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    NEDD4 NEDD4 E3 ubiquitin protein ligase [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 699550, updated on 17-Aug-2024

    Summary

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    Official Symbol
    NEDD4provided by VGNC
    Official Full Name
    NEDD4 E3 ubiquitin protein ligaseprovided by VGNC
    Primary source
    VGNC:VGNC:75302
    See related
    Ensembl:ENSMMUG00000008112
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See NEDD4 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 7 NC_041760.1 (32214341..32381330, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 7 NC_027899.1 (32289892..32456925, complement)

    Chromosome 7 - NC_041760.1Genomic Context describing neighboring genes Neighboring gene pygopus family PHD finger 1 Neighboring gene protogenin Neighboring gene POU domain, class 5, transcription factor 3-like Neighboring gene small nucleolar RNA U13 Neighboring gene uncharacterized LOC114679412 Neighboring gene regulatory factor X7 Neighboring gene hydroxyacyl-coenzyme A dehydrogenase, mitochondrial pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables sodium channel inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of sodium ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in neuromuscular junction development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in receptor catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in receptor internalization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of dendrite morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase NEDD4
    Names
    neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
    XP_001088005.4
    XP_014997786.2
    XP_014997787.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041760.1 Reference Mmul_10 Primary Assembly

      Range
      32214341..32381330 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015142301.2 → XP_014997787.1  E3 ubiquitin-protein ligase NEDD4 isoform X3

      UniProtKB/TrEMBL
      F7HIT1, H9FUU5
      Related
      ENSMMUP00000010623.3, ENSMMUT00000011335.4
      Conserved Domains (4) summary
      cd04033
      Location:20 → 151
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:474 → 506
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:567 → 896
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:350 → 379
      WW; WW domain

    2. XM_001088005.4 → XP_001088005.4  E3 ubiquitin-protein ligase NEDD4 isoform X1

      UniProtKB/TrEMBL
      A0A5F8A505, G7MXI5
      Related
      ENSMMUP00000073029.1, ENSMMUT00000106165.1
      Conserved Domains (5) summary
      smart00456
      Location:893 → 925
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:986 → 1315
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00201
      Location:843 → 873
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:769 → 798
      WW; WW domain
      cl14603
      Location:517 → 570
      C2; C2 domain

    3. XM_015142300.2 → XP_014997786.2  E3 ubiquitin-protein ligase NEDD4 isoform X2

      UniProtKB/TrEMBL
      F7GSC9, G7MXI5
      Related
      ENSMMUP00000033590.3, ENSMMUT00000040533.3
      Conserved Domains (5) summary
      smart00456
      Location:876 → 908
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:969 → 1298
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00201
      Location:826 → 856
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam00397
      Location:752 → 781
      WW; WW domain
      cl14603
      Location:513 → 553
      C2; C2 domain
    Nucleotide Protein
    Heading Accession and Version

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