U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    MECOM MDS1 and EVI1 complex locus [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 698603, updated on 17-Aug-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    MECOMprovided by VGNC
    Official Full Name
    MDS1 and EVI1 complex locusprovided by VGNC
    Primary source
    VGNC:VGNC:74635
    Locus tag
    EGK_11925
    See related
    Ensembl:ENSMMUG00000002242
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Also known as
    EVI1
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See MECOM in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 2 NC_041755.1 (74004015..74596983, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 2 NC_027894.1 (124177867..124774088)

    Chromosome 2 - NC_041755.1Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein SA-like Neighboring gene uncharacterized LOC721629 Neighboring gene uncharacterized LOC106997011 Neighboring gene U6 spliceosomal RNA Neighboring gene telomerase RNA component

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol, 2011 Oct 16. PMID 22002653
    2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables histone H3K9 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    MDS1 and EVI1 complex locus protein EVI1; histone-lysine N-methyltransferase MECOM
    Names
    ecotropic viral integration site 1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041755.1 Reference Mmul_10 Primary Assembly

      Range
      74004015..74596983 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015131662.2 → XP_014987148.2  histone-lysine N-methyltransferase MECOM isoform X10

      Conserved Domains (4) summary
      smart00317
      Location:80 → 196
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      COG5048
      Location:289 → 640
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:599 → 619
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:611 → 635
      zf-H2C2_2; Zinc-finger double domain

    2. XM_015131660.2 → XP_014987146.2  histone-lysine N-methyltransferase MECOM isoform X9

      Conserved Domains (5) summary
      smart00317
      Location:80 → 196
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      COG5048
      Location:289 → 641
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:600 → 620
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:598 → 620
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:612 → 636
      zf-H2C2_2; Zinc-finger double domain

    3. XM_015131655.2 → XP_014987141.2  histone-lysine N-methyltransferase MECOM isoform X3

      UniProtKB/TrEMBL
      F6VYV2
      Conserved Domains (6) summary
      PHA00733
      Location:846 → 965
      PHA00733; hypothetical protein
      smart00317
      Location:80 → 196
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      sd00017
      Location:915 → 935
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam15909
      Location:352 → 436
      zf-C2H2_8; C2H2-type zinc ribbon
      pfam00096
      Location:913 → 935
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:927 → 951
      zf-H2C2_2; Zinc-finger double domain

    4. XM_015131654.2 → XP_014987140.2  histone-lysine N-methyltransferase MECOM isoform X1

      UniProtKB/TrEMBL
      F6VYV2
      Conserved Domains (6) summary
      smart00317
      Location:80 → 196
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      sd00017
      Location:924 → 944
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13909
      Location:950 → 975
      zf-H2C2_5; C2H2-type zinc-finger domain
      pfam15909
      Location:352 → 436
      zf-C2H2_8; C2H2-type zinc ribbon
      pfam00096
      Location:922 → 944
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:936 → 960
      zf-H2C2_2; Zinc-finger double domain

    5. XM_015131659.2 → XP_014987145.2  histone-lysine N-methyltransferase MECOM isoform X6

      UniProtKB/TrEMBL
      F6VYV2
      Conserved Domains (5) summary
      sd00017
      Location:735 → 755
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13909
      Location:761 → 786
      zf-H2C2_5; C2H2-type zinc-finger domain
      pfam15909
      Location:163 → 247
      zf-C2H2_8; C2H2-type zinc ribbon
      pfam00096
      Location:733 → 755
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:747 → 771
      zf-H2C2_2; Zinc-finger double domain

    6. XM_015131657.2 → XP_014987143.2  histone-lysine N-methyltransferase MECOM isoform X5

      UniProtKB/TrEMBL
      F6VYV2
      Conserved Domains (5) summary
      sd00017
      Location:736 → 756
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13909
      Location:762 → 787
      zf-H2C2_5; C2H2-type zinc-finger domain
      pfam15909
      Location:164 → 248
      zf-C2H2_8; C2H2-type zinc ribbon
      pfam00096
      Location:734 → 756
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:748 → 772
      zf-H2C2_2; Zinc-finger double domain

