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    HUWE1 HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 700136, updated on 17-Aug-2024

    Summary

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    Official Symbol
    HUWE1provided by VGNC
    Official Full Name
    HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1provided by VGNC
    Primary source
    VGNC:VGNC:73462
    See related
    Ensembl:ENSMMUG00000006362
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See HUWE1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    90
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) X NC_041774.1 (53263348..53417017, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) X NC_027913.1 (52939857..53092970, complement)

    Chromosome X - NC_041774.1Genomic Context describing neighboring genes Neighboring gene hydroxysteroid 17-beta dehydrogenase 10 Neighboring gene TIMELESS-interacting protein pseudogene Neighboring gene microRNA let-7f-2 Neighboring gene microRNA mir-98 Neighboring gene 39S ribosomal protein L32, mitochondrial pseudogene Neighboring gene 28S ribosomal protein S18c, mitochondrial pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in membrane fusion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein polyubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase HUWE1
    Names
    HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
    NP_001253681.1
    XP_014982950.2
    XP_028697552.1
    XP_028697553.1
    XP_028697554.1
    XP_028697555.1
    XP_028697556.1
    XP_028697557.1
    XP_028697558.1
    XP_028697559.1
    XP_028697560.1
    XP_028697561.1
    XP_028697562.1
    XP_028697563.1
    XP_028697564.1
    XP_028697565.1
    XP_028697566.1
    XP_028697567.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001266752.1 → NP_001253681.1  E3 ubiquitin-protein ligase HUWE1

      See identical proteins and their annotated locations for NP_001253681.1

      Status: PROVISIONAL

      Source sequence(s)
      JV043380
      UniProtKB/TrEMBL
      F7HBR6, G7NRH6, H9ELS9
      Related
      ENSMMUP00000008397.3, ENSMMUT00000008929.4
      Conserved Domains (7) summary
      cd00078
      Location:4019 → 4372
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1317 → 1356
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam05466
      Location:2699 → 2916
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
      pfam02825
      Location:1617 → 1678
      WWE; WWE domain
      pfam06012
      Location:92 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:430 → 814
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:2968 → 3077
      DUF4414; Domain of unknown function (DUF4414)

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041774.1 Reference Mmul_10 Primary Assembly

      Range
      53263348..53417017 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028841719.1 → XP_028697552.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

      UniProtKB/TrEMBL
      G7NRH6
      Conserved Domains (7) summary
      cd00078
      Location:4100 → 4453
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1398 → 1437
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam05109
      Location:2803 → 3039
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam02825
      Location:1698 → 1759
      WWE; WWE domain
      pfam06012
      Location:92 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:431 → 895
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3091 → 3122
      DUF4414; Domain of unknown function (DUF4414)

    2. XM_028841728.1 → XP_028697561.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

      UniProtKB/TrEMBL
      G7NRH6
      Conserved Domains (7) summary
      cd00078
      Location:4100 → 4453
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1398 → 1437
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam05109
      Location:2803 → 3039
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam02825
      Location:1698 → 1759
      WWE; WWE domain
      pfam06012
      Location:92 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:431 → 895
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3091 → 3122
      DUF4414; Domain of unknown function (DUF4414)

    3. XM_028841733.1 → XP_028697566.1  E3 ubiquitin-protein ligase HUWE1 isoform X6

      UniProtKB/TrEMBL
      F7HBR6, G7NRH6, H9ELS9
      Conserved Domains (7) summary
      cd00078
      Location:4019 → 4372
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1317 → 1356
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam05466
      Location:2699 → 2916
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
      pfam02825
      Location:1617 → 1678
      WWE; WWE domain
      pfam06012
      Location:92 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:430 → 814
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:2968 → 3077
      DUF4414; Domain of unknown function (DUF4414)

    4. XM_028841729.1 → XP_028697562.1  E3 ubiquitin-protein ligase HUWE1 isoform X2

      UniProtKB/TrEMBL
      G7NRH6
      Conserved Domains (7) summary
      cd00078
      Location:4099 → 4452
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1398 → 1437
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam05466
      Location:2779 → 2996
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
      pfam02825
      Location:1698 → 1759
      WWE; WWE domain
      pfam06012
      Location:92 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:430 → 895
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3048 → 3157
      DUF4414; Domain of unknown function (DUF4414)

    5. XM_028841734.1 → XP_028697567.1  E3 ubiquitin-protein ligase HUWE1 isoform X7

      UniProtKB/TrEMBL
      A0A1D5RHP8
      Related
      ENSMMUP00000059842.2, ENSMMUT00000061110.2
      Conserved Domains (7) summary
      cd00078
      Location:3966 → 4319
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1398 → 1437
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam05466
      Location:2646 → 2863
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
      pfam02825
      Location:1698 → 1759
      WWE; WWE domain
      pfam06012
      Location:92 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:430 → 895
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:2915 → 3024
      DUF4414; Domain of unknown function (DUF4414)

    6. XM_028841731.1 → XP_028697564.1  E3 ubiquitin-protein ligase HUWE1 isoform X4

      UniProtKB/TrEMBL
      G7NRH6
      Conserved Domains (7) summary
      PHA03247
      Location:2822 → 3191
      PHA03247; large tegument protein UL36; Provisional
      cd00078
      Location:4084 → 4437
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1398 → 1437
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1698 → 1759
      WWE; WWE domain
      pfam06012
      Location:92 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:430 → 895
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3049 → 3142
      DUF4414; Domain of unknown function (DUF4414)

