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    NPC1L1 NPC1 like intracellular cholesterol transporter 1 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 699235, updated on 17-Aug-2024

    Summary

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    Official Symbol
    NPC1L1provided by VGNC
    Official Full Name
    NPC1 like intracellular cholesterol transporter 1provided by VGNC
    Primary source
    VGNC:VGNC:75381
    See related
    Ensembl:ENSMMUG00000000782
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See NPC1L1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 3 NC_041756.1 (70672876..70708108)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 3 NC_027895.1 (64242280..64278013)

    Chromosome 3 - NC_041756.1Genomic Context describing neighboring genes Neighboring gene oxoglutarate dehydrogenase Neighboring gene vegetative cell wall protein gp1-like Neighboring gene transmembrane p24 trafficking protein 4 Neighboring gene 60S ribosomal protein L36a-like Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. In vivo responsiveness to ezetimibe correlates with niemann-pick C1 like-1 (NPC1L1) binding affinity: Comparison of multiple species NPC1L1 orthologs. Hawes BE, et al. Mol Pharmacol, 2007 Jan. PMID 17005902
    2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables lipid transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NPC1-like intracellular cholesterol transporter 1
    Names
    NPC1 (Niemann-Pick disease, type C1, gene)-like 1
    Niemann-Pick C1-like 1 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077689.1 → NP_001071157.1  NPC1-like intracellular cholesterol transporter 1 precursor

      See identical proteins and their annotated locations for NP_001071157.1

      Status: PROVISIONAL

      Source sequence(s)
      DQ897677
      UniProtKB/TrEMBL
      A0MJA5, F6RBH5, G7MLD6
      Related
      ENSMMUP00000001055.4, ENSMMUT00000001126.4
      Conserved Domains (3) summary
      TIGR00917
      Location:33 → 1266
      2A060601; Niemann-Pick C type protein family
      pfam12349
      Location:661 → 814
      Sterol-sensing; Sterol-sensing domain of SREBP cleavage-activation
      pfam16414
      Location:31 → 283
      NPC1_N; Niemann-Pick C1 N terminus

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041756.1 Reference Mmul_10 Primary Assembly

      Range
      70672876..70708108
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028844847.1 → XP_028700680.1  NPC1-like intracellular cholesterol transporter 1 isoform X1

      Conserved Domains (1) summary
      TIGR00917
      Location:33 → 722
      2A060601; Niemann-Pick C type protein family
    Nucleotide Protein
    Heading Accession and Version

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