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    NCK1 NCK adaptor protein 1 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 716807, updated on 17-Aug-2024

    Summary

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    Official Symbol
    NCK1provided by VGNC
    Official Full Name
    NCK adaptor protein 1provided by VGNC
    Primary source
    VGNC:VGNC:110350
    Locus tag
    EGK_12077
    See related
    Ensembl:ENSMMUG00000055871
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See NCK1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 2 NC_041755.1 (39034812..39129587)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 2 NC_027894.1 (165047080..165141734, complement)

    Chromosome 2 - NC_041755.1Genomic Context describing neighboring genes Neighboring gene STAG1 cohesin complex component Neighboring gene 40S ribosomal protein S15a pseudogene Neighboring gene sulfotransferase 1 family member D1-like Neighboring gene U6 spliceosomal RNA Neighboring gene solute carrier family 35 member G2 Neighboring gene RAD51-associated protein 1 pseudogene Neighboring gene uncharacterized LOC106997107 Neighboring gene interleukin 20 receptor subunit beta Neighboring gene uncharacterized LOC114676130

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol, 2011 Oct 16. PMID 22002653
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ephrin receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of PERK-mediated unfolded protein response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of translation in response to endoplasmic reticulum stress IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    SH2/SH3 adapter protein NCK1; cytoplasmic protein NCK1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001257480.1 → NP_001244409.1  SH2/SH3 adapter protein NCK1

      See identical proteins and their annotated locations for NP_001244409.1

      Status: PROVISIONAL

      Source sequence(s)
      JU320326
      UniProtKB/TrEMBL
      A0A8J8XHZ7, F7E0A3, G7MJP9
      Related
      ENSMMUP00000064713.1, ENSMMUT00000097602.1
      Conserved Domains (4) summary
      cd10408
      Location:280 → 376
      SH2_Nck1; Src homology 2 (SH2) domain found in Nck
      cd11900
      Location:3 → 61
      SH3_Nck1_1; First Src Homology 3 domain of Nck1 adaptor protein
      cd11901
      Location:108 → 162
      SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
      cd11904
      Location:193 → 249
      SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041755.1 Reference Mmul_10 Primary Assembly

      Range
      39034812..39129587
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015132050.2 → XP_014987536.1  cytoplasmic protein NCK1 isoform X1

      UniProtKB/TrEMBL
      A0A8J8XHZ7, F7E0A3, G7MJP9
      Conserved Domains (4) summary
      cd10408
      Location:280 → 376
      SH2_Nck1; Src homology 2 (SH2) domain found in Nck
      cd11900
      Location:3 → 61
      SH3_Nck1_1; First Src Homology 3 domain of Nck1 adaptor protein
      cd11901
      Location:108 → 162
      SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
      cd11904
      Location:193 → 249
      SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein

    2. XM_028843422.1 → XP_028699255.1  cytoplasmic protein NCK1 isoform X1

      UniProtKB/TrEMBL
      A0A8J8XHZ7, F7E0A3, G7MJP9
      Related
      ENSMMUP00000078463.1, ENSMMUT00000108140.1
      Conserved Domains (4) summary
      cd10408
      Location:280 → 376
      SH2_Nck1; Src homology 2 (SH2) domain found in Nck
      cd11900
      Location:3 → 61
      SH3_Nck1_1; First Src Homology 3 domain of Nck1 adaptor protein
      cd11901
      Location:108 → 162
      SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
      cd11904
      Location:193 → 249
      SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein

    3. XM_028843423.1 → XP_028699256.1  cytoplasmic protein NCK1 isoform X1

      UniProtKB/TrEMBL
      A0A8J8XHZ7, F7E0A3, G7MJP9
      Conserved Domains (4) summary
      cd10408
      Location:280 → 376
      SH2_Nck1; Src homology 2 (SH2) domain found in Nck
      cd11900
      Location:3 → 61
      SH3_Nck1_1; First Src Homology 3 domain of Nck1 adaptor protein
      cd11901
      Location:108 → 162
      SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
      cd11904
      Location:193 → 249
      SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein

    4. XM_015132051.2 → XP_014987537.1  cytoplasmic protein NCK1 isoform X1

      UniProtKB/TrEMBL
      A0A8J8XHZ7, F7E0A3, G7MJP9
      Related
      ENSMMUP00000069934.1, ENSMMUT00000088671.1
      Conserved Domains (4) summary
      cd10408
      Location:280 → 376
      SH2_Nck1; Src homology 2 (SH2) domain found in Nck
      cd11900
      Location:3 → 61
      SH3_Nck1_1; First Src Homology 3 domain of Nck1 adaptor protein
      cd11901
      Location:108 → 162
      SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
      cd11904
      Location:193 → 249
      SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein

    5. XM_015132052.2 → XP_014987538.1  cytoplasmic protein NCK1 isoform X1

      UniProtKB/TrEMBL
      A0A8J8XHZ7, F7E0A3, G7MJP9
      Conserved Domains (4) summary
      cd10408
      Location:280 → 376
      SH2_Nck1; Src homology 2 (SH2) domain found in Nck
      cd11900
      Location:3 → 61
      SH3_Nck1_1; First Src Homology 3 domain of Nck1 adaptor protein
      cd11901
      Location:108 → 162
      SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
      cd11904
      Location:193 → 249
      SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein

    6. XM_028843424.1 → XP_028699257.1  cytoplasmic protein NCK1 isoform X1

      UniProtKB/TrEMBL
      A0A8J8XHZ7, F7E0A3, G7MJP9
      Conserved Domains (4) summary
      cd10408
      Location:280 → 376
      SH2_Nck1; Src homology 2 (SH2) domain found in Nck
      cd11900
      Location:3 → 61
      SH3_Nck1_1; First Src Homology 3 domain of Nck1 adaptor protein
      cd11901
      Location:108 → 162
      SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
      cd11904
      Location:193 → 249
      SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein

    7. XM_015132053.2 → XP_014987539.1  cytoplasmic protein NCK1 isoform X2

      UniProtKB/TrEMBL
      A0A5F8AH39
      Related
      ENSMMUP00000076721.1, ENSMMUT00000109091.1
      Conserved Domains (3) summary
      cd10408
      Location:216 → 312
      SH2_Nck1; Src homology 2 (SH2) domain found in Nck
      cd11901
      Location:44 → 98
      SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
      cd11904
      Location:129 → 185
      SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein
    Nucleotide Protein
    Heading Accession and Version

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