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    RTD1A demidefensin 2 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 574122, updated on 9-Nov-2023

    Summary

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    Gene symbol
    RTD1A
    Gene description
    demidefensin 2
    See related
    Ensembl:ENSMMUG00000054742
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Also known as
    RTD-3
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    Genomic context

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    See RTD1A in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 8 NC_041761.1 (7715023..7717554, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 8 NC_027900.1 (7143683..7146214, complement)

    Chromosome 8 - NC_041761.1Genomic Context describing neighboring genes Neighboring gene neutrophil defensin 4-like Neighboring gene demidefensin 3 Neighboring gene demidefensin 1 Neighboring gene defensin alpha 1B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rhesus theta-defensin prevents death in a mouse model of severe acute respiratory syndrome coronavirus pulmonary disease. Wohlford-Lenane CL, et al. J Virol, 2009 Nov. PMID 19710146, Free PMC Article
    2. Homodimeric theta-defensins from rhesus macaque leukocytes: isolation, synthesis, antimicrobial activities, and bacterial binding properties of the cyclic peptides. Tran D, et al. J Biol Chem, 2002 Feb 1. PMID 11675394
    3. Circular minidefensins and posttranslational generation of molecular diversity. Leonova L, et al. J Leukoc Biol, 2001 Sep. PMID 11527997
    4. A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated alpha-defensins. Tang YQ, et al. Science, 1999 Oct 15. PMID 10521339
    5. Molecular evolution of the primate α-/θ-defensin multigene family. Cheng DQ, et al. PLoS One, 2014. PMID 24819937, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This paper identifies three theta defensins in macaque.
      Title: Molecular evolution of the primate α-/θ-defensin multigene family.
    2. Data suggest that rhesus theta-defensin prevents death in a mouse model of severe acute respiratory syndrome coronavirus pulmonary disease, and that one possible mechanism of action for RTD-1 is immunomodulatory.
      Title: Rhesus theta-defensin prevents death in a mouse model of severe acute respiratory syndrome coronavirus pulmonary disease.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in antibacterial humoral response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cellular response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in defense response to Gram-negative bacterium IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in defense response to Gram-positive bacterium IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in disruption of plasma membrane integrity in another organism IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in innate immune response in mucosa IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rhesus theta defensin-1/3 subunit A
    Names
    RTD-1 subunit A
    theta defensin 1a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001032817.2 → NP_001027989.1  rhesus theta defensin-1/3 subunit A precursor

      See identical proteins and their annotated locations for NP_001027989.1

      Status: PROVISIONAL

      Source sequence(s)
      AF191100
      UniProtKB/Swiss-Prot
      P82270, Q9TU01
      UniProtKB/TrEMBL
      G7N0F5
      Related
      ENSMMUP00000061272.1, ENSMMUT00000104710.1
      Conserved Domains (1) summary
      pfam00879
      Location:1 → 52
      Defensin_propep; Defensin propeptide

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041761.1 Reference Mmul_10 Primary Assembly

      Range
      7715023..7717554 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P82270.1 GenPept UniProtKB/Swiss-Prot:P82270

    Gene LinkOut

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    Molecular Biology Databases
    Research Materials