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    ARHGEF12 Rho guanine nucleotide exchange factor 12 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 712096, updated on 17-Aug-2024

    Summary

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    Official Symbol
    ARHGEF12provided by VGNC
    Official Full Name
    Rho guanine nucleotide exchange factor 12provided by VGNC
    Primary source
    VGNC:VGNC:99547
    See related
    Ensembl:ENSMMUG00000012254
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See ARHGEF12 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    45
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 14 NC_041767.1 (113406660..113555066)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 14 NC_027906.1 (113196972..113345816)

    Chromosome 14 - NC_041767.1Genomic Context describing neighboring genes Neighboring gene POU class 2 homeobox 3 Neighboring gene TLC domain containing 5 Neighboring gene glutamate ionotropic receptor kainate type subunit 4 Neighboring gene elongin-C pseudogene Neighboring gene tubulin folding cofactor E like Neighboring gene tectorin alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Form deprivation modulates retinal neurogenesis in primate experimental myopia. Tkatchenko AV, et al. Proc Natl Acad Sci U S A, 2006 Mar 21. PMID 16537371, Free PMC Article
    2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rho guanine nucleotide exchange factor 12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041767.1 Reference Mmul_10 Primary Assembly

      Range
      113406660..113555066
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015115967.2 → XP_014971453.1  rho guanine nucleotide exchange factor 12 isoform X4

      UniProtKB/TrEMBL
      F6UZH5, I2CT39
      Related
      ENSMMUP00000016088.4, ENSMMUT00000017178.4
      Conserved Domains (4) summary
      cd08754
      Location:330 → 551
      RGS_LARG; Regulator of G protein signaling (RGS) domain found in the leukemia-associated Rho guanine nucleotide exchange factor (RhoGEF) protein (LARG)
      cd00992
      Location:52 → 126
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13390
      Location:976 → 1113
      PH_LARG; Leukemia-associated Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00621
      Location:772 → 957
      RhoGEF; RhoGEF domain

    2. XM_015115966.2 → XP_014971452.1  rho guanine nucleotide exchange factor 12 isoform X2

      UniProtKB/TrEMBL
      A0A1D5R2Y9, I2CT39
      Related
      ENSMMUP00000054674.2, ENSMMUT00000060790.2
      Conserved Domains (4) summary
      cd08754
      Location:349 → 570
      RGS_LARG; Regulator of G protein signaling (RGS) domain found in the leukemia-associated Rho guanine nucleotide exchange factor (RhoGEF) protein (LARG)
      cd00992
      Location:71 → 145
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13390
      Location:995 → 1132
      PH_LARG; Leukemia-associated Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00621
      Location:791 → 976
      RhoGEF; RhoGEF domain

    3. XM_015115970.2 → XP_014971456.1  rho guanine nucleotide exchange factor 12 isoform X7

      UniProtKB/TrEMBL
      H9F7A3
      Conserved Domains (4) summary
      cd08754
      Location:246 → 467
      RGS_LARG; Regulator of G protein signaling (RGS) domain found in the leukemia-associated Rho guanine nucleotide exchange factor (RhoGEF) protein (LARG)
      cd00992
      Location:2 → 42
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13390
      Location:892 → 1029
      PH_LARG; Leukemia-associated Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00621
      Location:688 → 873
      RhoGEF; RhoGEF domain

    4. XM_028834080.1 → XP_028689913.1  rho guanine nucleotide exchange factor 12 isoform X6

      UniProtKB/TrEMBL
      A0A5F8ARW5, H9F7A3
      Conserved Domains (4) summary
      cd08754
      Location:287 → 508
      RGS_LARG; Regulator of G protein signaling (RGS) domain found in the leukemia-associated Rho guanine nucleotide exchange factor (RhoGEF) protein (LARG)
      smart00325
      Location:729 → 914
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:9 → 83
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13390
      Location:933 → 1070
      PH_LARG; Leukemia-associated Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain

    5. XM_015115969.2 → XP_014971455.1  rho guanine nucleotide exchange factor 12 isoform X6

      UniProtKB/TrEMBL
      A0A5F8ARW5, H9F7A3
      Related
      ENSMMUP00000080695.1, ENSMMUT00000101585.1
      Conserved Domains (4) summary
      cd08754
      Location:287 → 508
      RGS_LARG; Regulator of G protein signaling (RGS) domain found in the leukemia-associated Rho guanine nucleotide exchange factor (RhoGEF) protein (LARG)
      smart00325
      Location:729 → 914
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:9 → 83
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13390
      Location:933 → 1070
      PH_LARG; Leukemia-associated Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain

    6. XM_028834079.1 → XP_028689912.1  rho guanine nucleotide exchange factor 12 isoform X5

      UniProtKB/TrEMBL
      A0A1D5RKM0
      Conserved Domains (4) summary
      cd08754
      Location:313 → 534
      RGS_LARG; Regulator of G protein signaling (RGS) domain found in the leukemia-associated Rho guanine nucleotide exchange factor (RhoGEF) protein (LARG)
      smart00325
      Location:755 → 940
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:75 → 149
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13390
      Location:959 → 1096
      PH_LARG; Leukemia-associated Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain

    7. XM_028834077.1 → XP_028689910.1  rho guanine nucleotide exchange factor 12 isoform X1

      UniProtKB/TrEMBL
      H9F7A3
      Related
      ENSMMUP00000044671.2, ENSMMUT00000054597.2
      Conserved Domains (4) summary
      cd08754
      Location:353 → 574
      RGS_LARG; Regulator of G protein signaling (RGS) domain found in the leukemia-associated Rho guanine nucleotide exchange factor (RhoGEF) protein (LARG)
      smart00325
      Location:795 → 980
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:75 → 149
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13390
      Location:999 → 1136
      PH_LARG; Leukemia-associated Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain

    8. XM_028834078.1 → XP_028689911.1  rho guanine nucleotide exchange factor 12 isoform X3

      UniProtKB/TrEMBL
      H9F7A3
      Conserved Domains (4) summary
      cd08754
      Location:334 → 555
      RGS_LARG; Regulator of G protein signaling (RGS) domain found in the leukemia-associated Rho guanine nucleotide exchange factor (RhoGEF) protein (LARG)
      smart00325
      Location:776 → 961
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:56 → 130
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13390
      Location:980 → 1117
      PH_LARG; Leukemia-associated Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
    Nucleotide Protein
    Heading Accession and Version

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