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    GRAP2 GRB2 related adaptor protein 2 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 704410, updated on 17-Aug-2024

    Summary

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    Official Symbol
    GRAP2provided by VGNC
    Official Full Name
    GRB2 related adaptor protein 2provided by VGNC
    Primary source
    VGNC:VGNC:73156
    Locus tag
    EGK_03067
    See related
    Ensembl:ENSMMUG00000004880
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See GRAP2 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 10 NC_041763.1 (11567337..11645561, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 10 NC_027902.1 (81899231..81977447)

    Chromosome 10 - NC_041763.1Genomic Context describing neighboring genes Neighboring gene trinucleotide repeat containing adaptor 6B Neighboring gene microRNA mir-7204 Neighboring gene family with sequence similarity 83 member F Neighboring gene ENTH domain containing 1 Neighboring gene mitochondrial fission regulator 2-like Neighboring gene uncharacterized LOC114670586

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol, 2011 Oct 16. PMID 22002653
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of ESCRT-0 complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    GRB2-related adapter protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001261710.1 → NP_001248639.1  GRB2-related adapter protein 2

      See identical proteins and their annotated locations for NP_001248639.1

      Status: PROVISIONAL

      Source sequence(s)
      JU471070
      UniProtKB/TrEMBL
      A0A8J8Y7W2, F7AN37, G7N3X1
      Related
      ENSMMUP00000069268.1, ENSMMUT00000087608.1
      Conserved Domains (3) summary
      cd09941
      Location:54 → 147
      SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
      cd11947
      Location:2 → 53
      SH3_GRAP2_N; N-terminal Src homology 3 domain of GRB2-related adaptor protein 2
      cd11950
      Location:275 → 327
      SH3_GRAP2_C; C-terminal Src homology 3 domain of GRB2-related adaptor protein 2

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041763.1 Reference Mmul_10 Primary Assembly

      Range
      11567337..11645561 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015150335.2 → XP_015005821.1  GRB2-related adapter protein 2 isoform X5

      UniProtKB/TrEMBL
      A0A8J8Y7W2, F7AN37, G7N3X1
      Related
      ENSMMUP00000006488.2, ENSMMUT00000006896.4
      Conserved Domains (3) summary
      cd09941
      Location:54 → 147
      SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
      cd11947
      Location:2 → 53
      SH3_GRAP2_N; N-terminal Src homology 3 domain of GRB2-related adaptor protein 2
      cd11950
      Location:275 → 327
      SH3_GRAP2_C; C-terminal Src homology 3 domain of GRB2-related adaptor protein 2

    2. XM_028827277.1 → XP_028683110.1  GRB2-related adapter protein 2 isoform X4

      Conserved Domains (3) summary
      cd09941
      Location:76 → 169
      SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
      cd11950
      Location:297 → 349
      SH3_GRAP2_C; C-terminal Src homology 3 domain of GRB2-related adaptor protein 2
      cl17036
      Location:48 → 75
      SH3; Src Homology 3 domain superfamily

    3. XM_028827276.1 → XP_028683109.1  GRB2-related adapter protein 2 isoform X3

      Conserved Domains (3) summary
      cd09941
      Location:77 → 170
      SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
      cd11950
      Location:298 → 350
      SH3_GRAP2_C; C-terminal Src homology 3 domain of GRB2-related adaptor protein 2
      cl17036
      Location:49 → 76
      SH3; Src Homology 3 domain superfamily

    4. XM_028827275.1 → XP_028683108.1  GRB2-related adapter protein 2 isoform X3

      Related
      ENSMMUP00000065157.1, ENSMMUT00000102127.1
      Conserved Domains (3) summary
      cd09941
      Location:77 → 170
      SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
      cd11950
      Location:298 → 350
      SH3_GRAP2_C; C-terminal Src homology 3 domain of GRB2-related adaptor protein 2
      cl17036
      Location:49 → 76
      SH3; Src Homology 3 domain superfamily

    5. XM_028827278.1 → XP_028683111.1  GRB2-related adapter protein 2 isoform X6

      Conserved Domains (2) summary
      cd09941
      Location:3 → 75
      SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
      cd11950
      Location:203 → 255
      SH3_GRAP2_C; C-terminal Src homology 3 domain of GRB2-related adaptor protein 2

    6. XM_015150334.2 → XP_015005820.1  GRB2-related adapter protein 2 isoform X5

      UniProtKB/TrEMBL
      A0A8J8Y7W2, F7AN37, G7N3X1
      Conserved Domains (3) summary
      cd09941
      Location:54 → 147
      SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
      cd11947
      Location:2 → 53
      SH3_GRAP2_N; N-terminal Src homology 3 domain of GRB2-related adaptor protein 2
      cd11950
      Location:275 → 327
      SH3_GRAP2_C; C-terminal Src homology 3 domain of GRB2-related adaptor protein 2

    7. XM_028827274.1 → XP_028683107.1  GRB2-related adapter protein 2 isoform X1

      Conserved Domains (3) summary
      cd09941
      Location:146 → 239
      SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
      cd11950
      Location:367 → 419
      SH3_GRAP2_C; C-terminal Src homology 3 domain of GRB2-related adaptor protein 2
      cl17036
      Location:118 → 145
      SH3; Src Homology 3 domain superfamily

    8. XM_015150331.2 → XP_015005817.1  GRB2-related adapter protein 2 isoform X2

      Conserved Domains (3) summary
      cd09941
      Location:79 → 172
      SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
      cd11947
      Location:27 → 78
      SH3_GRAP2_N; N-terminal Src homology 3 domain of GRB2-related adaptor protein 2
      cd11950
      Location:300 → 352
      SH3_GRAP2_C; C-terminal Src homology 3 domain of GRB2-related adaptor protein 2

    9. XM_015150337.2 → XP_015005823.1  GRB2-related adapter protein 2 isoform X6

      Conserved Domains (2) summary
      cd09941
      Location:3 → 75
      SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
      cd11950
      Location:203 → 255
      SH3_GRAP2_C; C-terminal Src homology 3 domain of GRB2-related adaptor protein 2

    10. XM_015150338.2 → XP_015005824.1  GRB2-related adapter protein 2 isoform X7

      Conserved Domains (1) summary
      cd11950
      Location:162 → 214
      SH3_GRAP2_C; C-terminal Src homology 3 domain of GRB2-related adaptor protein 2
    Nucleotide Protein
    Heading Accession and Version

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