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    ACLY ATP citrate lyase [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 708501, updated on 17-Aug-2024

    Summary

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    Official Symbol
    ACLYprovided by VGNC
    Official Full Name
    ATP citrate lyaseprovided by VGNC
    Primary source
    VGNC:VGNC:99112
    Locus tag
    EGK_08718
    See related
    Ensembl:ENSMMUG00000018931
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See ACLY in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 16 NC_041769.1 (52984909..53048737, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 16 NC_027908.1 (47705333..47770326, complement)

    Chromosome 16 - NC_041769.1Genomic Context describing neighboring genes Neighboring gene kelch like family member 10 Neighboring gene kelch like family member 11 Neighboring gene uncharacterized LOC114673154 Neighboring gene outer dynein arm docking complex subunit 4 Neighboring gene 2',3'-cyclic nucleotide 3' phosphodiesterase Neighboring gene DnaJ heat shock protein family (Hsp40) member C7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP citrate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in acetyl-CoA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in citrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ATP-citrate synthase
    XP_014975158.1
    XP_014975159.1
    XP_014975160.1
    XP_014975161.1
    XP_014975162.1
    XP_014975163.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041769.1 Reference Mmul_10 Primary Assembly

      Range
      52984909..53048737 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015119676.2 → XP_014975162.1  ATP-citrate synthase isoform X3

      UniProtKB/TrEMBL
      H9FUT3, I0FI00
      Conserved Domains (7) summary
      cd06100
      Location:856 → 1093
      CCL_ACL-C; Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA). ...
      PLN02235
      Location:1 → 419
      PLN02235; ATP citrate (pro-S)-lyase
      PLN02522
      Location:491 → 1094
      PLN02522; ATP citrate (pro-S)-lyase
      smart00881
      Location:492 → 601
      CoA_binding; CoA binding domain
      pfam16114
      Location:247 → 421
      Citrate_bind; ATP citrate lyase citrate-binding
      cl17255
      Location:6 → 207
      ATP-grasp_4; ATP-grasp domain
      cl22543
      Location:660 → 785
      Ligase_CoA; CoA-ligase

    2. XM_015119675.2 → XP_014975161.1  ATP-citrate synthase isoform X3

      UniProtKB/TrEMBL
      H9FUT3, I0FI00
      Conserved Domains (7) summary
      cd06100
      Location:856 → 1093
      CCL_ACL-C; Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA). ...
      PLN02235
      Location:1 → 419
      PLN02235; ATP citrate (pro-S)-lyase
      PLN02522
      Location:491 → 1094
      PLN02522; ATP citrate (pro-S)-lyase
      smart00881
      Location:492 → 601
      CoA_binding; CoA binding domain
      pfam16114
      Location:247 → 421
      Citrate_bind; ATP citrate lyase citrate-binding
      cl17255
      Location:6 → 207
      ATP-grasp_4; ATP-grasp domain
      cl22543
      Location:660 → 785
      Ligase_CoA; CoA-ligase

    3. XM_015119674.2 → XP_014975160.1  ATP-citrate synthase isoform X3

      UniProtKB/TrEMBL
      H9FUT3, I0FI00
      Related
      ENSMMUP00000051015.2, ENSMMUT00000065903.2
      Conserved Domains (7) summary
      cd06100
      Location:856 → 1093
      CCL_ACL-C; Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA). ...
      PLN02235
      Location:1 → 419
      PLN02235; ATP citrate (pro-S)-lyase
      PLN02522
      Location:491 → 1094
      PLN02522; ATP citrate (pro-S)-lyase
      smart00881
      Location:492 → 601
      CoA_binding; CoA binding domain
      pfam16114
      Location:247 → 421
      Citrate_bind; ATP citrate lyase citrate-binding
      cl17255
      Location:6 → 207
      ATP-grasp_4; ATP-grasp domain
      cl22543
      Location:660 → 785
      Ligase_CoA; CoA-ligase

    4. XM_015119672.2 → XP_014975158.1  ATP-citrate synthase isoform X1

      UniProtKB/TrEMBL
      A0A1D5QVG7, I0FI00
      Related
      ENSMMUP00000052047.1, ENSMMUT00000063246.2
      Conserved Domains (7) summary
      cd06100
      Location:910 → 1147
      CCL_ACL-C; Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA). ...
      PLN02235
      Location:55 → 473
      PLN02235; ATP citrate (pro-S)-lyase
      PLN02522
      Location:545 → 1148
      PLN02522; ATP citrate (pro-S)-lyase
      smart00881
      Location:546 → 655
      CoA_binding; CoA binding domain
      pfam16114
      Location:301 → 475
      Citrate_bind; ATP citrate lyase citrate-binding
      cl17255
      Location:60 → 261
      ATP-grasp_4; ATP-grasp domain
      cl22543
      Location:714 → 839
      Ligase_CoA; CoA-ligase

    5. XM_015119673.2 → XP_014975159.1  ATP-citrate synthase isoform X2

      UniProtKB/TrEMBL
      G7NIJ9, I0FI00
      Conserved Domains (7) summary
      cd06100
      Location:900 → 1137
      CCL_ACL-C; Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA). ...
      PLN02235
      Location:55 → 473
      PLN02235; ATP citrate (pro-S)-lyase
      PLN02522
      Location:535 → 1138
      PLN02522; ATP citrate (pro-S)-lyase
      smart00881
      Location:536 → 645
      CoA_binding; CoA binding domain
      pfam16114
      Location:301 → 475
      Citrate_bind; ATP citrate lyase citrate-binding
      cl17255
      Location:60 → 261
      ATP-grasp_4; ATP-grasp domain
      cl22543
      Location:704 → 829
      Ligase_CoA; CoA-ligase

    6. XM_015119677.2 → XP_014975163.1  ATP-citrate synthase isoform X4

      UniProtKB/TrEMBL
      H9FUT4, I0FI00
      Related
      ENSMMUP00000054686.1, ENSMMUT00000060356.2
      Conserved Domains (7) summary
      cd06100
      Location:846 → 1083
      CCL_ACL-C; Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA). ...
      PLN02235
      Location:1 → 419
      PLN02235; ATP citrate (pro-S)-lyase
      PLN02522
      Location:481 → 1084
      PLN02522; ATP citrate (pro-S)-lyase
      smart00881
      Location:482 → 591
      CoA_binding; CoA binding domain
      pfam16114
      Location:247 → 421
      Citrate_bind; ATP citrate lyase citrate-binding
      cl17255
      Location:6 → 207
      ATP-grasp_4; ATP-grasp domain
      cl22543
      Location:650 → 775
      Ligase_CoA; CoA-ligase
    Nucleotide Protein
    Heading Accession and Version

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