Ceacam1 CEA cell adhesion molecule 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ceacam1provided by MGI
Official Full Name: CEA cell adhesion molecule 1provided by MGI
Primary source: MGI:MGI:1347245
See related: Ensembl:ENSMUSG00000074272 AllianceGenome:MGI:1347245
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bgp; Cc1; Hv2; Bgp1; Cea1; Cea7; Hv-2; MHVR; bb-1; C-CAM; CD66a; Cea-1; Cea-7; MHVR1; Mhv-1; mCEA1; mmCGM1; mmCGM2; mmCGM1a
Summary: Enables Toll-like receptor binding activity; granulocyte colony-stimulating factor receptor binding activity; and protein tyrosine kinase binding activity. Involved in several processes, including common myeloid progenitor cell proliferation; granulocyte colony-stimulating factor signaling pathway; and negative regulation of macromolecule metabolic process. Acts upstream of or within several processes, including negative regulation of T cell proliferation; negative regulation of bone resorption; and negative regulation of osteoclast differentiation. Located in ciliary membrane and external side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; extraembryonic component; genitourinary system; and skeleton. Orthologous to several human genes including CEACAM1 (CEA cell adhesion molecule 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in colon adult (RPKM 419.7), large intestine adult (RPKM 308.1) and 3 other tissues See more
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Genomic context

Location:: 7 A3; 7 13.84 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (25161127..25177072, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (25461702..25477647, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of CEACAM1 in hepatocytes causes hepatic fibrosis.
Title: Loss of CEACAM1 in hepatocytes causes hepatic fibrosis.
Conditional deletion of CEACAM1 in hepatic stellate cells causes their activation.
Title: Conditional deletion of CEACAM1 in hepatic stellate cells causes their activation.
Alternative splicing of CEACAM1 by hypoxia-inducible factor-1alpha enhances tolerance to hepatic ischemia in mice and humans.
Title: Alternative splicing of CEACAM1 by hypoxia-inducible factor-1α enhances tolerance to hepatic ischemia in mice and humans.
Loss of CEACAM1 in endothelial cells causes hepatic fibrosis.
Title: Loss of CEACAM1 in endothelial cells causes hepatic fibrosis.
Neutrophil CEACAM1 determines susceptibility to NETosis by regulating the S1PR2/S1PR3 axis in liver transplantation.
Title: Neutrophil CEACAM1 determines susceptibility to NETosis by regulating the S1PR2/S1PR3 axis in liver transplantation.
Mice Lacking PECAM-1 and Ceacam1 Have Enhanced Platelet Secretion and Thrombus Growth: Novel Link with PAR4.
Title: Mice Lacking PECAM-1 and Ceacam1 Have Enhanced Platelet Secretion and Thrombus Growth: Novel Link with PAR4.
Human CEACAM1-LF regulates lipid storage in HepG2 cells via fatty acid transporter CD36.
Title: Human CEACAM1-LF regulates lipid storage in HepG2 cells via fatty acid transporter CD36.
Insulin Sensitivity Is Retained in Mice with Endothelial Loss of Carcinoembryonic Antigen Cell Adhesion Molecule 1.
Title: Insulin Sensitivity Is Retained in Mice with Endothelial Loss of Carcinoembryonic Antigen Cell Adhesion Molecule 1.
Regulation of hepatic fibrosis by carcinoembryonic antigen-related cell adhesion molecule 1.
Title: Regulation of hepatic fibrosis by carcinoembryonic antigen-related cell adhesion molecule 1.
CEACAM1 regulates CD8(+) T cell immunity and protects from severe pathology during Citrobacter rodentium induced colitis.
Title: CEACAM1 regulates CD8(+) T cell immunity and protects from severe pathology during Citrobacter rodentium induced colitis.

Submit: New GeneRIF Correction See all GeneRIFs (87)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Spontaneous (2) 1 citation
Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D7Mit23 (e-PCR), detects polymorphism
- UniSTS:131123

AI267129 (e-PCR)
- UniSTS:159610

D7Dcr2 (e-PCR), detects polymorphism
- UniSTS:507776

Ceacam1 (e-PCR), detects polymorphism
- UniSTS:275682

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GPI anchor binding	ISO Inferred from Sequence Orthology more info
enables Toll-like receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables actin binding	ISO Inferred from Sequence Orthology more info
enables bile acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables bile acid transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	ISS Inferred from Sequence or Structural Similarity more info
enables filamin binding	ISO Inferred from Sequence Orthology more info
enables granulocyte colony-stimulating factor receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	ISO Inferred from Sequence Orthology more info
enables protein dimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine kinase binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables virus receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in bile acid and bile salt transport	ISO Inferred from Sequence Orthology more info
involved_in bile acid and bile salt transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion via plasma-membrane adhesion molecules	ISO Inferred from Sequence Orthology more info
involved_in cell-cell junction organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to insulin stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in common myeloid progenitor cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in granulocyte colony-stimulating factor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	ISO Inferred from Sequence Orthology more info
involved_in insulin catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insulin catabolic process	ISO Inferred from Sequence Orthology more info
involved_in insulin catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in insulin receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in insulin receptor internalization	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of T cell mediated cytotoxicity	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of T cell receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of bone resorption	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cytotoxic T cell degranulation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fatty acid biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of granulocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of hepatocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of hepatocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of hepatocyte proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of interleukin-1 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of lipid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of osteoclast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of platelet aggregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of vascular permeability	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of homophilic cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vasculogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of blood vessel remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of endothelial cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of endothelial cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of epidermal growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of epidermal growth factor receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of homophilic cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in regulation of homophilic cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of immune system process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in symbiont entry into host cell	IEA Inferred from Electronic Annotation more info
involved_in wound healing, spreading of cells	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of T cell receptor complex	ISO Inferred from Sequence Orthology more info
part_of T cell receptor complex	ISS Inferred from Sequence or Structural Similarity more info
located_in adherens junction	ISO Inferred from Sequence Orthology more info
located_in adherens junction	ISS Inferred from Sequence or Structural Similarity more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in basal plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basal plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cell junction	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISS Inferred from Sequence or Structural Similarity more info
located_in ciliary membrane	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in lateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in lateral plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	ISO Inferred from Sequence Orthology more info	PubMed
located_in microvillus membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of transforming growth factor beta ligand-receptor complex	ISO Inferred from Sequence Orthology more info
located_in transport vesicle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cell adhesion molecule CEACAM1; carcinoembryonic antigen-related cell adhesion molecule 1

