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    Lrrc43 leucine rich repeat containing 43 [ Mus musculus (house mouse) ]

    Gene ID: 381741, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lrrc43provided by MGI
    Official Full Name
    leucine rich repeat containing 43provided by MGI
    Primary source
    MGI:MGI:2685907
    See related
    Ensembl:ENSMUSG00000063409 AllianceGenome:MGI:2685907
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm1061
    Summary
    Predicted to enable dynein complex binding activity. Predicted to be involved in axoneme assembly. Predicted to be active in axoneme. Orthologous to human LRRC43 (leucine rich repeat containing 43). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 53.6) See more
    Orthologs
    human all
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    Genomic context

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    See Lrrc43 in Genome Data Viewer
    Location:
    5 F; 5 63.01 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (123627349..123646268)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (123489287..123508205)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L31, pseudogene 6 Neighboring gene interleukin 31 Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 Neighboring gene diablo, IAP-binding mitochondrial protein Neighboring gene microRNA 7647

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
    2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat-containing protein 43

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033461.3 → NP_001028633.1  leucine-rich repeat-containing protein 43 isoform 1

      See identical proteins and their annotated locations for NP_001028633.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK133051, DV646947
      Consensus CDS
      CCDS19664.1
      UniProtKB/Swiss-Prot
      Q3TIS6, Q3TJS5, Q3V0L5
      UniProtKB/TrEMBL
      B9EKH4
      Related
      ENSMUSP00000091885.4, ENSMUST00000094327.10
      Conserved Domains (2) summary
      COG4886
      Location:154 → 263
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:171 → 194
      LRR_1; leucine-rich repeat [structural motif]

    2. NM_001289821.1 → NP_001276750.1  leucine-rich repeat-containing protein 43 isoform 2

      See identical proteins and their annotated locations for NP_001276750.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AK133051, AK167729, DV646947
      Consensus CDS
      CCDS71662.1
      UniProtKB/TrEMBL
      B9EKH4
      Related
      ENSMUSP00000113933.2, ENSMUST00000121444.2
      Conserved Domains (2) summary
      COG4886
      Location:154 → 263
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:171 → 194
      LRR_1; leucine-rich repeat [structural motif]

    3. NM_001289822.1 → NP_001276751.1  leucine-rich repeat-containing protein 43 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, resulting in a frameshift and an early stop codon, compared to variant 1. It encodes isoform 3, which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK133051, AK167729, DV646947
      Consensus CDS
      CCDS80402.1
      UniProtKB/TrEMBL
      A0A0G2JGK7, B9EKH4
      Related
      ENSMUSP00000143602.2, ENSMUST00000196809.5
      Conserved Domains (2) summary
      COG4886
      Location:154 → 263
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:171 → 194
      LRR_1; leucine-rich repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      123627349..123646268
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030254637.2 → XP_030110497.1  leucine-rich repeat-containing protein 43 isoform X1

      Conserved Domains (2) summary
      COG4886
      Location:154 → 263
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:171 → 194
      LRR_1; leucine-rich repeat [structural motif]

    2. XM_006530400.5 → XP_006530463.1  leucine-rich repeat-containing protein 43 isoform X1

      Conserved Domains (2) summary
      COG4886
      Location:154 → 263
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:171 → 194
      LRR_1; leucine-rich repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3V0L5.1 GenPept UniProtKB/Swiss-Prot:Q3V0L5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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