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    MAMU-DPA major histocompatibility complex, class II, DP alpha [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 717992, updated on 5-Mar-2024

    Summary

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    Gene symbol
    MAMU-DPA
    Gene description
    major histocompatibility complex, class II, DP alpha
    See related
    Ensembl:ENSMMUG00000019371
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Also known as
    Mamu-DPA1
    Orthologs
    human all
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    Genomic context

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    See MAMU-DPA in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 4 NC_041757.1 (136430783..136440626)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 4 NC_027896.1 (33909333..33919265, complement)

    Chromosome 4 - NC_041757.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC114677627 Neighboring gene uncharacterized LOC106997908 Neighboring gene major histocompatibility complex, class II, DP beta Neighboring gene elongation factor 1-alpha 1 pseudogene Neighboring gene major histocompatibility complex, class II, DO alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of Mamu-DPA1, Mamu-DQA1, and Mamu-DRA alleles in a cohort of Chinese rhesus macaques. Deng Q, et al. Immunogenetics, 2013 Dec. PMID 24042461
    2. The major histocompatibility complex class II alleles Mamu-DRB1*1003 and -DRB1*0306 are enriched in a cohort of simian immunodeficiency virus-infected rhesus macaque elite controllers. Giraldo-Vela JP, et al. J Virol, 2008 Jan. PMID 17989178, Free PMC Article
    3. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables MHC class II protein complex binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immunoglobulin production involved in immunoglobulin-mediated immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in peptide antigen assembly with MHC class II protein complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of T cell activation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MHC class II protein complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    major histocompatibility complex, class II, DP alpha
    Names
    MHC class II DPA
    MHC class II antigen
    Mhc DP-alpha
    major histocompatibility complex class II
    mamu-0008DPA01
    mamu-89002DPA01

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001048247.1 → NP_001041712.1  major histocompatibility complex, class II, DP alpha precursor

      See identical proteins and their annotated locations for NP_001041712.1

      Status: PROVISIONAL

      Source sequence(s)
      AB219099
      UniProtKB/TrEMBL
      A2TJ58, Q18PF3
      Conserved Domains (3) summary
      cd05767
      Location:117 → 210
      IgC_MHC_II_alpha; Class II major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      pfam00993
      Location:36 → 113
      MHC_II_alpha; Class II histocompatibility antigen, alpha domain
      pfam16196
      Location:208 → 259
      C1-set_C; C1-set C-terminal domain

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041757.1 Reference Mmul_10 Primary Assembly

      Range
      136430783..136440626
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015136066.2 → XP_014991552.2  major histocompatibility complex, class II, DP alpha

      UniProtKB/TrEMBL
      A3F8Y2, B5M480, S6DFB2
      Related
      ENSMMUP00000025452.3, ENSMMUT00000027208.4
      Conserved Domains (2) summary
      cd05767
      Location:117 → 210
      IgC_MHC_II_alpha; Class II major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      pfam00993
      Location:35 → 112
      MHC_II_alpha; Class II histocompatibility antigen, alpha domain
    Nucleotide Protein
    Heading Accession and Version

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