ARHGEF2 Rho/Rac guanine nucleotide exchange factor 2 [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Official Symbol: ARHGEF2provided by VGNC
Official Full Name: Rho/Rac guanine nucleotide exchange factor 2provided by VGNC
Primary source: VGNC:VGNC:70013
See related: Ensembl:ENSMMUG00000005092
Gene type: protein coding
RefSeq status: MODEL
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	1	NC_041754.1 (94972930..95042218)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	1	NC_027893.1 (130525945..130594369, complement)

Chromosome 1 - NC_041754.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

ARHGEF2_7937 (e-PCR)
- UniSTS:471347

G15881 (e-PCR)
- UniSTS:54377

RH12218 (e-PCR)
- UniSTS:15807

RH93673 (e-PCR)
- UniSTS:89321

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables microtubule binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament organization	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell morphogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of neuron differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of Rho protein signal transduction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info	PubMed
located_in ruffle membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: rho guanine nucleotide exchange factor 2

Names: Rho/Rac guanine nucleotide exchange factor (GEF) 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

NC_041754.1 Reference Mmul_10 Primary Assembly

Range

94972930..95042218

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_028827898.1 → XP_028683731.1 rho guanine nucleotide exchange factor 2 isoform X2

UniProtKB/TrEMBL

F7BYT9

Conserved Domains (4) summary

cd00029
Location:228 → 273

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00160
Location:423 → 617

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

TIGR02680
Location:988 → 1060

TIGR02680; TIGR02680 family protein

cd13393
Location:657 → 772

PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
XM_015111765.2 → XP_014967251.2 rho guanine nucleotide exchange factor 2 isoform X1

UniProtKB/TrEMBL

F7BYT9

Conserved Domains (4) summary

cd00029
Location:228 → 273

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00160
Location:424 → 618

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

TIGR02680
Location:989 → 1061

TIGR02680; TIGR02680 family protein

cd13393
Location:658 → 773

PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
XM_028827903.1 → XP_028683736.1 rho guanine nucleotide exchange factor 2 isoform X4

UniProtKB/TrEMBL

F7BYT9

Conserved Domains (4) summary

cd00029
Location:228 → 273

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00160
Location:423 → 617

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

TIGR02680
Location:988 → 1060

TIGR02680; TIGR02680 family protein

cd13393
Location:657 → 772

PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
XM_028827902.1 → XP_028683735.1 rho guanine nucleotide exchange factor 2 isoform X3

UniProtKB/TrEMBL

A0A5F8A0I2, F7BYT9

Related

ENSMMUP00000071407.1, ENSMMUT00000092104.1

Conserved Domains (4) summary

cd00029
Location:228 → 273

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00160
Location:424 → 618

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

TIGR02680
Location:989 → 1061

TIGR02680; TIGR02680 family protein

cd13393
Location:658 → 773

PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
XM_015111726.2 → XP_014967212.2 rho guanine nucleotide exchange factor 2 isoform X1

UniProtKB/TrEMBL

F7BYT9

Conserved Domains (4) summary

cd00029
Location:228 → 273

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00160
Location:424 → 618

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

TIGR02680
Location:989 → 1061

TIGR02680; TIGR02680 family protein

cd13393
Location:658 → 773

PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
XM_028827939.1 → XP_028683772.1 rho guanine nucleotide exchange factor 2 isoform X11

UniProtKB/TrEMBL

A0A5F7ZZE7

Conserved Domains (3) summary

cd00160
Location:221 → 415

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd13393
Location:455 → 570

PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain

cd20877
Location:20 → 80

C1_ARHGEF2; protein kinase C conserved region 1 (C1 domain) found in Rho guanine nucleotide exchange factor 2 (ARHGEF2) and similar proteins
XM_028827917.1 → XP_028683750.1 rho guanine nucleotide exchange factor 2 isoform X5

UniProtKB/TrEMBL

G7MDY2

Conserved Domains (4) summary

cd00029
Location:58 → 103

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00160
Location:254 → 448

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

TIGR02680
Location:819 → 891

TIGR02680; TIGR02680 family protein

cd13393
Location:488 → 603

PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
XM_015111805.2 → XP_014967291.2 rho guanine nucleotide exchange factor 2 isoform X12

UniProtKB/TrEMBL

A0A5F7ZZE7

Related

ENSMMUP00000067172.1, ENSMMUT00000086205.1

Conserved Domains (3) summary

cd00160
Location:209 → 403

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd13393
Location:443 → 558

PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain

cd20877
Location:8 → 68

C1_ARHGEF2; protein kinase C conserved region 1 (C1 domain) found in Rho guanine nucleotide exchange factor 2 (ARHGEF2) and similar proteins
XM_015111799.2 → XP_014967285.2 rho guanine nucleotide exchange factor 2 isoform X12

