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    RGL2 ral guanine nucleotide dissociation stimulator like 2 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 718198, updated on 17-Aug-2024

    Summary

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    Official Symbol
    RGL2provided by VGNC
    Official Full Name
    ral guanine nucleotide dissociation stimulator like 2provided by VGNC
    Primary source
    VGNC:VGNC:76886
    See related
    Ensembl:ENSMMUG00000003872
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See RGL2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 4 NC_041757.1 (136205793..136215391)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 4 NC_027896.1 (34135082..34144802, complement)

    Chromosome 4 - NC_041757.1Genomic Context describing neighboring genes Neighboring gene death domain associated protein Neighboring gene zinc finger and BTB domain containing 22 Neighboring gene TAP binding protein Neighboring gene prefoldin subunit 6 Neighboring gene WD repeat domain 46 Neighboring gene beta-1,3-galactosyltransferase 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ral guanine nucleotide dissociation stimulator-like 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001194701.2 → NP_001181630.1  ral guanine nucleotide dissociation stimulator-like 2

      See identical proteins and their annotated locations for NP_001181630.1

      Status: PROVISIONAL

      Source sequence(s)
      QNVO02000341
      UniProtKB/TrEMBL
      F6TVC3, G7MRQ1, I0FTV6
      Related
      ENSMMUP00000033858.3, ENSMMUT00000040832.3
      Conserved Domains (3) summary
      cd00153
      Location:648 → 733
      RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
      smart00147
      Location:239 → 513
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:90 → 212
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041757.1 Reference Mmul_10 Primary Assembly

      Range
      136205793..136215391
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028846857.1 → XP_028702690.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X1

      UniProtKB/TrEMBL
      G7MRQ1
      Conserved Domains (3) summary
      smart00147
      Location:239 → 552
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:90 → 212
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd17211
      Location:687 → 772
      RA_RGL2; Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like 2) and similar proteins

    2. XM_028846858.1 → XP_028702691.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X2

      UniProtKB/TrEMBL
      G7MRQ1
      Conserved Domains (3) summary
      smart00147
      Location:157 → 470
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:8 → 130
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd17211
      Location:605 → 690
      RA_RGL2; Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like 2) and similar proteins

    3. XM_015136069.2 → XP_014991555.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X3

      UniProtKB/TrEMBL
      G7MRQ1
      Conserved Domains (3) summary
      cd00153
      Location:566 → 651
      RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
      smart00147
      Location:157 → 431
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:8 → 130
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

    4. XM_028846860.1 → XP_028702693.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X2

      UniProtKB/TrEMBL
      G7MRQ1
      Conserved Domains (3) summary
      smart00147
      Location:157 → 470
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:8 → 130
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd17211
      Location:605 → 690
      RA_RGL2; Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like 2) and similar proteins

    5. XM_028846859.1 → XP_028702692.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X2

      UniProtKB/TrEMBL
      G7MRQ1
      Conserved Domains (3) summary
      smart00147
      Location:157 → 470
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:8 → 130
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd17211
      Location:605 → 690
      RA_RGL2; Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like 2) and similar proteins
    Nucleotide Protein
    Heading Accession and Version

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