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    IDE insulin degrading enzyme [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 698640, updated on 17-Aug-2024

    Summary

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    Official Symbol
    IDEprovided by VGNC
    Official Full Name
    insulin degrading enzymeprovided by VGNC
    Primary source
    VGNC:VGNC:73558
    See related
    Ensembl:ENSMMUG00000023267
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See IDE in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 9 NC_041762.1 (92615266..92735437, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 9 NC_027901.1 (87677012..87796932, complement)

    Chromosome 9 - NC_041762.1Genomic Context describing neighboring genes Neighboring gene cytoplasmic polyadenylation element binding protein 3 Neighboring gene membrane associated ring-CH-type finger 5 Neighboring gene uncharacterized LOC107000223 Neighboring gene deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial pseudogene Neighboring gene kinesin family member 11 Neighboring gene eukaryotic translation initiation factor 2 subunit 2-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in peptide catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in proteolysis involved in protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in peroxisomal matrix IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    insulin-degrading enzyme
    NP_001245003.1
    XP_015003117.2
    XP_015003119.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001258074.1 → NP_001245003.1  insulin-degrading enzyme

      See identical proteins and their annotated locations for NP_001245003.1

      Status: PROVISIONAL

      Source sequence(s)
      JU475427
      UniProtKB/TrEMBL
      H9F951, H9Z8G5
      Related
      ENSMMUP00000035769.3, ENSMMUT00000042759.3
      Conserved Domains (4) summary
      COG1025
      Location:52 → 958
      Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]
      pfam00675
      Location:74 → 212
      Peptidase_M16; Insulinase (Peptidase family M16)
      pfam05193
      Location:238 → 416
      Peptidase_M16_C; Peptidase M16 inactive domain
      pfam16187
      Location:422 → 703
      Peptidase_M16_M; Middle or third domain of peptidase_M16

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041762.1 Reference Mmul_10 Primary Assembly

      Range
      92615266..92735437 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015147631.2 → XP_015003117.2  insulin-degrading enzyme isoform X1

      UniProtKB/TrEMBL
      F7EFM6, H9F951
      Related
      ENSMMUP00000035767.3, ENSMMUT00000042757.3
      Conserved Domains (1) summary
      COG1025
      Location:52 → 958
      Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]

    2. XM_015147633.2 → XP_015003119.2  insulin-degrading enzyme isoform X2

      UniProtKB/TrEMBL
      F7FKF0, H9F951
      Related
      ENSMMUP00000030629.3, ENSMMUT00000032733.4
      Conserved Domains (1) summary
      COG1025
      Location:52 → 940
      Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version

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