Names: BGP-1; CEA-related cell adhesion molecule 1; MHV-R; biliary glycoprotein 1; biliary glycoprotein D; carcinoembryonic antigen 1; carcinoembryonic antigen 7; hepatitis virus (MHV-4) susceptibility; hepatitis virus receptor; murine hepatitis virus receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039185.1 → NP_001034274.1 cell adhesion molecule CEACAM1 isoform 1 precursor

See identical proteins and their annotated locations for NP_001034274.1

Status: VALIDATED

Source sequence(s)

AAHY01060000, AB236328, M77196

Consensus CDS

CCDS20984.1

UniProtKB/Swiss-Prot

P31809, Q61350, Q61353

UniProtKB/TrEMBL

Q925P3

Related

ENSMUSP00000096266.2, ENSMUST00000098669.8

Conserved Domains (6) summary

cd05774
Location:36 → 140

Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

smart00408
Location:340 → 401

IGc2; Immunoglobulin C-2 Type

cd12841
Location:416 → 452

TM_EphA1; Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase

smart00410
Location:246 → 320

IG_like; Immunoglobulin like

pfam13895
Location:242 → 320

Ig_2; Immunoglobulin domain

cl11960
Location:146 → 235

Ig; Immunoglobulin domain
NM_001039186.1 → NP_001034275.1 cell adhesion molecule CEACAM1 isoform 2 precursor

See identical proteins and their annotated locations for NP_001034275.1

Status: VALIDATED

Source sequence(s)

AAHY01060000, M77196

Consensus CDS

CCDS39839.1

UniProtKB/TrEMBL

Q61351

Related

ENSMUSP00000096263.3, ENSMUST00000098666.9

Conserved Domains (6) summary

cd05774
Location:36 → 140

Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

smart00408
Location:340 → 401

IGc2; Immunoglobulin C-2 Type

cd12841
Location:416 → 452

TM_EphA1; Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase

smart00410
Location:246 → 320

IG_like; Immunoglobulin like

pfam13895
Location:242 → 320

Ig_2; Immunoglobulin domain

cl11960
Location:146 → 235

Ig; Immunoglobulin domain
NM_001039187.1 → NP_001034276.1 cell adhesion molecule CEACAM1 isoform 4 precursor

See identical proteins and their annotated locations for NP_001034276.1

Status: VALIDATED

Source sequence(s)

AAHY01060000, AB236329

Consensus CDS

CCDS85244.1

UniProtKB/TrEMBL

Q3LFS6, Q3LFS8

Related

ENSMUSP00000146066.2, ENSMUST00000206687.2

Conserved Domains (4) summary

cd05774
Location:36 → 140

Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

cd12841
Location:236 → 272

TM_EphA1; Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase

smart00410
Location:153 → 226

IG_like; Immunoglobulin like

cl11960
Location:142 → 232

Ig; Immunoglobulin domain
NM_011926.2 → NP_036056.2 cell adhesion molecule CEACAM1 isoform 3 precursor

See identical proteins and their annotated locations for NP_036056.2

Status: VALIDATED

Source sequence(s)

AAHY01060000, AB236328

Consensus CDS

CCDS20985.1

UniProtKB/TrEMBL

Q3LFS9, Q61354

Related

ENSMUSP00000096265.2, ENSMUST00000098668.3

Conserved Domains (4) summary

cd05774
Location:36 → 140

Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

smart00408
Location:160 → 221

IGc2; Immunoglobulin C-2 Type

cd12841
Location:236 → 272

TM_EphA1; Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase

smart00410
Location:153 → 226

IG_like; Immunoglobulin like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

25161127..25177072 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030242604.1 → XP_030098464.1 carcinoembryonic antigen-related cell adhesion molecule 1 isoform X1

UniProtKB/TrEMBL

Q3LFS5, Q61351

Related

ENSMUSP00000145590.2, ENSMUST00000206676.2

Conserved Domains (4) summary

smart00408
Location:340 → 401

IGc2; Immunoglobulin C-2 Type

cd05774
Location:36 → 140

Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

pfam13895
Location:242 → 315

Ig_2; Immunoglobulin domain

cl11960
Location:146 → 235

Ig; Immunoglobulin domain