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    GRIA1 glutamate ionotropic receptor AMPA type subunit 1 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 714117, updated on 17-Aug-2024

    Summary

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    Official Symbol
    GRIA1provided by VGNC
    Official Full Name
    glutamate ionotropic receptor AMPA type subunit 1provided by VGNC
    Primary source
    VGNC:VGNC:73271
    Locus tag
    EGK_17050
    See related
    Ensembl:ENSMMUG00000009287
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See GRIA1 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 6 NC_041759.1 (150882479..151205169)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 6 NC_027898.1 (151524991..151898832)

    Chromosome 6 - NC_041759.1Genomic Context describing neighboring genes Neighboring gene neuromedin U receptor 2 Neighboring gene uncharacterized LOC106999008 Neighboring gene uncharacterized LOC114678716 Neighboring gene family with sequence similarity 114 member A2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CircGRIA1 shows an age-related increase in male macaque brain and regulates synaptic plasticity and synaptogenesis. Xu K, et al. Nat Commun, 2020 Jul 17. PMID 32681011, Free PMC Article
    2. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol, 2011 Oct 16. PMID 22002653
    3. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CircGRIA1 shows an age-related increase in male macaque brain and regulates synaptic plasticity and synaptogenesis.
      Title: CircGRIA1 shows an age-related increase in male macaque brain and regulates synaptic plasticity and synaptogenesis.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables AMPA glutamate receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in modulation of chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in synaptic transmission, glutamatergic IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of AMPA glutamate receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in dendritic spine IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glutamate receptor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001265785.2 → NP_001252714.1  glutamate receptor 1 precursor

      See identical proteins and their annotated locations for NP_001252714.1

      Status: PROVISIONAL

      Source sequence(s)
      JV489087
      UniProtKB/TrEMBL
      A0A1D5RJF9, A0A5S6RCE4, A0A8J8YG09, F7H3T9, G7MVP5
      Related
      ENSMMUP00000012165.4, ENSMMUT00000012979.4
      Conserved Domains (2) summary
      cd13729
      Location:406 → 787
      PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      cd06390
      Location:26 → 392
      PBP1_iGluR_AMPA_GluR1; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR1 subunit of the AMPA receptor

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041759.1 Reference Mmul_10 Primary Assembly

      Range
      150882479..151205169
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028849273.1 → XP_028705106.1  glutamate receptor 1 isoform X2

      UniProtKB/TrEMBL
      A0A1D5RJF9
      Related
      ENSMMUP00000060453.1, ENSMMUT00000077656.2
      Conserved Domains (2) summary
      cd06390
      Location:9 → 369
      PBP1_iGluR_AMPA_GluR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR1 subunit of the AMPA receptor
      cd13729
      Location:386 → 767
      PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

    2. XM_015141276.2 → XP_014996762.1  glutamate receptor 1 isoform X1

      UniProtKB/TrEMBL
      A0A1D5RJF9
      Related
      ENSMMUP00000055691.2, ENSMMUT00000059249.2
      Conserved Domains (2) summary
      cd13729
      Location:406 → 787
      PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      cd06390
      Location:26 → 392
      PBP1_iGluR_AMPA_GluR1; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR1 subunit of the AMPA receptor

    RNA

    1. XR_003730114.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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