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    Bicral BRD4 interacting chromatin remodeling complex associated protein like [ Mus musculus (house mouse) ]

    Gene ID: 210982, updated on 23-Dec-2024

    Summary

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    Official Symbol
    Bicralprovided by MGI
    Official Full Name
    BRD4 interacting chromatin remodeling complex associated protein likeprovided by MGI
    Primary source
    MGI:MGI:2673855
    See related
    Ensembl:ENSMUSG00000036568 AllianceGenome:MGI:2673855
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gltscr1l; mKIAA0240
    Summary
    Predicted to be involved in positive regulation of DNA-templated transcription. Part of SWI/SNF complex. Is expressed in several structures, including genitourinary system; heart; nervous system; respiratory system; and sensory organ. Orthologous to human BICRAL (BICRA like chromatin remodeling complex associated protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in frontal lobe adult (RPKM 3.2), cerebellum adult (RPKM 3.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Bicral in Genome Data Viewer
    Location:
    17 C; 17 22.9 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (47109046..47201329, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (46798116..46890442, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7539 Neighboring gene STARR-positive B cell enhancer ABC_E7540 Neighboring gene ribosomal protein L7-like 1 Neighboring gene peroxisomal biogenesis factor 39 Neighboring gene STARR-seq mESC enhancer starr_42679 Neighboring gene STARR-seq mESC enhancer starr_42682 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:46965989-46966172 Neighboring gene STARR-seq mESC enhancer starr_42687 Neighboring gene STARR-seq mESC enhancer starr_42689 Neighboring gene STARR-positive B cell enhancer ABC_E170 Neighboring gene STARR-seq mESC enhancer starr_42692 Neighboring gene tubulin-specific chaperone C Neighboring gene peripherin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A non-canonical BRD9-containing BAF chromatin remodeling complex regulates naive pluripotency in mouse embryonic stem cells. Gatchalian J, et al. Nat Commun, 2018 Dec 3. PMID 30510198, Free PMC Article
    2. Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes. Alpsoy A, et al. J Biol Chem, 2018 Mar 16. PMID 29374058, Free PMC Article
    3. Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2002 Oct 31. PMID 12465718
    4. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812
    5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1)  1 citation

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0240

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in chromatin remodeling NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of cell differentiation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell population proliferation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of stem cell population maintenance NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of GBAF complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of SWI/SNF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SWI/SNF complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SWI/SNF complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromatin NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    BRD4-interacting chromatin-remodeling complex-associated protein-like
    Names
    GLTSCR1-like
    GLTSCR1-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100452.2 → NP_001093922.1  BRD4-interacting chromatin-remodeling complex-associated protein-like

      See identical proteins and their annotated locations for NP_001093922.1

      Status: VALIDATED

      Source sequence(s)
      CT030702
      Consensus CDS
      CCDS50126.1
      UniProtKB/Swiss-Prot
      Q8CHH5
      UniProtKB/TrEMBL
      B2RX81
      Related
      ENSMUSP00000156590.2, ENSMUST00000233537.2
      Conserved Domains (2) summary
      PRK07003
      Location:492 → 693
      PRK07003; DNA polymerase III subunit gamma/tau
      pfam15249
      Location:708 → 808
      GLTSCR1; Conserved region of unknown function on GLTSCR protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      47109046..47201329 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160440.1 → XP_036016333.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X1

      UniProtKB/Swiss-Prot
      Q8CHH5
      UniProtKB/TrEMBL
      B2RX81
      Conserved Domains (2) summary
      PRK07003
      Location:492 → 693
      PRK07003; DNA polymerase III subunit gamma/tau
      pfam15249
      Location:708 → 808
      GLTSCR1; Conserved region of unknown function on GLTSCR protein

    2. XM_006523976.4 → XP_006524039.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X1

      See identical proteins and their annotated locations for XP_006524039.1

      UniProtKB/Swiss-Prot
      Q8CHH5
      UniProtKB/TrEMBL
      B2RX81
      Conserved Domains (2) summary
      PRK07003
      Location:492 → 693
      PRK07003; DNA polymerase III subunit gamma/tau
      pfam15249
      Location:708 → 808
      GLTSCR1; Conserved region of unknown function on GLTSCR protein

    3. XM_036160439.1 → XP_036016332.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X1

      UniProtKB/Swiss-Prot
      Q8CHH5
      UniProtKB/TrEMBL
      B2RX81
      Conserved Domains (2) summary
      PRK07003
      Location:492 → 693
      PRK07003; DNA polymerase III subunit gamma/tau
      pfam15249
      Location:708 → 808
      GLTSCR1; Conserved region of unknown function on GLTSCR protein

