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    Vmn2r65 vomeronasal 2, receptor 65 [ Mus musculus (house mouse) ]

    Gene ID: 100009609, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Vmn2r65provided by MGI
    Official Full Name
    vomeronasal 2, receptor 65provided by MGI
    Primary source
    MGI:MGI:3642776
    See related
    Ensembl:ENSMUSG00000066372 AllianceGenome:MGI:3642776
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    V2ro
    Summary
    Enables G protein-coupled olfactory receptor activity. Acts upstream of or within neuron differentiation. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See Vmn2r65 in Genome Data Viewer
    Location:
    7 D3; 7 48.38 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (84589377..84613217, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (84940169..84964009, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 5 subfamily AE member 1 Neighboring gene ubiquitin specific peptidase 46 pseudogene Neighboring gene predicted gene, 17985 Neighboring gene STARR-seq mESC enhancer starr_19444 Neighboring gene vomeronasal 2, receptor 66 Neighboring gene vomeronasal 2, receptor, pseudogene 64

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Multisensory Logic of Infant-Directed Aggression by Males. Isogai Y, et al. Cell, 2018 Dec 13. PMID 30550786, Free PMC Article
    2. Sex-specific peptides from exocrine glands stimulate mouse vomeronasal sensory neurons. Kimoto H, et al. Nature, 2005 Oct 6. PMID 16208374
    3. Subpopulations of vomeronasal sensory neurons with coordinated coexpression of type 2 vomeronasal receptor genes are differentially dependent on Vmn2r1. Akiyoshi S, et al. Eur J Neurosci, 2018 Apr. PMID 29465786, Free PMC Article
    4. Majority of cerebrospinal fluid-contacting neurons in the spinal cord of C57Bl/6N mice is present in ectopic position unlike in other studied experimental mice strains and mammalian species. Tonelli Gombalová Z, et al. J Comp Neurol, 2020 Oct 15. PMID 32212159
    5. V2R gene families degenerated in primates, dog and cow, but expanded in opossum. Young JM, et al. Trends Genet, 2007 May. PMID 17382427

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled olfactory receptor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within neuron differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    vomeronasal 2, receptor 65
    Names
    vomeronasal 2 receptor o
    vomeronasal receptor Vmn2r65

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105180.1 → NP_001098650.1  vomeronasal 2, receptor 65 precursor

      See identical proteins and their annotated locations for NP_001098650.1

      Status: PROVISIONAL

      Source sequence(s)
      AC163494
      Consensus CDS
      CCDS52288.1
      UniProtKB/TrEMBL
      G3X931
      Related
      ENSMUSP00000036551.9, ENSMUST00000044583.10
      Conserved Domains (4) summary
      cd06365
      Location:36 → 492
      PBP1_Pheromone_receptor; Ligand-binding domain of the V2R phermone receptor, a member of the family C receptors within the G-protein coupled receptor superfamily
      pfam00003
      Location:587 → 820
      7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
      pfam01094
      Location:75 → 435
      ANF_receptor; Receptor family ligand binding region
      pfam07562
      Location:501 → 552
      NCD3G; Nine Cysteines Domain of family 3 GPCR

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      84589377..84613217 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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