    7. XM_028841730.1 → XP_028697563.1  E3 ubiquitin-protein ligase HUWE1 isoform X3

      UniProtKB/TrEMBL
      G7NRH6
      Conserved Domains (7) summary
      cd00078
      Location:4085 → 4438
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1398 → 1437
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam05466
      Location:2780 → 2997
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
      pfam02825
      Location:1698 → 1759
      WWE; WWE domain
      pfam06012
      Location:92 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:430 → 895
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3049 → 3158
      DUF4414; Domain of unknown function (DUF4414)

    8. XM_028841727.1 → XP_028697560.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

      UniProtKB/TrEMBL
      G7NRH6
      Conserved Domains (7) summary
      cd00078
      Location:4100 → 4453
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1398 → 1437
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam05109
      Location:2803 → 3039
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam02825
      Location:1698 → 1759
      WWE; WWE domain
      pfam06012
      Location:92 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:431 → 895
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3091 → 3122
      DUF4414; Domain of unknown function (DUF4414)

    9. XM_015127464.2 → XP_014982950.2  E3 ubiquitin-protein ligase HUWE1 isoform X1

      UniProtKB/TrEMBL
      G7NRH6
      Conserved Domains (7) summary
      cd00078
      Location:4100 → 4453
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1398 → 1437
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam05109
      Location:2803 → 3039
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam02825
      Location:1698 → 1759
      WWE; WWE domain
      pfam06012
      Location:92 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:431 → 895
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3091 → 3122
      DUF4414; Domain of unknown function (DUF4414)

    10. XM_028841725.1 → XP_028697558.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

      UniProtKB/TrEMBL
      G7NRH6
      Conserved Domains (7) summary
      cd00078
      Location:4100 → 4453
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1398 → 1437
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam05109
      Location:2803 → 3039
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam02825
      Location:1698 → 1759
      WWE; WWE domain
      pfam06012
      Location:92 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:431 → 895
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3091 → 3122
      DUF4414; Domain of unknown function (DUF4414)

    11. XM_028841726.1 → XP_028697559.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

      UniProtKB/TrEMBL
      G7NRH6
      Conserved Domains (7) summary
      cd00078
      Location:4100 → 4453
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1398 → 1437
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam05109
      Location:2803 → 3039
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam02825
      Location:1698 → 1759
      WWE; WWE domain
      pfam06012
      Location:92 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:431 → 895
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3091 → 3122
      DUF4414; Domain of unknown function (DUF4414)

    12. XM_028841724.1 → XP_028697557.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

      UniProtKB/TrEMBL
      G7NRH6
      Conserved Domains (7) summary
      cd00078
      Location:4100 → 4453
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1398 → 1437
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam05109
      Location:2803 → 3039
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam02825
      Location:1698 → 1759
      WWE; WWE domain
      pfam06012
      Location:92 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:431 → 895
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3091 → 3122
      DUF4414; Domain of unknown function (DUF4414)

    13. XM_028841722.1 → XP_028697555.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

      UniProtKB/TrEMBL
      G7NRH6
      Conserved Domains (7) summary
      cd00078
      Location:4100 → 4453
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1398 → 1437
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam05109
      Location:2803 → 3039
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam02825
      Location:1698 → 1759
      WWE; WWE domain
      pfam06012
      Location:92 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:431 → 895
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3091 → 3122
      DUF4414; Domain of unknown function (DUF4414)

    14. XM_028841723.1 → XP_028697556.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

      UniProtKB/TrEMBL
      G7NRH6
      Conserved Domains (7) summary
      cd00078
      Location:4100 → 4453
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1398 → 1437
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam05109
      Location:2803 → 3039
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam02825
      Location:1698 → 1759
      WWE; WWE domain
      pfam06012
      Location:92 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:431 → 895
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3091 → 3122
      DUF4414; Domain of unknown function (DUF4414)

    15. XM_028841720.1 → XP_028697553.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

      UniProtKB/TrEMBL
      G7NRH6
      Conserved Domains (7) summary
      cd00078
      Location:4100 → 4453
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1398 → 1437
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam05109
      Location:2803 → 3039
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam02825
      Location:1698 → 1759
      WWE; WWE domain
      pfam06012
      Location:92 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:431 → 895
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3091 → 3122
      DUF4414; Domain of unknown function (DUF4414)

    16. XM_028841721.1 → XP_028697554.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

      UniProtKB/TrEMBL
      G7NRH6
      Conserved Domains (7) summary
      cd00078
      Location:4100 → 4453
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1398 → 1437
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam05109
      Location:2803 → 3039
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam02825
      Location:1698 → 1759
      WWE; WWE domain
      pfam06012
      Location:92 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:431 → 895
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3091 → 3122
      DUF4414; Domain of unknown function (DUF4414)

    17. XM_028841732.1 → XP_028697565.1  E3 ubiquitin-protein ligase HUWE1 isoform X5

      UniProtKB/TrEMBL
      G7NRH6
      Conserved Domains (7) summary
      PHA03247
      Location:2821 → 3190
      PHA03247; large tegument protein UL36; Provisional
      cd00078
      Location:4083 → 4436
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1398 → 1437
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1698 → 1759
      WWE; WWE domain
      pfam06012
      Location:92 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:430 → 895
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3048 → 3141
      DUF4414; Domain of unknown function (DUF4414)
    Nucleotide Protein
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    Gene LinkOut

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