UniProtKB/TrEMBL

A0A5F7ZZE7

Conserved Domains (3) summary

cd00160
Location:209 → 403

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd13393
Location:443 → 558

PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain

cd20877
Location:8 → 68

C1_ARHGEF2; protein kinase C conserved region 1 (C1 domain) found in Rho guanine nucleotide exchange factor 2 (ARHGEF2) and similar proteins
XM_015111769.2 → XP_014967255.2 rho guanine nucleotide exchange factor 2 isoform X6

UniProtKB/TrEMBL

F7BYU7, H9EQY5

Related

ENSMMUP00000006755.4, ENSMMUT00000007188.4

Conserved Domains (4) summary

cd00029
Location:40 → 85

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00160
Location:236 → 430

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

TIGR02680
Location:801 → 873

TIGR02680; TIGR02680 family protein

cd13393
Location:470 → 585

PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
XM_015111774.2 → XP_014967260.2 rho guanine nucleotide exchange factor 2 isoform X7

UniProtKB/TrEMBL

H9EQY5

Conserved Domains (4) summary

cd00029
Location:40 → 85

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00160
Location:235 → 429

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

TIGR02680
Location:800 → 872

TIGR02680; TIGR02680 family protein

cd13393
Location:469 → 584

PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
XM_002801845.3 → XP_002801891.2 rho guanine nucleotide exchange factor 2 isoform X10

UniProtKB/TrEMBL

H9EQY5

Conserved Domains (4) summary

cd00029
Location:40 → 85

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00160
Location:235 → 429

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

TIGR02680
Location:800 → 872

TIGR02680; TIGR02680 family protein

cd13393
Location:469 → 584

PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
XM_015111790.2 → XP_014967276.2 rho guanine nucleotide exchange factor 2 isoform X9

UniProtKB/TrEMBL

H9EQY5, H9YUW1

Related

ENSMMUP00000066776.1, ENSMMUT00000095565.1

Conserved Domains (4) summary

cd00029
Location:40 → 85

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00160
Location:236 → 430

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

TIGR02680
Location:801 → 873

TIGR02680; TIGR02680 family protein

cd13393
Location:470 → 585

PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
XM_015111813.2 → XP_014967299.2 rho guanine nucleotide exchange factor 2 isoform X13

UniProtKB/TrEMBL

A0A5F7ZZE7

Conserved Domains (4) summary

cd00029
Location:13 → 58

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00160
Location:208 → 402

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

TIGR02680
Location:773 → 845

TIGR02680; TIGR02680 family protein

cd13393
Location:442 → 557

PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
XM_002801846.3 → XP_002801892.2 rho guanine nucleotide exchange factor 2 isoform X14

UniProtKB/TrEMBL

A0A5F7ZZE7

Conserved Domains (4) summary

cd00029
Location:13 → 58

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00160
Location:208 → 402

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

TIGR02680
Location:773 → 845

TIGR02680; TIGR02680 family protein

cd13393
Location:442 → 557

PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
XM_015111797.2 → XP_014967283.2 rho guanine nucleotide exchange factor 2 isoform X12

UniProtKB/TrEMBL

A0A5F7ZZE7

Conserved Domains (3) summary

cd00160
Location:209 → 403

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd13393
Location:443 → 558

PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain

cd20877
Location:8 → 68

C1_ARHGEF2; protein kinase C conserved region 1 (C1 domain) found in Rho guanine nucleotide exchange factor 2 (ARHGEF2) and similar proteins
XM_015111807.2 → XP_014967293.2 rho guanine nucleotide exchange factor 2 isoform X12

UniProtKB/TrEMBL

A0A5F7ZZE7

Related

ENSMMUP00000071040.1, ENSMMUT00000098818.1

Conserved Domains (3) summary

cd00160
Location:209 → 403

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd13393
Location:443 → 558

PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain

cd20877
Location:8 → 68

C1_ARHGEF2; protein kinase C conserved region 1 (C1 domain) found in Rho guanine nucleotide exchange factor 2 (ARHGEF2) and similar proteins
XM_015111780.2 → XP_014967266.2 rho guanine nucleotide exchange factor 2 isoform X8

UniProtKB/TrEMBL

F7BYW7

Related

ENSMMUP00000006751.4, ENSMMUT00000007184.4

Conserved Domains (4) summary

cd00029
Location:32 → 77

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00160
Location:228 → 422

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

TIGR02680
Location:793 → 865

TIGR02680; TIGR02680 family protein

cd13393
Location:462 → 577

PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain