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    MMP9 matrix metallopeptidase 9 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 708084, updated on 17-Aug-2024

    Summary

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    Official Symbol
    MMP9provided by VGNC
    Official Full Name
    matrix metallopeptidase 9provided by VGNC
    Primary source
    VGNC:VGNC:74903
    Locus tag
    EGK_02336
    See related
    Ensembl:ENSMMUG00000016549
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See MMP9 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 10 NC_041763.1 (81199354..81207515)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 10 NC_027902.1 (18482723..18490539, complement)

    Chromosome 10 - NC_041763.1Genomic Context describing neighboring genes Neighboring gene cathepsin A Neighboring gene phospholipid transfer protein Neighboring gene phosphorylated CTD interacting factor 1 Neighboring gene zinc finger protein 335 Neighboring gene solute carrier family 12 member 5 Neighboring gene nuclear receptor coactivator 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. IGF2, IGF binding protein 1, and matrix metalloproteinases 2 and 9 in implantation-stage endometrium following immunoneutralization of vascular endothelial growth factor in the rhesus monkey. Ghosh D, et al. Reproduction, 2011 Apr. PMID 21292726
    2. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol, 2011 Oct 16. PMID 22002653
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A functional network involving VEGF, IGF2, and MMP9 in early placental trophoblast cells and maternal endometrium appears to be important for normal placentation.
      Title: IGF2, IGF binding protein 1, and matrix metalloproteinases 2 and 9 in implantation-stage endometrium following immunoneutralization of vascular endothelial growth factor in the rhesus monkey.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in collagen catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in extracellular matrix organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    matrix metalloproteinase-9
    Names
    matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
    matrix metalloproteinase-9 preproprotein
    NP_001253834.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001266905.1 → NP_001253834.1  matrix metalloproteinase-9 precursor

      See identical proteins and their annotated locations for NP_001253834.1

      Status: PROVISIONAL

      Source sequence(s)
      JU475656
      UniProtKB/TrEMBL
      A0A8J8Y654, F6W5A7, G7N4M8, H9Z944
      Related
      ENSMMUP00000021747.3, ENSMMUT00000023244.4
      Conserved Domains (6) summary
      smart00059
      Location:223 → 271
      FN2; Fibronectin type 2 domain
      cd00094
      Location:514 → 704
      HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
      cd04278
      Location:115 → 444
      ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
      pfam00040
      Location:347 → 388
      fn2; Fibronectin type II domain
      pfam00413
      Location:115 → 444
      Peptidase_M10; Matrixin
      pfam04886
      Location:472 → 502
      PT; PT repeat

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041763.1 Reference Mmul_10 Primary Assembly

      Range
      81199354..81207515
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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    Research Materials