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    IGF1R insulin like growth factor 1 receptor [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 708227, updated on 17-Aug-2024

    Summary

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    Official Symbol
    IGF1Rprovided by VGNC
    Official Full Name
    insulin like growth factor 1 receptorprovided by VGNC
    Primary source
    VGNC:VGNC:82162
    Locus tag
    EGK_17876
    See related
    Ensembl:ENSMMUG00000012305
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See IGF1R in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 7 NC_041760.1 (77827465..78139764)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 7 NC_027899.1 (77277684..77594375)

    Chromosome 7 - NC_041760.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC114679511 Neighboring gene Protein FAM169B Neighboring gene mitochondrial import receptor subunit TOM20 homolog Neighboring gene uncharacterized LOC114679513 Neighboring gene uncharacterized LOC114679514 Neighboring gene pyroglutamyl-peptidase I like Neighboring gene uncharacterized LOC106999323

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol, 2011 Oct 16. PMID 22002653
    2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables insulin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables insulin receptor substrate binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables phosphatidylinositol 3-kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glucose homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in insulin-like growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein autophosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of JNK cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of insulin receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    insulin-like growth factor 1 receptor
    NP_001248281.1
    XP_014998605.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001261352.1 → NP_001248281.1  insulin-like growth factor 1 receptor precursor

      See identical proteins and their annotated locations for NP_001248281.1

      Status: PROVISIONAL

      Source sequence(s)
      JV046962
      UniProtKB/TrEMBL
      A0A8J8Y4S9, F7DLC9, G7MWA6, I2CWY3
      Related
      ENSMMUP00000016141.3, ENSMMUT00000017236.3
      Conserved Domains (6) summary
      cd05032
      Location:992 → 1268
      PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
      cd00063
      Location:835 → 924
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00064
      Location:230 → 277
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam00757
      Location:175 → 330
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:352 → 466
      Recep_L_domain; Receptor L domain
      pfam07714
      Location:999 → 1266
      Pkinase_Tyr; Protein tyrosine kinase

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041760.1 Reference Mmul_10 Primary Assembly

      Range
      77827465..78139764
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015143119.2 → XP_014998605.1  insulin-like growth factor 1 receptor isoform X1

      Conserved Domains (6) summary
      cd05032
      Location:991 → 1267
      PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
      cd00063
      Location:835 → 924
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00064
      Location:230 → 277
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam00757
      Location:175 → 330
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:352 → 466
      Recep_L_domain; Receptor L domain
      pfam07714
      Location:998 → 1265
      Pkinase_Tyr; Protein tyrosine kinase
    Nucleotide Protein
    Heading Accession and Version

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