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    Dctn1 dynactin 1 [ Mus musculus (house mouse) ]

    Gene ID: 13191, updated on 4-Jan-2025

    Summary

    Official Symbol
    Dctn1provided by MGI
    Official Full Name
    dynactin 1provided by MGI
    Primary source
    MGI:MGI:107745
    See related
    Ensembl:ENSMUSG00000031865 AllianceGenome:MGI:107745
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p150; Glued; DP-150; DAP-150; p150-glued; p150<glued>
    Summary
    Enables microtubule binding activity. Acts upstream of or within melanosome transport. Located in cell leading edge and microtubule cytoskeleton. Part of protein-containing complex. Is expressed in brain; cerebral cortex ventricular layer; cortical plate; embryo; and head. Human ortholog(s) of this gene implicated in Perry syndrome; amyotrophic lateral sclerosis type 1; and autosomal dominant distal hereditary motor neuronopathy 14. Orthologous to human DCTN1 (dynactin subunit 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 36.9), frontal lobe adult (RPKM 32.3) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Dctn1 in Genome Data Viewer
    Location:
    6 C3; 6 35.94 cM
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (83142702..83177103)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (83165909..83200118)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700003E16 gene Neighboring gene STARR-positive B cell enhancer ABC_E6447 Neighboring gene WD repeat domain 54 Neighboring gene STARR-seq mESC enhancer starr_16458 Neighboring gene predicted gene 15624 Neighboring gene solute carrier family 4, sodium bicarbonate cotransporter, member 5 Neighboring gene STARR-seq mESC enhancer starr_16459 Neighboring gene STARR-positive B cell enhancer ABC_E4836 Neighboring gene STARR-positive B cell enhancer ABC_E1323 Neighboring gene methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase Neighboring gene STARR-positive B cell enhancer ABC_E6448

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding  
    enables microtubule binding PubMed 
    enables microtubule binding  
    enables molecular adaptor activity  
    enables protein binding PubMed 
    enables protein kinase binding  
    enables protein kinase binding  
    enables tubulin binding  
    Items 1 - 25 of 38
    Process Evidence Code Pubs
    involved_in cell division  
    involved_in centriole-centriole cohesion  
    involved_in centriole-centriole cohesion  
    involved_in cytoplasmic microtubule organization  
    involved_in establishment of mitotic spindle orientation  
    involved_in establishment of mitotic spindle orientation  
    involved_in establishment of mitotic spindle orientation  
    acts_upstream_of_or_within melanosome transport PubMed 
    involved_in microtubule anchoring at centrosome  
    involved_in microtubule anchoring at centrosome  
    involved_in motor behavior  
    involved_in motor behavior  
    involved_in neuromuscular junction development  
    involved_in neuromuscular junction development  
    involved_in neuromuscular process  
    involved_in neuromuscular process  
    involved_in neuron cellular homeostasis  
    involved_in neuron cellular homeostasis  
    involved_in neuron projection maintenance  
    involved_in neuron projection maintenance  
    involved_in non-motile cilium assembly  
    involved_in non-motile cilium assembly  
    involved_in nuclear membrane disassembly  
    involved_in nuclear membrane disassembly  
    involved_in nuclear migration  
    involved_in positive regulation of intracellular protein transport  
    involved_in positive regulation of microtubule nucleation  
    involved_in positive regulation of microtubule nucleation  
    involved_in positive regulation of microtubule polymerization  
    involved_in positive regulation of microtubule polymerization  
    involved_in positive regulation of neuromuscular junction development  
    involved_in positive regulation of neuromuscular junction development  
    involved_in regulation of mitotic spindle organization  
    involved_in regulation of mitotic spindle organization  
    involved_in retrograde transport, endosome to Golgi  
    involved_in retrograde transport, endosome to Golgi  
    involved_in ventral spinal cord development  
    involved_in ventral spinal cord development  
    Items 1 - 25 of 38
    Items 1 - 20 of 44
    Component Evidence Code Pubs
    is_active_in axon  
    colocalizes_with cell cortex  
    located_in cell cortex  
    located_in cell cortex  
    located_in cell cortex region  
    located_in cell cortex region  
    located_in cell leading edge PubMed 
    part_of centriolar subdistal appendage  
    located_in centriole PubMed 
    located_in centriole  
    located_in centrosome  
    located_in centrosome  
    located_in ciliary basal body PubMed 
    located_in cytoplasm  
    part_of cytoplasmic dynein complex  
    located_in cytosol  
    part_of dynein complex  
    located_in intercellular bridge  
    located_in intercellular bridge  
    is_active_in kinetochore  
    located_in kinetochore  
    located_in kinetochore  
    located_in microtubule  
    part_of microtubule associated complex  
    part_of microtubule associated complex  
    located_in microtubule cytoskeleton  
    located_in microtubule plus-end PubMed 
    located_in microtubule plus-end  
    located_in mitotic spindle  
    located_in mitotic spindle  
    located_in neuron projection  
    located_in neuron projection  
    located_in neuronal cell body  
    located_in neuronal cell body  
    located_in nuclear envelope  
    located_in nuclear envelope  
    part_of protein-containing complex PubMed 
    part_of retromer complex  
    part_of retromer complex  
    located_in spindle  
    located_in spindle  
    is_active_in spindle pole  
    located_in spindle pole PubMed 
    located_in spindle pole  
    Items 1 - 20 of 44