    4. XM_036160438.1 → XP_036016331.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X1

      UniProtKB/Swiss-Prot
      Q8CHH5
      UniProtKB/TrEMBL
      B2RX81
      Conserved Domains (2) summary
      PRK07003
      Location:492 → 693
      PRK07003; DNA polymerase III subunit gamma/tau
      pfam15249
      Location:708 → 808
      GLTSCR1; Conserved region of unknown function on GLTSCR protein

    5. XM_036160437.1 → XP_036016330.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X1

      UniProtKB/Swiss-Prot
      Q8CHH5
      UniProtKB/TrEMBL
      B2RX81
      Conserved Domains (2) summary
      PRK07003
      Location:492 → 693
      PRK07003; DNA polymerase III subunit gamma/tau
      pfam15249
      Location:708 → 808
      GLTSCR1; Conserved region of unknown function on GLTSCR protein

    6. XM_011246345.4 → XP_011244647.2  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X1

      UniProtKB/Swiss-Prot
      Q8CHH5
      UniProtKB/TrEMBL
      B2RX81
      Conserved Domains (2) summary
      PRK07003
      Location:492 → 693
      PRK07003; DNA polymerase III subunit gamma/tau
      pfam15249
      Location:708 → 808
      GLTSCR1; Conserved region of unknown function on GLTSCR protein

    7. XM_017317377.2 → XP_017172866.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X1

      UniProtKB/Swiss-Prot
      Q8CHH5
      UniProtKB/TrEMBL
      B2RX81
      Conserved Domains (2) summary
      PRK07003
      Location:492 → 693
      PRK07003; DNA polymerase III subunit gamma/tau
      pfam15249
      Location:708 → 808
      GLTSCR1; Conserved region of unknown function on GLTSCR protein

    8. XM_036160441.1 → XP_036016334.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X1

      UniProtKB/Swiss-Prot
      Q8CHH5
      UniProtKB/TrEMBL
      B2RX81
      Conserved Domains (2) summary
      PRK07003
      Location:492 → 693
      PRK07003; DNA polymerase III subunit gamma/tau
      pfam15249
      Location:708 → 808
      GLTSCR1; Conserved region of unknown function on GLTSCR protein

    9. XM_011246346.4 → XP_011244648.3  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X2

      Conserved Domains (2) summary
      PRK07003
      Location:496 → 697
      PRK07003; DNA polymerase III subunit gamma/tau
      pfam15249
      Location:712 → 812
      GLTSCR1; Conserved region of unknown function on GLTSCR protein

    10. XM_006523974.5 → XP_006524037.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X3

      Conserved Domains (2) summary
      PRK07003
      Location:513 → 714
      PRK07003; DNA polymerase III subunit gamma/tau
      pfam15249
      Location:729 → 829
      GLTSCR1; Conserved region of unknown function on GLTSCR protein

    11. XM_006523981.5 → XP_006524044.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X1

      See identical proteins and their annotated locations for XP_006524044.1

      UniProtKB/Swiss-Prot
      Q8CHH5
      UniProtKB/TrEMBL
      B2RX81
      Conserved Domains (2) summary
      PRK07003
      Location:492 → 693
      PRK07003; DNA polymerase III subunit gamma/tau
      pfam15249
      Location:708 → 808
      GLTSCR1; Conserved region of unknown function on GLTSCR protein

    12. XM_036160436.1 → XP_036016329.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X1

      UniProtKB/Swiss-Prot
      Q8CHH5
      UniProtKB/TrEMBL
      B2RX81
      Conserved Domains (2) summary
      PRK07003
      Location:492 → 693
      PRK07003; DNA polymerase III subunit gamma/tau
      pfam15249
      Location:708 → 808
      GLTSCR1; Conserved region of unknown function on GLTSCR protein

    13. XM_036160435.1 → XP_036016328.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X1

      UniProtKB/Swiss-Prot
      Q8CHH5
      UniProtKB/TrEMBL
      B2RX81
      Conserved Domains (2) summary
      PRK07003
      Location:492 → 693
      PRK07003; DNA polymerase III subunit gamma/tau
      pfam15249
      Location:708 → 808
      GLTSCR1; Conserved region of unknown function on GLTSCR protein

    14. XM_006523975.4 → XP_006524038.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X4

      Conserved Domains (2) summary
      PRK07003
      Location:495 → 696
      PRK07003; DNA polymerase III subunit gamma/tau
      pfam15249
      Location:711 → 811
      GLTSCR1; Conserved region of unknown function on GLTSCR protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CHH5.2 GenPept UniProtKB/Swiss-Prot:Q8CHH5

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