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    HMBS hydroxymethylbilane synthase [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 702943, updated on 17-Aug-2024

    Summary

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    Official Symbol
    HMBSprovided by VGNC
    Official Full Name
    hydroxymethylbilane synthaseprovided by VGNC
    Primary source
    VGNC:VGNC:73479
    Locus tag
    EGK_06976
    See related
    Ensembl:ENSMMUG00000014866
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See HMBS in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 14 NC_041767.1 (112152041..112160437)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 14 NC_027906.1 (111941411..111949830)

    Chromosome 14 - NC_041767.1Genomic Context describing neighboring genes Neighboring gene hypoxia up-regulated 1 Neighboring gene VPS11 core subunit of CORVET and HOPS complexes Neighboring gene H2A.X variant histone Neighboring gene dolichyl-phosphate N-acetylglucosaminephosphotransferase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol, 2011 Oct 16. PMID 22002653
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables hydroxymethylbilane synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in heme biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in peptidyl-pyrromethane cofactor linkage IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    porphobilinogen deaminase
    NP_001253589.1
    XP_014971374.1
    XP_014971375.1
    XP_028688434.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001266660.1 → NP_001253589.1  porphobilinogen deaminase

      See identical proteins and their annotated locations for NP_001253589.1

      Status: PROVISIONAL

      Source sequence(s)
      JU475372
      UniProtKB/TrEMBL
      A0A5K1V982, I0FM95
      Related
      ENSMMUP00000036653.3, ENSMMUT00000043660.3
      Conserved Domains (1) summary
      cd13645
      Location:20 → 299
      PBP2_HuPBGD_like; Human porphobilinogen deaminase possess type 2 periplasmic binding protein fold

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041767.1 Reference Mmul_10 Primary Assembly

      Range
      112152041..112160437
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015115888.2 → XP_014971374.1  porphobilinogen deaminase isoform X1

      UniProtKB/TrEMBL
      A0A1D5RA18, A0A5S6RBT8, A0A8J8Y8A1, F6U3X9, G7NCE4, H9FTQ6
      Related
      ENSMMUP00000019513.4, ENSMMUT00000020856.4
      Conserved Domains (1) summary
      cd13645
      Location:50 → 329
      PBP2_HuPBGD_like; Human porphobilinogen deaminase possess type 2 periplasmic binding protein fold

    2. XM_028832601.1 → XP_028688434.1  porphobilinogen deaminase isoform X3

      UniProtKB/TrEMBL
      I0FM95
      Related
      ENSMMUP00000057159.2, ENSMMUT00000056453.2
      Conserved Domains (1) summary
      cd13645
      Location:12 → 281
      PBP2_HuPBGD_like; Human porphobilinogen deaminase possess type 2 periplasmic binding protein fold

    3. XM_015115889.2 → XP_014971375.1  porphobilinogen deaminase isoform X2

      UniProtKB/TrEMBL
      F6Y293
      Conserved Domains (1) summary
      cd13645
      Location:3 → 282
      PBP2_HuPBGD_like; Human porphobilinogen deaminase possess type 2 periplasmic binding protein fold
    Nucleotide Protein
    Heading Accession and Version

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