalytic domain

    8. XM_028848265.1 → XP_028704098.1  G protein-coupled receptor kinase 4 isoform X16

      Conserved Domains (2) summary
      cl02565
      Location:85 → 217
      RGS; Regulator of G protein signaling (RGS) domain superfamily
      cl21453
      Location:219 → 464
      PKc_like; Protein Kinases, catalytic domain

    9. XM_028848250.1 → XP_028704083.1  G protein-coupled receptor kinase 4 isoform X1

      Conserved Domains (2) summary
      cd05631
      Location:219 → 503
      STKc_GRK4; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4
      cl02565
      Location:85 → 217
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    10. XM_028848258.1 → XP_028704091.1  G protein-coupled receptor kinase 4 isoform X8

      Conserved Domains (2) summary
      cd05631
      Location:219 → 502
      STKc_GRK4; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4
      cl02565
      Location:85 → 217
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    11. XM_028848264.1 → XP_028704097.1  G protein-coupled receptor kinase 4 isoform X14

      Conserved Domains (2) summary
      cd05631
      Location:219 → 502
      STKc_GRK4; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4
      cl02565
      Location:85 → 217
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    12. XM_028848257.1 → XP_028704090.1  G protein-coupled receptor kinase 4 isoform X7

      Conserved Domains (2) summary
      cd05631
      Location:219 → 503
      STKc_GRK4; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4
      cl02565
      Location:85 → 217
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    13. XM_028848252.1 → XP_028704085.1  G protein-coupled receptor kinase 4 isoform X3

      Conserved Domains (2) summary
      cd05631
      Location:193 → 477
      STKc_GRK4; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4
      cl02565
      Location:85 → 191
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    14. XM_028848259.1 → XP_028704092.1  G protein-coupled receptor kinase 4 isoform X9

      Conserved Domains (2) summary
      cd05631
      Location:219 → 503
      STKc_GRK4; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4
      cl02565
      Location:85 → 217
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    15. XM_028848262.1 → XP_028704095.1  G protein-coupled receptor kinase 4 isoform X12

      Conserved Domains (2) summary
      cd05631
      Location:219 → 503
      STKc_GRK4; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4
      cl02565
      Location:85 → 217
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    16. XM_028848251.1 → XP_028704084.1  G protein-coupled receptor kinase 4 isoform X2

      Conserved Domains (2) summary
      cd05631
      Location:219 → 503
      STKc_GRK4; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4
      cl02565
      Location:85 → 217
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    17. XM_028848263.1 → XP_028704096.1  G protein-coupled receptor kinase 4 isoform X13

      Conserved Domains (2) summary
      cd05631
      Location:219 → 502
      STKc_GRK4; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4
      cl02565
      Location:85 → 217
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    18. XM_028848254.1 → XP_028704087.1  G protein-coupled receptor kinase 4 isoform X5

      Conserved Domains (2) summary
      cl02565
      Location:85 → 217
      RGS; Regulator of G protein signaling (RGS) domain superfamily
      cl21453
      Location:219 → 473
      PKc_like; Protein Kinases, catalytic domain

    19. XM_028848260.1 → XP_028704093.1  G protein-coupled receptor kinase 4 isoform X10

      Conserved Domains (2) summary
      cl02565
      Location:85 → 217
      RGS; Regulator of G protein signaling (RGS) domain superfamily
      cl21453
      Location:219 → 443
      PKc_like; Protein Kinases, catalytic domain

    20. XM_028848249.1 → XP_028704082.1  G protein-coupled receptor kinase 4 isoform X1

      Conserved Domains (2) summary
      cd05631
      Location:219 → 503
      STKc_GRK4; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4
      cl02565
      Location:85 → 217
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    21. XM_015137887.2 → XP_014993373.1  G protein-coupled receptor kinase 4 isoform X15

      Conserved Domains (3) summary
      smart00220
      Location:175 → 350
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl02565
      Location:85 → 212
      RGS; Regulator of G protein signaling (RGS) domain superfamily
      cl21453
      Location:212 → 371
      PKc_like; Protein Kinases, catalytic domain

    22. XM_028848272.1 → XP_028704105.1  G protein-coupled receptor kinase 4 isoform X19

      Conserved Domains (1) summary
      cl21453
      Location:1 → 259
      PKc_like; Protein Kinases, catalytic domain

    23. XM_028848253.1 → XP_028704086.1  G protein-coupled receptor kinase 4 isoform X4

      UniProtKB/TrEMBL
      F6VR51
      Related
      ENSMMUP00000011005.4, ENSMMUT00000011735.4
      Conserved Domains (2) summary
      cd05631
      Location:191 → 475
      STKc_GRK4; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4
      cl02565
      Location:89 → 189
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    24. XM_028848269.1 → XP_028704102.1  G protein-coupled receptor kinase 4 isoform X19

      Conserved Domains (1) summary
      cl21453
      Location:1 → 259
      PKc_like; Protein Kinases, catalytic domain

    25. XM_028848268.1 → XP_028704101.1  G protein-coupled receptor kinase 4 isoform X18

      Conserved Domains (1) summary
      cl21453
      Location:5 → 276
      PKc_like; Protein Kinases, catalytic domain

    26. XM_015137895.2 → XP_014993381.1  G protein-coupled receptor kinase 4 isoform X19

      Conserved Domains (1) summary
      cl21453
      Location:1 → 259
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_003729512.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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