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    Ucn urocortin [ Mus musculus (house mouse) ]

    Gene ID: 22226, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ucnprovided by MGI
    Official Full Name
    urocortinprovided by MGI
    Primary source
    MGI:MGI:1276123
    See related
    Ensembl:ENSMUSG00000038676 AllianceGenome:MGI:1276123
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ucn1; Mpv17
    Summary
    This gene encodes a member of the corticotropin-releasing hormone peptide family that participates in coordinating autonomic, endocrine, and behavioral responses to stress. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional hormone. Mice lacking the encoded protein exhibit a heightened anxiety-like behaviors and a significantly reduced acoustic startle response. [provided by RefSeq, Sep 2016]
    Expression
    Biased expression in heart adult (RPKM 1.5), frontal lobe adult (RPKM 0.4) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Ucn in Genome Data Viewer
    Location:
    5 B1; 5 17.11 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (31295333..31296239, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (31137989..31138895, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C5 gamma Neighboring gene STARR-seq mESC enhancer starr_12766 Neighboring gene tripartite motif-containing 54 Neighboring gene predicted gene 15469 Neighboring gene MpV17 mitochondrial inner membrane protein Neighboring gene general transcription factor IIIC, polypeptide 2, beta Neighboring gene STARR-seq mESC enhancer starr_12767

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    General gene information

    Markers

    Clone Names

    • MGC151325, MGC151327

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables corticotropin-releasing hormone receptor 1 binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables corticotropin-releasing hormone receptor 1 binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables corticotropin-releasing hormone receptor 2 binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables corticotropin-releasing hormone receptor 2 binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone deacetylase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone deacetylase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in aerobic respiration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in aerobic respiration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in associative learning IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in associative learning ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in drinking behavior IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in drinking behavior ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in feeding behavior ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in female pregnancy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in learning or memory ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of appetite IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of appetite ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of blood pressure IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell size IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell size ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of feeding behavior IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of feeding behavior IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of feeding behavior ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of hormone secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of hormone secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron projection development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuropeptide signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA replication IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of behavioral fear response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of behavioral fear response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cAMP-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cAMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of calcium ion import IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of calcium ion import ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cardiac muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cardiac muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell growth IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of collagen biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of collagen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of corticotropin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of corticotropin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-6 production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vascular permeability IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of vascular permeability ISO
    Inferred from Sequence Orthology
    more info
     
    NOT involved_in prepulse inhibition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of synaptic transmission, glutamatergic IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of synaptic transmission, glutamatergic ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to auditory stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to estradiol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to glucocorticoid IEA
    Inferred from Electronic Annotation
    more info
     
    NOT involved_in response to immobilization stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to pain IEA
    Inferred from Electronic Annotation
    more info
     
    NOT involved_in response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sensory perception of sound IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in social behavior IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in social behavior ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in startle response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vasodilation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vasodilation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon terminus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in axon terminus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in varicosity IEA
    Inferred from Electronic Annotation
    more info
     
    located_in varicosity ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001346010.1NP_001332939.1  urocortin preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC109608, BC144891
      Consensus CDS
      CCDS19174.1
      UniProtKB/Swiss-Prot
      O88390, P81615, Q14A76
      Related
      ENSMUSP00000144390.2, ENSMUST00000201184.2
      Conserved Domains (1) summary
      pfam00473
      Location:83120
      CRF; Corticotropin-releasing factor family
    2. NM_021290.2NP_067265.1  urocortin preproprotein

      See identical proteins and their annotated locations for NP_067265.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC109608
      Consensus CDS
      CCDS19174.1
      UniProtKB/Swiss-Prot
      O88390, P81615, Q14A76
      Related
      ENSMUSP00000035321.3, ENSMUST00000043475.7
      Conserved Domains (1) summary
      pfam00473
      Location:83120
      CRF; Corticotropin-releasing factor family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      31295333..31296239 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)