U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Ptpn3 protein tyrosine phosphatase, non-receptor type 3 [ Mus musculus (house mouse) ]

    Gene ID: 545622, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ptpn3provided by MGI
    Official Full Name
    protein tyrosine phosphatase, non-receptor type 3provided by MGI
    Primary source
    MGI:MGI:105307
    See related
    Ensembl:ENSMUSG00000038764 AllianceGenome:MGI:105307
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PTPCL; PTP-H1; 9530011I20Rik
    Summary
    Predicted to enable several functions, including ATPase binding activity; phosphotyrosine residue binding activity; and sodium channel regulator activity. Predicted to be involved in several processes, including negative regulation of membrane protein ectodomain proteolysis; protein dephosphorylation; and regulation of membrane depolarization during action potential. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm and cytoplasmic side of plasma membrane. Is expressed in several structures, including cranial ganglion; gut; nasal epithelium; submandibular gland primordium; and urinary system. Orthologous to human PTPN3 (protein tyrosine phosphatase non-receptor type 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 7.3), cortex adult (RPKM 5.5) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ptpn3 in Genome Data Viewer
    Location:
    4 B3; 4 31.66 cM
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (57190841..57339036, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (57190841..57339040, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_10320 Neighboring gene predicted gene, 34802 Neighboring gene predicted gene 12530 Neighboring gene STARR-seq mESC enhancer starr_10325 Neighboring gene STARR-seq mESC enhancer starr_10327 Neighboring gene predicted gene 12536 Neighboring gene RIKEN cDNA 1700042G15 gene Neighboring gene STARR-seq mESC enhancer starr_10329 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cytoskeletal protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXY142 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphotyrosine residue binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphotyrosine residue binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein tyrosine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein tyrosine phosphatase activity, metal-dependent IEA
    Inferred from Electronic Annotation
    more info
     
    enables sodium channel regulator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables sodium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasmic side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasmic side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    tyrosine-protein phosphatase non-receptor type 3
    Names
    protein-tyrosine phosphatase H1
    NP_001371044.1
    NP_035337.2
    XP_006538160.1
    XP_006538162.1
    XP_006538163.1
    XP_006538164.1
    XP_036020143.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001384115.1NP_001371044.1  tyrosine-protein phosphatase non-receptor type 3

      Status: VALIDATED

      Source sequence(s)
      AL805921
      UniProtKB/Swiss-Prot
      A2ALK8
      Conserved Domains (4) summary
      smart00295
      Location:31222
      B41; Band 4.1 homologues
      cd00992
      Location:508595
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13189
      Location:216309
      FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
      cd14600
      Location:631904
      PTPc-N3; catalytic domain of tyrosine-protein phosphatase non-receptor type 3
    2. NM_011207.2NP_035337.2  tyrosine-protein phosphatase non-receptor type 3

      See identical proteins and their annotated locations for NP_035337.2

      Status: VALIDATED

      Source sequence(s)
      AL805921
      Consensus CDS
      CCDS51181.1
      UniProtKB/Swiss-Prot
      A2ALK8
      Related
      ENSMUSP00000075063.5, ENSMUST00000075637.11
      Conserved Domains (4) summary
      smart00295
      Location:31222
      B41; Band 4.1 homologues
      cd00992
      Location:508595
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13189
      Location:216309
      FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
      cd14600
      Location:631904
      PTPc-N3; catalytic domain of tyrosine-protein phosphatase non-receptor type 3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      57190841..57339036 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538097.5XP_006538160.1  tyrosine-protein phosphatase non-receptor type 3 isoform X1

      Conserved Domains (4) summary
      smart00295
      Location:53244
      B41; Band 4.1 homologues
      cd00992
      Location:530617
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13189
      Location:238331
      FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
      cd14600
      Location:653926
      PTPc-N3; catalytic domain of tyrosine-protein phosphatase non-receptor type 3
    2. XM_006538100.4XP_006538163.1  tyrosine-protein phosphatase non-receptor type 3 isoform X2

      See identical proteins and their annotated locations for XP_006538163.1

      UniProtKB/Swiss-Prot
      A2ALK8
      Conserved Domains (4) summary
      smart00295
      Location:31222
      B41; Band 4.1 homologues
      cd00992
      Location:508595
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13189
      Location:216309
      FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
      cd14600
      Location:631904
      PTPc-N3; catalytic domain of tyrosine-protein phosphatase non-receptor type 3
    3. XM_036164250.1XP_036020143.1  tyrosine-protein phosphatase non-receptor type 3 isoform X4

      Conserved Domains (3) summary
      cd00992
      Location:276363
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd14600
      Location:399672
      PTPc-N3; catalytic domain of tyrosine-protein phosphatase non-receptor type 3
      cl17171
      Location:177
      PH-like; Pleckstrin homology-like domain
    4. XM_006538099.4XP_006538162.1  tyrosine-protein phosphatase non-receptor type 3 isoform X2

      See identical proteins and their annotated locations for XP_006538162.1

      UniProtKB/Swiss-Prot
      A2ALK8
      Conserved Domains (4) summary
      smart00295
      Location:31222
      B41; Band 4.1 homologues
      cd00992
      Location:508595
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13189
      Location:216309
      FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
      cd14600
      Location:631904
      PTPc-N3; catalytic domain of tyrosine-protein phosphatase non-receptor type 3
    5. XM_006538101.4XP_006538164.1  tyrosine-protein phosphatase non-receptor type 3 isoform X3

      Conserved Domains (4) summary
      smart00295
      Location:291
      B41; Band 4.1 homologues
      cd00992
      Location:377464
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13189
      Location:85178
      FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
      cd14600
      Location:500773
      PTPc-N3; catalytic domain of tyrosine-protein phosphatase non-receptor type 3