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    VAV3 vav guanine nucleotide exchange factor 3 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 694685, updated on 17-Aug-2024

    Summary

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    Official Symbol
    VAV3provided by VGNC
    Official Full Name
    vav guanine nucleotide exchange factor 3provided by VGNC
    Primary source
    VGNC:VGNC:78759
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See VAV3 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 1 NC_041754.1 (116346097..116743570)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 1 NC_027893.1 (108452166..108850611, complement)

    Chromosome 1 - NC_041754.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 member 24 Neighboring gene uncharacterized LOC114678121 Neighboring gene uncharacterized LOC114671400 Neighboring gene netrin G1 Neighboring gene protein arginine methyltransferase 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    guanine nucleotide exchange factor VAV3
    Names
    vav 3 guanine nucleotide exchange factor
    vav 3 oncogene

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041754.1 Reference Mmul_10 Primary Assembly

      Range
      116346097..116743570
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001083337.4 → XP_001083337.1  guanine nucleotide exchange factor VAV3 isoform X2

      UniProtKB/TrEMBL
      F7H0I2
      Conserved Domains (8) summary
      cd10407
      Location:666 → 768
      SH2_Vav3; Src homology 2 (SH2) domain found in the Vav3 proteins
      cd11978
      Location:791 → 846
      SH3_VAV3_2; C-terminal (or second) Src homology 3 domain of VAV3 protein
      cd11981
      Location:596 → 657
      SH3_VAV3_1; First Src homology 3 domain of VAV3 protein
      cd00029
      Location:514 → 561
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00160
      Location:193 → 369
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01223
      Location:383 → 506
      PH_Vav; Vav pleckstrin homology (PH) domain
      pfam00169
      Location:407 → 502
      PH; PH domain
      pfam11971
      Location:18 → 103
      CAMSAP_CH; CAMSAP CH domain

    2. XM_002801681.3 → XP_002801727.1  guanine nucleotide exchange factor VAV3 isoform X1

      UniProtKB/TrEMBL
      F7BD31
      Conserved Domains (8) summary
      cd10407
      Location:666 → 768
      SH2_Vav3; Src homology 2 (SH2) domain found in the Vav3 proteins
      cd11978
      Location:819 → 874
      SH3_VAV3_2; C-terminal (or second) Src homology 3 domain of VAV3 protein
      cd11981
      Location:596 → 657
      SH3_VAV3_1; First Src homology 3 domain of VAV3 protein
      cd00029
      Location:514 → 561
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00160
      Location:193 → 369
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01223
      Location:383 → 506
      PH_Vav; Vav pleckstrin homology (PH) domain
      pfam00169
      Location:407 → 502
      PH; PH domain
      pfam11971
      Location:18 → 103
      CAMSAP_CH; CAMSAP CH domain
    Nucleotide Protein
    Heading Accession and Version

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