    General protein information

    Preferred Names
    dynactin subunit 1
    Names
    150 kDa dynein-associated polypeptide
    dynactin 1, retrograde axonal transport

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001198866.2NP_001185795.1  dynactin subunit 1 isoform 2

      See identical proteins and their annotated locations for NP_001185795.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an in-frame downstream start codon, compared to variant 1. Variant 2 encodes a protein (isoform 2) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC160400
      Consensus CDS
      CCDS57432.1
      UniProtKB/TrEMBL
      E9Q3M3, Q6NZM3
      Related
      ENSMUSP00000109546.2, ENSMUST00000113913.8
      Conserved Domains (5) summary
      TIGR02168
      Location:203523
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:8891030
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam05109
      Location:84197
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam01302
      Location:1277
      CAP_GLY; CAP-Gly domain
      pfam12455
      Location:510788
      Dynactin; Dynein associated protein
    2. NM_001198867.2NP_001185796.1  dynactin subunit 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR,lacks multiple exons in the coding region, and uses an in-frame downstream start codon, compared to variant 1. Variant 3 encodes a protein (isoform 2) with a shorter N-terminus, compared to isoform 1. Variants 3 and 9 both encode the same isoform (3).
      Source sequence(s)
      AC160400
      Consensus CDS
      CCDS57433.1
      UniProtKB/TrEMBL
      E9Q586, Q3T9V8
      Related
      ENSMUSP00000076623.6, ENSMUST00000077407.12
      Conserved Domains (3) summary
      TIGR02168
      Location:183503
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam01302
      Location:1277
      CAP_GLY; CAP-Gly domain
      pfam12455
      Location:490768
      Dynactin; Dynein associated protein
    3. NM_001347310.2NP_001334239.1  dynactin subunit 1 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks multiple exons in the coding region, and uses a novel start codon, compared to variant 1. Variant 4 encodes a protein (isoform 4) with a distinct and shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC160400
      UniProtKB/TrEMBL
      Q6NZM3
    4. NM_001409578.1NP_001396507.1  dynactin subunit 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC160400
      UniProtKB/TrEMBL
      Q6NZM3
    5. NM_001409579.1NP_001396508.1  dynactin subunit 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC160400
      UniProtKB/TrEMBL
      Q3T9V8
    6. NM_001409580.1NP_001396509.1  dynactin subunit 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC160400
      UniProtKB/TrEMBL
      Q3T9V8
    7. NM_001409581.1NP_001396510.1  dynactin subunit 1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC160400
      UniProtKB/TrEMBL
      D3YX34, Q3T9V8
      Related
      ENSMUSP00000109540.2, ENSMUST00000113907.2
    8. NM_001409582.1NP_001396511.1  dynactin subunit 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC160400
      UniProtKB/TrEMBL
      E9Q586, Q3T9V8
    9. NM_007835.3NP_031861.2  dynactin subunit 1 isoform 1

      See identical proteins and their annotated locations for NP_031861.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC160400
      Consensus CDS
      CCDS39532.1
      UniProtKB/Swiss-Prot
      E9QLJ1, O08788, Q3TZG7
      UniProtKB/TrEMBL
      Q6NZM3
      Related
      ENSMUSP00000109552.4, ENSMUST00000113919.10
      Conserved Domains (5) summary
      pfam01302
      Location:3094
      CAP_GLY; CAP-Gly domain
      pfam08172
      Location:314455
      CASP_C; CASP C terminal
      pfam12455
      Location:525805
      Dynactin; Dynein associated protein
      pfam14915
      Location:227547
      CCDC144C; CCDC144C protein coiled-coil region
      cl23943
      Location:246342
      PCRF; PCRF domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      83142702..83177103
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505493.3XP_006505556.1  dynactin subunit 1 isoform X12

      See identical proteins and their annotated locations for XP_006505556.1

      UniProtKB/TrEMBL
      Q3T9V8
      Conserved Domains (3) summary
      TIGR02168
      Location:183503
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam01302
      Location:1277
      CAP_GLY; CAP-Gly domain
      pfam12455
      Location:490768
      Dynactin; Dynein associated protein
    2. XM_006505490.3XP_006505553.1  dynactin subunit 1 isoform X8

      UniProtKB/TrEMBL
      Q6NZM3
      Conserved Domains (4) summary
      TIGR02168
      Location:197517
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam05109
      Location:64204
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam01302
      Location:1277
      CAP_GLY; CAP-Gly domain
      pfam12455
      Location:504782
      Dynactin; Dynein associated protein
    3. XM_006505492.3XP_006505555.1  dynactin subunit 1 isoform X10

