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    TRAF3 TNF receptor associated factor 3 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 693961, updated on 17-Aug-2024

    Summary

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    Official Symbol
    TRAF3provided by VGNC
    Official Full Name
    TNF receptor associated factor 3provided by VGNC
    Primary source
    VGNC:VGNC:78642
    See related
    Ensembl:ENSMMUG00000011752
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See TRAF3 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 7 NC_041760.1 (165055623..165195852)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 7 NC_027899.1 (165116409..165201778)

    Chromosome 7 - NC_041760.1Genomic Context describing neighboring genes Neighboring gene REST corepressor 1 Neighboring gene 60S ribosomal protein L23a pseudogene Neighboring gene nudC domain-containing protein 2 Neighboring gene small nucleolar RNA U13 Neighboring gene U6 spliceosomal RNA Neighboring gene secretogranin V (7B2 protein) pseudogene Neighboring gene CDC42 binding protein kinase beta Neighboring gene amnion associated transmembrane protein Neighboring gene 60S ribosomal protein L13 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables tumor necrosis factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Toll signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of NF-kappaB transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of JNK cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein K63-linked ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cytokine production IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of defense response to virus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in tumor necrosis factor-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of plasma membrane signaling receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    TNF receptor-associated factor 3
    XP_015000016.1
    XP_028707710.1
    XP_028707711.1
    XP_028707712.1
    XP_028707713.1
    XP_028707714.1
    XP_028707715.1
    XP_028707716.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041760.1 Reference Mmul_10 Primary Assembly

      Range
      165055623..165195852
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028851880.1 → XP_028707713.1  TNF receptor-associated factor 3 isoform X1

      UniProtKB/TrEMBL
      A0A1D5RF63, H9FZ66
      Related
      ENSMMUP00000058957.2, ENSMMUT00000066619.2
      Conserved Domains (4) summary
      COG1196
      Location:252 → 433
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd03777
      Location:378 → 563
      MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
      pfam02176
      Location:136 → 192
      zf-TRAF; TRAF-type zinc finger
      cd16640
      Location:51 → 92
      RING-HC_TRAF3; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) and similar proteins

    2. XM_028851877.1 → XP_028707710.1  TNF receptor-associated factor 3 isoform X1

      UniProtKB/TrEMBL
      A0A1D5RF63, H9FZ66
      Related
      ENSMMUP00000066374.1, ENSMMUT00000095782.1
      Conserved Domains (4) summary
      COG1196
      Location:252 → 433
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd03777
      Location:378 → 563
      MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
      pfam02176
      Location:136 → 192
      zf-TRAF; TRAF-type zinc finger
      cd16640
      Location:51 → 92
      RING-HC_TRAF3; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) and similar proteins

    3. XM_028851881.1 → XP_028707714.1  TNF receptor-associated factor 3 isoform X2

      UniProtKB/TrEMBL
      A0A5F7ZEK2, F7HSR4
      Related
      ENSMMUP00000063611.1, ENSMMUT00000083792.1
      Conserved Domains (4) summary
      COG1196
      Location:227 → 408
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd03777
      Location:353 → 538
      MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
      pfam02176
      Location:136 → 192
      zf-TRAF; TRAF-type zinc finger
      cd16640
      Location:51 → 92
      RING-HC_TRAF3; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) and similar proteins

    4. XM_028851883.1 → XP_028707716.1  TNF receptor-associated factor 3 isoform X3

      UniProtKB/TrEMBL
      A0A5F7ZM71, F7HSQ0
      Related
      ENSMMUP00000065717.1, ENSMMUT00000091323.1
      Conserved Domains (4) summary
      COG1196
      Location:214 → 377
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd03777
      Location:322 → 507
      MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
      pfam02176
      Location:136 → 192
      zf-TRAF; TRAF-type zinc finger
      cd16640
      Location:51 → 92
      RING-HC_TRAF3; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) and similar proteins

    5. XM_028851879.1 → XP_028707712.1  TNF receptor-associated factor 3 isoform X1

      UniProtKB/TrEMBL
      A0A1D5RF63, H9FZ66
      Conserved Domains (4) summary
      COG1196
      Location:252 → 433
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd03777
      Location:378 → 563
      MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
      pfam02176
      Location:136 → 192
      zf-TRAF; TRAF-type zinc finger
      cd16640
      Location:51 → 92
      RING-HC_TRAF3; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) and similar proteins

    6. XM_028851882.1 → XP_028707715.1  TNF receptor-associated factor 3 isoform X2

      UniProtKB/TrEMBL
      A0A5F7ZEK2, F7HSR4
      Related
      ENSMMUP00000015419.4, ENSMMUT00000016459.4
      Conserved Domains (4) summary
      COG1196
      Location:227 → 408
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd03777
      Location:353 → 538
      MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
      pfam02176
      Location:136 → 192
      zf-TRAF; TRAF-type zinc finger
      cd16640
      Location:51 → 92
      RING-HC_TRAF3; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) and similar proteins

    7. XM_015144530.2 → XP_015000016.1  TNF receptor-associated factor 3 isoform X1

      UniProtKB/TrEMBL
      A0A1D5RF63, H9FZ66
      Conserved Domains (4) summary
      COG1196
      Location:252 → 433
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd03777
      Location:378 → 563
      MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
      pfam02176
      Location:136 → 192
      zf-TRAF; TRAF-type zinc finger
      cd16640
      Location:51 → 92
      RING-HC_TRAF3; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) and similar proteins

    8. XM_028851878.1 → XP_028707711.1  TNF receptor-associated factor 3 isoform X1

      UniProtKB/TrEMBL
      A0A1D5RF63, H9FZ66
      Conserved Domains (4) summary
      COG1196
      Location:252 → 433
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd03777
      Location:378 → 563
      MATH_TRAF3; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF3 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
      pfam02176
      Location:136 → 192
      zf-TRAF; TRAF-type zinc finger
      cd16640
      Location:51 → 92
      RING-HC_TRAF3; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) and similar proteins
    Nucleotide Protein
    Heading Accession and Version

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