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    Sh3bgrl SH3-binding domain glutamic acid-rich protein like [ Mus musculus (house mouse) ]

    Gene ID: 56726, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sh3bgrlprovided by MGI
    Official Full Name
    SH3-binding domain glutamic acid-rich protein likeprovided by MGI
    Primary source
    MGI:MGI:1930849
    See related
    Ensembl:ENSMUSG00000031246 AllianceGenome:MGI:1930849
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1190008F14Rik
    Summary
    Predicted to enable protein-RNA adaptor activity and ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in positive regulation of cytoplasmic translational initiation and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in cerebral cortex and genitourinary system. Orthologous to human SH3BGRL (SH3 domain binding glutamate rich protein like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in bladder adult (RPKM 66.7), CNS E11.5 (RPKM 36.9) and 19 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Sh3bgrl in Genome Data Viewer
    Location:
    X D; X 47.92 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (108139013..108206073)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (109095407..109162467)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 23322 Neighboring gene high-mobility group nucleosome binding domain 5 Neighboring gene predicted gene, 25797 Neighboring gene upstream transcription factor 1 pseudogene Neighboring gene predicted gene, 34464 Neighboring gene predicted gene 6377

    Genomic regions, transcripts, and products

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular_function ND
    No biological Data available
    more info
     
    enables protein-RNA adaptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-RNA adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-like ligase-substrate adaptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin-like ligase-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    adapter Sh3bgrl
    Names
    SH3 domain-binding glutamic acid-rich-like protein
    SH3 domain-binding glutamic acid-rich-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019989.2NP_064373.1  adapter Sh3bgrl

      See identical proteins and their annotated locations for NP_064373.1

      Status: PROVISIONAL

      Source sequence(s)
      BC043055
      Consensus CDS
      CCDS41102.1
      UniProtKB/Swiss-Prot
      A2ALN7, Q3UB57, Q9JJU8
      UniProtKB/TrEMBL
      Q3U9A8
      Related
      ENSMUSP00000033598.9, ENSMUST00000033598.9
      Conserved Domains (1) summary
      cd03030
      Location:297
      GRX_SH3BGR; Glutaredoxin (GRX) family, SH3BGR (SH3 domain binding glutamic acid-rich protein) subfamily; a recently-identified subfamily composed of SH3BGR and similar proteins possessing significant sequence similarity to GRX, but without a redox active CXXC motif. ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      108139013..108206073
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)