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    NOX4 NADPH oxidase 4 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 705931, updated on 17-Aug-2024

    Summary

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    Official Symbol
    NOX4provided by VGNC
    Official Full Name
    NADPH oxidase 4provided by VGNC
    Primary source
    VGNC:VGNC:75376
    See related
    Ensembl:ENSMMUG00000011116
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See NOX4 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 14 NC_041767.1 (82455460..82626714, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 14 NC_027906.1 (81848162..82020154, complement)

    Chromosome 14 - NC_041767.1Genomic Context describing neighboring genes Neighboring gene glutamate metabotropic receptor 5 Neighboring gene uncharacterized LOC114672332 Neighboring gene chromobox protein homolog 3 pseudogene Neighboring gene tyrosinase Neighboring gene Putative N-acetylated-alpha-linked acidic dipeptidase Neighboring gene tripartite motif containing 77

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables superoxide-generating NAD(P)H oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in superoxide anion generation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NADPH oxidase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NADPH oxidase 4
    XP_001105331.1
    XP_001105410.1
    XP_002799783.2
    XP_014970877.1
    XP_014970878.1
    XP_028689732.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041767.1 Reference Mmul_10 Primary Assembly

      Range
      82455460..82626714 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001105331.4 → XP_001105331.1  NADPH oxidase 4 isoform X5

      UniProtKB/TrEMBL
      F6TZ83, F6WZN5
      Related
      ENSMMUP00000036800.1, ENSMMUT00000043814.3
      Conserved Domains (2) summary
      cd06186
      Location:311 → 537
      NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
      pfam01794
      Location:69 → 204
      Ferric_reduct; Ferric reductase like transmembrane component

    2. XM_015115391.2 → XP_014970877.1  NADPH oxidase 4 isoform X2

      UniProtKB/TrEMBL
      F6TZ83
      Conserved Domains (2) summary
      cd06186
      Location:311 → 576
      NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
      PLN02844
      Location:69 → 479
      PLN02844; oxidoreductase/ferric-chelate reductase

    3. XM_001105410.4 → XP_001105410.1  NADPH oxidase 4 isoform X1

      UniProtKB/TrEMBL
      A0A1D5RB90, F6TZ83
      Related
      ENSMMUP00000057581.2, ENSMMUT00000070865.2
      Conserved Domains (2) summary
      cd06186
      Location:311 → 577
      NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
      PLN02844
      Location:69 → 479
      PLN02844; oxidoreductase/ferric-chelate reductase

    4. XM_015115392.2 → XP_014970878.1  NADPH oxidase 4 isoform X6

      UniProtKB/TrEMBL
      F6TZ83
      Conserved Domains (2) summary
      cd06186
      Location:237 → 503
      NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
      pfam01794
      Location:4 → 130
      Ferric_reduct; Ferric reductase like transmembrane component

    5. XM_028833899.1 → XP_028689732.1  NADPH oxidase 4 isoform X3

      UniProtKB/TrEMBL
      F6TZ83
      Conserved Domains (2) summary
      cd06186
      Location:287 → 553
      NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
      PLN02844
      Location:45 → 455
      PLN02844; oxidoreductase/ferric-chelate reductase

    6. XM_002799737.3 → XP_002799783.2  NADPH oxidase 4 isoform X4

      UniProtKB/TrEMBL
      F6TZ83
      Conserved Domains (2) summary
      cd06186
      Location:286 → 552
      NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
      PLN02844
      Location:44 → 454
      PLN02844; oxidoreductase/ferric-chelate reductase
    Nucleotide Protein
    Heading Accession and Version

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