      UniProtKB/TrEMBL
      Q6NZM3
      Conserved Domains (4) summary
      TIGR02168
      Location:190510
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam05109
      Location:64197
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam01302
      Location:1277
      CAP_GLY; CAP-Gly domain
      pfam12455
      Location:497775
      Dynactin; Dynein associated protein
    4. XM_030255135.2XP_030110995.1  dynactin subunit 1 isoform X4

      UniProtKB/TrEMBL
      E9Q3M3, Q6NZM3
      Conserved Domains (5) summary
      TIGR02168
      Location:203523
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:8891030
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam05109
      Location:84197
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam01302
      Location:1277
      CAP_GLY; CAP-Gly domain
      pfam12455
      Location:510788
      Dynactin; Dynein associated protein
    5. XM_006505494.2XP_006505557.1  dynactin subunit 1 isoform X12

      See identical proteins and their annotated locations for XP_006505557.1

      UniProtKB/TrEMBL
      Q3T9V8
      Conserved Domains (3) summary
      TIGR02168
      Location:183503
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam01302
      Location:1277
      CAP_GLY; CAP-Gly domain
      pfam12455
      Location:490768
      Dynactin; Dynein associated protein
    6. XM_036165800.1XP_036021693.1  dynactin subunit 1 isoform X4

      UniProtKB/TrEMBL
      E9Q3M3, Q6NZM3
      Conserved Domains (5) summary
      TIGR02168
      Location:203523
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:8891030
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam05109
      Location:84197
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam01302
      Location:1277
      CAP_GLY; CAP-Gly domain
      pfam12455
      Location:510788
      Dynactin; Dynein associated protein
    7. XM_006505485.2XP_006505548.1  dynactin subunit 1 isoform X1

      UniProtKB/TrEMBL
      Q6NZM3
      Related
      ENSMUSP00000109551.2, ENSMUST00000113918.8
      Conserved Domains (4) summary
      TIGR02168
      Location:220540
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam05109
      Location:101214
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam01302
      Location:2994
      CAP_GLY; CAP-Gly domain
      pfam12455
      Location:527805
      Dynactin; Dynein associated protein
    8. XM_006505486.4XP_006505549.1  dynactin subunit 1 isoform X2

      UniProtKB/TrEMBL
      Q6NZM3
      Conserved Domains (4) summary
      TIGR02168
      Location:214534
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam05109
      Location:81221
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam01302
      Location:2994
      CAP_GLY; CAP-Gly domain
      pfam12455
      Location:521799
      Dynactin; Dynein associated protein
    9. XM_006505487.3XP_006505550.1  dynactin subunit 1 isoform X3

      UniProtKB/TrEMBL
      Q6NZM3
      Conserved Domains (4) summary
      TIGR02168
      Location:207527
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam05109
      Location:81214
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam01302
      Location:2994
      CAP_GLY; CAP-Gly domain
      pfam12455
      Location:514792
      Dynactin; Dynein associated protein
    10. XM_017321379.2XP_017176868.1  dynactin subunit 1 isoform X5

      UniProtKB/TrEMBL
      Q3T9V8
      Conserved Domains (4) summary
      TIGR02168
      Location:207527
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam05109
      Location:81214
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam01302
      Location:2994
      CAP_GLY; CAP-Gly domain
      pfam12455
      Location:514792
      Dynactin; Dynein associated protein
    11. XM_006505489.3XP_006505552.1  dynactin subunit 1 isoform X6

      UniProtKB/TrEMBL
      Q3T9V8
      Conserved Domains (3) summary
      TIGR02168
      Location:200520
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam01302
      Location:2994
      CAP_GLY; CAP-Gly domain
      pfam12455
      Location:507785
      Dynactin; Dynein associated protein
    12. XM_006505491.4XP_006505554.1  dynactin subunit 1 isoform X9

      UniProtKB/TrEMBL
      Q3T9V8
      Conserved Domains (3) summary
      TIGR02168
      Location:200520
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam01302
      Location:2994
      CAP_GLY; CAP-Gly domain
      pfam12455
      Location:507785
      Dynactin; Dynein associated protein
    13. XM_006505496.5XP_006505559.1  dynactin subunit 1 isoform X15

      UniProtKB/TrEMBL
      Q6NZM3
      Conserved Domains (4) summary
      TIGR02168
      Location:220540
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam05109
      Location:101214
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam01302
      Location:2994
      CAP_GLY; CAP-Gly domain
      pfam12455
      Location:527805
      Dynactin; Dynein associated protein
    14. XM_006505488.3XP_006505551.1  dynactin subunit 1 isoform X4

      See identical proteins and their annotated locations for XP_006505551.1

      UniProtKB/TrEMBL
      E9Q3M3, Q6NZM3
      Conserved Domains (5) summary
      TIGR02168
      Location:203523
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:8891030
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam05109
      Location:84197
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam01302
      Location:1277
      CAP_GLY; CAP-Gly domain
      pfam12455
      Location:510788
      Dynactin; Dynein associated protein
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