    7. XM_015131658.2 → XP_014987144.2  histone-lysine N-methyltransferase MECOM isoform X5

      UniProtKB/TrEMBL
      F6VYV2
      Related
      ENSMMUP00000002996.4, ENSMMUT00000003175.4
      Conserved Domains (5) summary
      sd00017
      Location:736 → 756
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13909
      Location:762 → 787
      zf-H2C2_5; C2H2-type zinc-finger domain
      pfam15909
      Location:164 → 248
      zf-C2H2_8; C2H2-type zinc ribbon
      pfam00096
      Location:734 → 756
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:748 → 772
      zf-H2C2_2; Zinc-finger double domain

    8. XM_001093583.4 → XP_001093583.3  histone-lysine N-methyltransferase MECOM isoform X2

      UniProtKB/TrEMBL
      F6VYV2
      Conserved Domains (6) summary
      smart00317
      Location:80 → 196
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      sd00017
      Location:923 → 943
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13909
      Location:949 → 974
      zf-H2C2_5; C2H2-type zinc-finger domain
      pfam15909
      Location:351 → 435
      zf-C2H2_8; C2H2-type zinc ribbon
      pfam00096
      Location:921 → 943
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:935 → 959
      zf-H2C2_2; Zinc-finger double domain

    9. XM_015131663.2 → XP_014987149.2  histone-lysine N-methyltransferase MECOM isoform X11

      Conserved Domains (4) summary
      smart00317
      Location:80 → 196
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      COG5048
      Location:289 → 631
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:590 → 610
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:602 → 626
      zf-H2C2_2; Zinc-finger double domain

    10. XM_015131656.2 → XP_014987142.2  histone-lysine N-methyltransferase MECOM isoform X4

      UniProtKB/TrEMBL
      F6VYV2
      Conserved Domains (6) summary
      PHA00733
      Location:845 → 964
      PHA00733; hypothetical protein
      smart00317
      Location:80 → 196
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      sd00017
      Location:914 → 934
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam15909
      Location:351 → 435
      zf-C2H2_8; C2H2-type zinc ribbon
      pfam00096
      Location:912 → 934
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:926 → 950
      zf-H2C2_2; Zinc-finger double domain

    11. XM_002802928.3 → XP_002802974.2  histone-lysine N-methyltransferase MECOM isoform X8

      UniProtKB/TrEMBL
      F6VYV2
      Conserved Domains (5) summary
      PHA00733
      Location:657 → 776
      PHA00733; hypothetical protein
      sd00017
      Location:726 → 746
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam15909
      Location:163 → 247
      zf-C2H2_8; C2H2-type zinc ribbon
      pfam00096
      Location:724 → 746
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:738 → 762
      zf-H2C2_2; Zinc-finger double domain

    12. XM_028843836.1 → XP_028699669.1  histone-lysine N-methyltransferase MECOM isoform X12

      Conserved Domains (5) summary
      PHA00733
      Location:333 → 452
      PHA00733; hypothetical protein
      COG5048
      Location:101 → 443
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:402 → 422
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:400 → 422
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:414 → 438
      zf-H2C2_2; Zinc-finger double domain

    13. XM_028843835.1 → XP_028699668.1  histone-lysine N-methyltransferase MECOM isoform X7

      UniProtKB/TrEMBL
      A0A1D5R6D6, F6VYV2
      Related
      ENSMMUP00000055874.2, ENSMMUT00000064913.2
      Conserved Domains (5) summary
      PHA00733
      Location:658 → 777
      PHA00733; hypothetical protein
      sd00017
      Location:727 → 747
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam15909
      Location:164 → 248
      zf-C2H2_8; C2H2-type zinc ribbon
      pfam00096
      Location:725 → 747
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:739 → 763
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.