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    RBBP8 RB binding protein 8, endonuclease [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 677718, updated on 17-Aug-2024

    Summary

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    Official Symbol
    RBBP8provided by VGNC
    Official Full Name
    RB binding protein 8, endonucleaseprovided by VGNC
    Primary source
    VGNC:VGNC:104242
    See related
    Ensembl:ENSMMUG00000012715
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See RBBP8 in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 18 NC_041771.1 (59391448..59506039, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 18 NC_027910.1 (11381267..11502785)

    Chromosome 18 - NC_041771.1Genomic Context describing neighboring genes Neighboring gene Cdk5 and Abl enzyme substrate 1 Neighboring gene uncharacterized LOC114673732 Neighboring gene uncharacterized LOC114673731 Neighboring gene uncharacterized LOC106994445 Neighboring gene ubiquitin-conjugating enzyme E2 C-like Neighboring gene small nucleolar RNA U13 Neighboring gene uncharacterized LOC106994444 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ancient and recent adaptive evolution of primate non-homologous end joining genes. Demogines A, et al. PLoS Genet, 2010 Oct 21. PMID 20975951, Free PMC Article
    2. Form deprivation modulates retinal neurogenesis in primate experimental myopia. Tkatchenko AV, et al. Proc Natl Acad Sci U S A, 2006 Mar 21. PMID 16537371, Free PMC Article
    3. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables Y-form DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables damaged DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables double-strand/single-strand DNA junction binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables double-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables flap-structured DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables single-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA double-strand break processing involved in repair via single-strand annealing IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in double-strand break repair via homologous recombination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in site of double-strand break IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA endonuclease RBBP8
    Names
    retinoblastoma binding protein 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001258203.1 → NP_001245132.1  DNA endonuclease RBBP8

      See identical proteins and their annotated locations for NP_001245132.1

      Status: PROVISIONAL

      Source sequence(s)
      JU476649
      UniProtKB/TrEMBL
      E5FGG7, H9ZBY7
      Related
      ENSMMUP00000048570.1, ENSMMUT00000074216.2
      Conserved Domains (2) summary
      pfam08573
      Location:797 → 857
      SAE2; DNA repair protein endonuclease SAE2/CtIP C-terminus
      pfam10482
      Location:20 → 138
      CtIP_N; Tumour-suppressor protein CtIP N-terminal domain

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041771.1 Reference Mmul_10 Primary Assembly

      Range
      59391448..59506039 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028837673.1 → XP_028693506.1  DNA endonuclease RBBP8 isoform X1

      UniProtKB/TrEMBL
      E5FGG7, F7DF28
      Conserved Domains (2) summary
      pfam08573
      Location:798 → 858
      SAE2; DNA repair protein endonuclease SAE2/CtIP C-terminus
      pfam10482
      Location:20 → 138
      CtIP_N; tumor-suppressor protein CtIP N-terminal domain

    2. XM_028837675.1 → XP_028693508.1  DNA endonuclease RBBP8 isoform X2

      UniProtKB/TrEMBL
      E5FGG7
      Conserved Domains (1) summary
      pfam10482
      Location:20 → 138
      CtIP_N; tumor-suppressor protein CtIP N-terminal domain

    3. XM_028837674.1 → XP_028693507.1  DNA endonuclease RBBP8 isoform X1

      UniProtKB/TrEMBL
      E5FGG7, F7DF28
      Related
      ENSMMUP00000016693.3, ENSMMUT00000017827.4
      Conserved Domains (2) summary
      pfam08573
      Location:798 → 858
      SAE2; DNA repair protein endonuclease SAE2/CtIP C-terminus
      pfam10482
      Location:20 → 138
      CtIP_N; tumor-suppressor protein CtIP N-terminal domain

    4. XM_028837676.1 → XP_028693509.1  DNA endonuclease RBBP8 isoform X3

      UniProtKB/TrEMBL
      E5FGG7
      Conserved Domains (2) summary
      pfam10482
      Location:1 → 40
      CtIP_N; tumor-suppressor protein CtIP N-terminal domain
      pfam08573
      Location:700 → 760
      SAE2; DNA repair protein endonuclease SAE2/CtIP C-terminus
    Nucleotide Protein
    Heading Accession and Version

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