U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) [ Mus musculus (house mouse) ]

    Gene ID: 26357, updated on 9-Dec-2024

    Summary

    Official Symbol
    Abcg2provided by MGI
    Official Full Name
    ATP binding cassette subfamily G member 2 (Junior blood group)provided by MGI
    Primary source
    MGI:MGI:1347061
    See related
    Ensembl:ENSMUSG00000029802 AllianceGenome:MGI:1347061
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MXR; ABCP; BCRP; MXR1; ABC15; Bcrp1
    Summary
    The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, the human protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. This protein likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in kidney adult (RPKM 44.7), placenta adult (RPKM 44.0) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Abcg2 in Genome Data Viewer
    Location:
    6 B3; 6 27.82 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (58561476..58669436)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (58584491..58692451)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene vomeronasal 1 receptor, pseudogene 23 Neighboring gene predicted gene, 35077 Neighboring gene predicted gene, 45943 Neighboring gene STARR-seq mESC enhancer starr_16020 Neighboring gene STARR-seq mESC enhancer starr_16022 Neighboring gene STARR-seq mESC enhancer starr_16023 Neighboring gene predicted gene, 38822 Neighboring gene STARR-seq mESC enhancer starr_16024 Neighboring gene STARR-seq mESC enhancer starr_16025 Neighboring gene STARR-seq mESC enhancer starr_16026 Neighboring gene STARR-seq mESC enhancer starr_16027 Neighboring gene hect domain and RLD 3 Neighboring gene nucleosome assembly protein 1-like 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ABC-type xenobiotic transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ATPase-coupled transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATPase-coupled transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables amide transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables biotin transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables cytoskeletal protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables efflux transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables efflux transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables efflux transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables organic anion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables riboflavin transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables riboflavin transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables riboflavin transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables urate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables urate transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables xenobiotic transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in biotin transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in embryonic process involved in female pregnancy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in export across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of intestinal absorption ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in organic anion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in renal urate salt excretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in renal urate salt excretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in riboflavin transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in riboflavin transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transepithelial transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in urate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in urate transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in urate transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in xenobiotic detoxification by transmembrane export across the plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in xenobiotic transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in xenobiotic transport across blood-brain barrier ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in brush border membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in brush border membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in external side of apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane raft ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    broad substrate specificity ATP-binding cassette transporter ABCG2
    Names
    ATP-binding cassette sub-family G member 2
    ATP-binding cassette, sub-family G (WHITE), member 2
    breast cancer resistance protein 1 homolog
    mitoxantrone resistance protein 1
    urate exporter
    NP_001342406.1
    NP_001368854.1
    NP_001368855.1
    NP_001368856.1
    NP_036050.1
    XP_006506213.1
    XP_011239664.1
    XP_030111259.1
    XP_030111260.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355477.2NP_001342406.1  broad substrate specificity ATP-binding cassette transporter ABCG2

      Status: VALIDATED

      Source sequence(s)
      AC121855, AC121859
      Consensus CDS
      CCDS20195.1
      UniProtKB/Swiss-Prot
      Q7TMS5, Q9R004, Q9Z1T0
      UniProtKB/TrEMBL
      A0A0R4J0B6
      Conserved Domains (1) summary
      TIGR00955
      Location:46651
      3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein
    2. NM_001381925.1NP_001368854.1  broad substrate specificity ATP-binding cassette transporter ABCG2

      Status: VALIDATED

      Source sequence(s)
      AC121855, AC121859
      UniProtKB/Swiss-Prot
      Q7TMS5, Q9R004, Q9Z1T0
      UniProtKB/TrEMBL
      A0A0R4J0B6
      Conserved Domains (1) summary
      TIGR00955
      Location:46651
      3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein
    3. NM_001381926.1NP_001368855.1  broad substrate specificity ATP-binding cassette transporter ABCG2

      Status: VALIDATED

      Source sequence(s)
      AC121855, AC121859
      UniProtKB/Swiss-Prot
      Q7TMS5, Q9R004, Q9Z1T0
      UniProtKB/TrEMBL
      A0A0R4J0B6
      Conserved Domains (1) summary
      TIGR00955
      Location:46651
      3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein
    4. NM_001381927.1NP_001368856.1  broad substrate specificity ATP-binding cassette transporter ABCG2

      Status: VALIDATED

      Source sequence(s)
      AC121859
      UniProtKB/Swiss-Prot
      Q7TMS5, Q9R004, Q9Z1T0
      UniProtKB/TrEMBL
      A0A0R4J0B6
      Related
      ENSMUSP00000109933.2, ENSMUST00000114294.8
      Conserved Domains (1) summary
      TIGR00955
      Location:46651
      3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein
    5. NM_011920.3NP_036050.1  broad substrate specificity ATP-binding cassette transporter ABCG2

      See identical proteins and their annotated locations for NP_036050.1

      Status: VALIDATED

      Source sequence(s)
      AC121855, AC121859, AF103875, AI428558, AK087830, CO039662
      Consensus CDS
      CCDS20195.1
      UniProtKB/Swiss-Prot
      Q7TMS5, Q9R004, Q9Z1T0
      UniProtKB/TrEMBL
      A0A0R4J0B6
      Related
      ENSMUSP00000031822.7, ENSMUST00000031822.13
      Conserved Domains (1) summary
      TIGR00955
      Location:46651
      3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      58561476..58669436
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241362.1XP_011239664.1  broad substrate specificity ATP-binding cassette transporter ABCG2 isoform X1

      See identical proteins and their annotated locations for XP_011239664.1

      UniProtKB/Swiss-Prot
      Q7TMS5, Q9R004, Q9Z1T0
      UniProtKB/TrEMBL
      A0A0R4J0B6
      Conserved Domains (1) summary
      TIGR00955
      Location:46651
      3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein
    2. XM_030255399.2XP_030111259.1  broad substrate specificity ATP-binding cassette transporter ABCG2 isoform X1

      UniProtKB/Swiss-Prot
      Q7TMS5, Q9R004, Q9Z1T0
      UniProtKB/TrEMBL
      A0A0R4J0B6
      Conserved Domains (1) summary
      TIGR00955
      Location:46651
      3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein
    3. XM_030255400.1XP_030111260.1  broad substrate specificity ATP-binding cassette transporter ABCG2 isoform X1

      UniProtKB/Swiss-Prot
      Q7TMS5, Q9R004, Q9Z1T0
      UniProtKB/TrEMBL
      A0A0R4J0B6
      Conserved Domains (1) summary
      TIGR00955
      Location:46651
      3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein
    4. XM_006506150.5XP_006506213.1  broad substrate specificity ATP-binding cassette transporter ABCG2 isoform X1

      See identical proteins and their annotated locations for XP_006506213.1

      UniProtKB/Swiss-Prot
      Q7TMS5, Q9R004, Q9Z1T0
      UniProtKB/TrEMBL
      A0A0R4J0B6
      Conserved Domains (1) summary
      TIGR00955
      Location:46651
      3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein