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    TRIO trio Rho guanine nucleotide exchange factor [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 717492, updated on 17-Aug-2024

    Summary

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    Official Symbol
    TRIOprovided by VGNC
    Official Full Name
    trio Rho guanine nucleotide exchange factorprovided by VGNC
    Primary source
    VGNC:VGNC:84509
    See related
    Ensembl:ENSMMUG00000015489
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See TRIO in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    59
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 6 NC_041759.1 (14382238..14755552)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 6 NC_027898.1 (14542289..14908100)

    Chromosome 6 - NC_041759.1Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L29 pseudogene Neighboring gene dynein axonemal heavy chain 5 Neighboring gene uncharacterized LOC114678668 Neighboring gene OTU deubiquitinase with linear linkage specificity like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    triple functional domain protein
    Names
    triple functional domain (PTPRF interacting)
    XP_014995235.2
    XP_014995236.2
    XP_028705179.1
    XP_028705180.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041759.1 Reference Mmul_10 Primary Assembly

      Range
      14382238..14755552
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015139750.2 → XP_014995236.2  triple functional domain protein isoform X1

      UniProtKB/TrEMBL
      F6SBV8
      Related
      ENSMMUP00000020323.4, ENSMMUT00000021726.4
      Conserved Domains (12) summary
      smart00150
      Location:1143 → 1243
      SPEC; Spectrin repeats
      cd11852
      Location:1659 → 1718
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2551 → 2609
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:69 → 204
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      PHA03247
      Location:2331 → 2519
      PHA03247; large tegument protein UL36; Provisional
      cd00160
      Location:1970 → 2143
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:567 → 783
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:1472 → 1594
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2148 → 2286
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14113
      Location:2784 → 3046
      STKc_Trio_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Triple functional domain protein
      pfam16609
      Location:1716 → 1963
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      pfam07679
      Location:2681 → 2772
      I-set; Immunoglobulin I-set domain

    2. XM_028849347.1 → XP_028705180.1  triple functional domain protein isoform X4

      UniProtKB/TrEMBL
      H9FJM3
      Conserved Domains (7) summary
      smart00150
      Location:1143 → 1243
      SPEC; Spectrin repeats
      cd11852
      Location:1659 → 1718
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:69 → 204
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:1295 → 1465
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:567 → 783
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:1472 → 1594
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      pfam16609
      Location:1716 → 1889
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region

    3. XM_015139749.2 → XP_014995235.2  triple functional domain protein isoform X2

      Conserved Domains (12) summary
      smart00150
      Location:1143 → 1243
      SPEC; Spectrin repeats
      cd11852
      Location:1659 → 1718
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2551 → 2609
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:69 → 204
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      PHA03247
      Location:2331 → 2519
      PHA03247; large tegument protein UL36; Provisional
      cd00160
      Location:1970 → 2143
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:567 → 783
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:1472 → 1594
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2148 → 2286
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14113
      Location:2780 → 3042
      STKc_Trio_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Triple functional domain protein
      pfam16609
      Location:1716 → 1963
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      pfam07679
      Location:2677 → 2768
      I-set; Immunoglobulin I-set domain

    4. XM_028849346.1 → XP_028705179.1  triple functional domain protein isoform X3

      Conserved Domains (12) summary
      smart00150
      Location:1080 → 1180
      SPEC; Spectrin repeats
      cd11852
      Location:1596 → 1655
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd11853
      Location:2488 → 2546
      SH3_Kalirin_2; Second Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:11 → 141
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      PHA03247
      Location:2268 → 2456
      PHA03247; large tegument protein UL36; Provisional
      cd00160
      Location:1907 → 2080
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:504 → 720
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:1409 → 1531
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:2085 → 2223
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      cd14113
      Location:2721 → 2983
      STKc_Trio_C; C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Triple functional domain protein
      pfam16609
      Location:1653 → 1900
      SH3-RhoG_link; SH3-RhoGEF linking unstructured region
      pfam07679
      Location:2618 → 2709
      I-set; Immunoglobulin I-set domain
    Nucleotide Protein
    Heading Accession and Version

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