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    TJP2 tight junction protein 2 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 699586, updated on 17-Aug-2024

    Summary

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    Official Symbol
    TJP2provided by VGNC
    Official Full Name
    tight junction protein 2provided by VGNC
    Primary source
    VGNC:VGNC:112121
    See related
    Ensembl:ENSMMUG00000003780
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See TJP2 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 15 NC_041768.1 (84575055..84714613)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 15 NC_027907.1 (85328688..85469531)

    Chromosome 15 - NC_041768.1Genomic Context describing neighboring genes Neighboring gene protein kinase cAMP-activated catalytic subunit gamma Neighboring gene frataxin Neighboring gene endosomal transmembrane epsin interactor 1 Neighboring gene uncharacterized LOC114672808 Neighboring gene uncharacterized LOC114672810 Neighboring gene amyloid beta precursor protein binding family A member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cell adhesion molecule binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell-cell junction organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in establishment of endothelial intestinal barrier IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of blood-brain barrier permeability IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein localization to cell-cell junction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tight junction protein ZO-2
    Names
    tight junction protein ZO-2-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041768.1 Reference Mmul_10 Primary Assembly

      Range
      84575055..84714613
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015117863.2 → XP_014973349.1  tight junction protein ZO-2 isoform X7

      UniProtKB/TrEMBL
      I2CXW9
      Conserved Domains (7) summary
      cd12027
      Location:579 → 641
      SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
      smart00072
      Location:675 → 854
      GuKc; Guanylate kinase homologues
      COG0265
      Location:277 → 367
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:9 → 94
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00595
      Location:274 → 357
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam08648
      Location:126 → 237
      DUF1777; Protein of unknown function (DUF1777)
      pfam12871
      Location:118 → 197
      PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term

    2. XM_015117858.2 → XP_014973344.2  tight junction protein ZO-2 isoform X3

      UniProtKB/TrEMBL
      A0A1D5Q924, I2CXW8
      Related
      ENSMMUP00000044542.2, ENSMMUT00000065139.2
      Conserved Domains (6) summary
      cd12027
      Location:579 → 641
      SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
      smart00072
      Location:675 → 854
      GuKc; Guanylate kinase homologues
      cd00992
      Location:9 → 94
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR01622
      Location:160 → 274
      SF-CC1; splicing factor, CC1-like family
      TIGR01642
      Location:121 → 203
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      pfam00595
      Location:274 → 357
      PDZ; PDZ domain (Also known as DHR or GLGF)

    3. XM_015117862.2 → XP_014973348.1  tight junction protein ZO-2 isoform X6

      UniProtKB/TrEMBL
      F7GVN1, I2CXW9
      Related
      ENSMMUP00000005040.4, ENSMMUT00000005352.4
      Conserved Domains (6) summary
      cd12027
      Location:602 → 664
      SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
      smart00072
      Location:698 → 877
      GuKc; Guanylate kinase homologues
      cd00992
      Location:32 → 117
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR01622
      Location:183 → 297
      SF-CC1; splicing factor, CC1-like family
      TIGR01642
      Location:144 → 226
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      pfam00595
      Location:297 → 380
      PDZ; PDZ domain (Also known as DHR or GLGF)

    4. XM_015117857.2 → XP_014973343.2  tight junction protein ZO-2 isoform X2

      UniProtKB/TrEMBL
      H9G213, I2CXW8
      Conserved Domains (6) summary
      cd12027
      Location:602 → 664
      SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
      smart00072
      Location:698 → 877
      GuKc; Guanylate kinase homologues
      cd00992
      Location:32 → 117
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR01622
      Location:183 → 297
      SF-CC1; splicing factor, CC1-like family
      TIGR01642
      Location:144 → 226
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      pfam00595
      Location:297 → 380
      PDZ; PDZ domain (Also known as DHR or GLGF)

    5. XM_015117855.2 → XP_014973341.2  tight junction protein ZO-2 isoform X1

      UniProtKB/TrEMBL
      A0A1D5QPT5, H9G212
      Related
      ENSMMUP00000050062.2, ENSMMUT00000057863.2
      Conserved Domains (6) summary
      cd12027
      Location:606 → 668
      SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
      smart00072
      Location:702 → 881
      GuKc; Guanylate kinase homologues
      cd00992
      Location:36 → 121
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR01622
      Location:187 → 301
      SF-CC1; splicing factor, CC1-like family
      TIGR01642
      Location:148 → 230
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      pfam00595
      Location:301 → 384
      PDZ; PDZ domain (Also known as DHR or GLGF)

    6. XM_015117861.2 → XP_014973347.1  tight junction protein ZO-2 isoform X5

      UniProtKB/TrEMBL
      A0A1D5QPT5, A0A5F7ZAY2
      Related
      ENSMMUP00000062339.1, ENSMMUT00000108180.1
      Conserved Domains (7) summary
      cd12027
      Location:606 → 668
      SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
      smart00072
      Location:702 → 881
      GuKc; Guanylate kinase homologues
      COG0265
      Location:304 → 394
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:36 → 121
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00595
      Location:301 → 384
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam08648
      Location:153 → 264
      DUF1777; Protein of unknown function (DUF1777)
      pfam12871
      Location:145 → 224
      PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term

    7. XM_015117860.2 → XP_014973346.2  tight junction protein ZO-2 isoform X4

      UniProtKB/TrEMBL
      A0A1D5QPT5, F7F8F4, H9G215
      Related
      ENSMMUP00000009026.4, ENSMMUT00000009605.4
      Conserved Domains (6) summary
      cd12027
      Location:606 → 668
      SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
      smart00072
      Location:702 → 881
      GuKc; Guanylate kinase homologues
      cd00992
      Location:36 → 121
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR01622
      Location:187 → 301
      SF-CC1; splicing factor, CC1-like family
      TIGR01642
      Location:148 → 230
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      pfam00595
      Location:301 → 384
      PDZ; PDZ domain (Also known as DHR or GLGF)
    Nucleotide Protein
    Heading Accession and Version

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