PSEN1 presenilin 1 [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Official Symbol: PSEN1provided by VGNC
Official Full Name: presenilin 1provided by VGNC
Primary source: VGNC:VGNC:76435
See related: Ensembl:ENSMMUG00000010173
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	7	NC_041760.1 (135266009..135350251)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	7	NC_027899.1 (135507109..135589501)

Chromosome 7 - NC_041760.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

G35565 (e-PCR)
- UniSTS:25416

G38175 (e-PCR)
- UniSTS:73545

G38218 (e-PCR)
- UniSTS:5967

G35665 (e-PCR)
- UniSTS:38760

D14S1440 (e-PCR)
- UniSTS:153983

PSEN1 (e-PCR)
- UniSTS:480427

SHGC-36769 (e-PCR)
- UniSTS:18869

G38220 (e-PCR)
- UniSTS:9152

G38203 (e-PCR)
- UniSTS:67017

G38184 (e-PCR)
- UniSTS:65743

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables aspartic endopeptidase activity, intramembrane cleaving	IEA Inferred from Electronic Annotation more info	PubMed
enables beta-catenin binding	IEA Inferred from Electronic Annotation more info	PubMed
enables cadherin binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in Notch receptor processing	IEA Inferred from Electronic Annotation more info	PubMed
involved_in amyloid precursor protein catabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in amyloid-beta metabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in calcium ion transport	IEA Inferred from Electronic Annotation more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in membrane protein ectodomain proteolysis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein processing	IEA Inferred from Electronic Annotation more info	PubMed
involved_in smooth endoplasmic reticulum calcium ion homeostasis	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in Z disc	IEA Inferred from Electronic Annotation more info	PubMed
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in cell cortex	IEA Inferred from Electronic Annotation more info	PubMed
located_in cell surface	IEA Inferred from Electronic Annotation more info	PubMed
located_in ciliary rootlet	IEA Inferred from Electronic Annotation more info	PubMed
located_in dendritic shaft	IEA Inferred from Electronic Annotation more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info	PubMed
located_in growth cone	IEA Inferred from Electronic Annotation more info	PubMed
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in membrane raft	IEA Inferred from Electronic Annotation more info	PubMed
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in neuromuscular junction	IEA Inferred from Electronic Annotation more info	PubMed
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: presenilin-1

NP_001253409.1

EC 3.4.23.-

XP_014999523.1

EC 3.4.23.-

XP_028706046.1

EC 3.4.23.-

XP_028706047.1

EC 3.4.23.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.