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    DUOX1 dual oxidase 1 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 713126, updated on 17-Aug-2024

    Summary

    Official Symbol
    DUOX1provided by VGNC
    Official Full Name
    dual oxidase 1provided by VGNC
    Primary source
    VGNC:VGNC:72009
    See related
    Ensembl:ENSMMUG00000008752
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
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    Genomic context

    See DUOX1 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 7 NC_041760.1 (21550894..21587372)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 7 NC_027899.1 (21433457..21468600)

    Chromosome 7 - NC_041760.1Genomic Context describing neighboring genes Neighboring gene dual oxidase 2 Neighboring gene dual oxidase maturation factor 2 Neighboring gene dual oxidase maturation factor 1 Neighboring gene Src homology 2 domain containing F Neighboring gene transfer RNA histidin (anticodon GUG)

    Genomic regions, transcripts, and products

    General gene information

    Markers

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    enables peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    enables superoxide-generating NAD(P)H oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in defense response IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    involved_in superoxide anion generation IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of NADPH oxidase complex IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    PubMed 

    General protein information

    Preferred Names
    dual oxidase 1
    XP_014997627.2
    XP_028706704.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041760.1 Reference Mmul_10 Primary Assembly

      Range
      21550894..21587372
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028850871.1XP_028706704.1  dual oxidase 1 isoform X1

      UniProtKB/TrEMBL
      A0A5F7ZFY5, G7MX81
      Related
      ENSMMUP00000063530.1, ENSMMUT00000097561.1
      Conserved Domains (5) summary
      cd06186
      Location:12771456
      NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
      cd09820
      Location:32591
      dual_peroxidase_like; Dual oxidase and related animal heme peroxidases
      PLN02292
      Location:10891412
      PLN02292; ferric-chelate reductase
      COG5126
      Location:756920
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cd00051
      Location:820881
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    2. XM_015142141.2XP_014997627.2  dual oxidase 1 isoform X2

      UniProtKB/TrEMBL
      F7DQZ5, G7MX81
      Related
      ENSMMUP00000011470.4, ENSMMUT00000012229.4
      Conserved Domains (5) summary
      cd06186
      Location:12771551
      NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
      cd09820
      Location:32591
      dual_peroxidase_like; Dual oxidase and related animal heme peroxidases
      PLN02292
      Location:10891412
      PLN02292; ferric-chelate reductase
      COG5126
      Location:756920
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cd00051
      Location:820881
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...