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    HGF hepatocyte growth factor [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 708316, updated on 17-Aug-2024

    Summary

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    Official Symbol
    HGFprovided by VGNC
    Official Full Name
    hepatocyte growth factorprovided by VGNC
    Primary source
    VGNC:VGNC:73373
    See related
    Ensembl:ENSMMUG00000018652
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See HGF in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 3 NC_041756.1 (124391416..124463729)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 3 NC_027895.1 (112433343..112504014)

    Chromosome 3 - NC_041756.1Genomic Context describing neighboring genes Neighboring gene acyl-CoA desaturase pseudogene Neighboring gene calcium voltage-gated channel auxiliary subunit alpha2delta 1 Neighboring gene uncharacterized LOC114676996 Neighboring gene desmocollin-2-like Neighboring gene keratin 18-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in hepatocyte growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    hepatocyte growth factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041756.1 Reference Mmul_10 Primary Assembly

      Range
      124391416..124463729
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028846135.1 → XP_028701968.1  hepatocyte growth factor isoform X3

      UniProtKB/TrEMBL
      F7A5G3, G7MM01
      Related
      ENSMMUP00000024540.4, ENSMMUT00000026219.4
      Conserved Domains (5) summary
      smart00020
      Location:494 → 716
      Tryp_SPc; Trypsin-like serine protease
      smart00130
      Location:126 → 208
      KR; Kringle domain
      cd00108
      Location:388 → 470
      KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
      cd00129
      Location:39 → 122
      PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
      pfam00051
      Location:211 → 288
      Kringle; Kringle domain

    2. XM_028846134.1 → XP_028701967.1  hepatocyte growth factor isoform X1

      UniProtKB/TrEMBL
      F7A5F6, G7MM01
      Related
      ENSMMUP00000024541.4, ENSMMUT00000026220.4
      Conserved Domains (5) summary
      smart00020
      Location:554 → 776
      Tryp_SPc; Trypsin-like serine protease
      smart00130
      Location:186 → 268
      KR; Kringle domain
      cd00108
      Location:448 → 530
      KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
      cd00129
      Location:99 → 182
      PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
      pfam00051
      Location:271 → 348
      Kringle; Kringle domain

    3. XM_015134187.2 → XP_014989673.2  hepatocyte growth factor isoform X2

      UniProtKB/TrEMBL
      G7MM01
      Conserved Domains (5) summary
      smart00020
      Location:549 → 771
      Tryp_SPc; Trypsin-like serine protease
      smart00130
      Location:186 → 263
      KR; Kringle domain
      cd00108
      Location:443 → 525
      KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
      cd00129
      Location:99 → 182
      PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
      pfam00051
      Location:266 → 343
      Kringle; Kringle domain

    4. XM_015134186.2 → XP_014989672.1  hepatocyte growth factor isoform X3

      UniProtKB/TrEMBL
      F7A5G3, G7MM01
      Conserved Domains (5) summary
      smart00020
      Location:494 → 716
      Tryp_SPc; Trypsin-like serine protease
      smart00130
      Location:126 → 208
      KR; Kringle domain
      cd00108
      Location:388 → 470
      KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
      cd00129
      Location:39 → 122
      PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
      pfam00051
      Location:211 → 288
      Kringle; Kringle domain

    5. XM_028846136.1 → XP_028701969.1  hepatocyte growth factor isoform X3

      UniProtKB/TrEMBL
      F7A5G3, G7MM01
      Conserved Domains (5) summary
      smart00020
      Location:494 → 716
      Tryp_SPc; Trypsin-like serine protease
      smart00130
      Location:126 → 208
      KR; Kringle domain
      cd00108
      Location:388 → 470
      KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
      cd00129
      Location:39 → 122
      PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
      pfam00051
      Location:211 → 288
      Kringle; Kringle domain
    Nucleotide Protein
    Heading Accession and Version

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