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    Gnb1 guanine nucleotide binding protein (G protein), beta 1 [ Mus musculus (house mouse) ]

    Gene ID: 14688, updated on 3-Dec-2024

    Summary

    Official Symbol
    Gnb1provided by MGI
    Official Full Name
    guanine nucleotide binding protein (G protein), beta 1provided by MGI
    Primary source
    MGI:MGI:95781
    See related
    Ensembl:ENSMUSG00000029064 AllianceGenome:MGI:95781
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hg2a; Gnb-1
    Summary
    Predicted to enable several functions, including GTPase binding activity; alkylglycerophosphoethanolamine phosphodiesterase activity; and spectrin binding activity. Acts upstream of or within several processes, including phospholipase C-activating G protein-coupled receptor signaling pathway; retina development in camera-type eye; and sensory perception of taste. Located in photoreceptor outer segment. Part of heterotrimeric G-protein complex. Is active in synapse. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; autosomal dominant intellectual developmental disorder 42; congestive heart failure; and myelodysplastic syndrome. Orthologous to human GNB1 (G protein subunit beta 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 188.2), large intestine adult (RPKM 186.9) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Gnb1 in Genome Data Viewer
    Location:
    4 E2; 4 86.17 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (155575514..155643726)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (155491300..155559269)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 5830444B04 gene Neighboring gene cilia and flagella associated protein 74 Neighboring gene STARR-positive B cell enhancer ABC_E4738 Neighboring gene STARR-seq mESC enhancer starr_12263 Neighboring gene transmembrane protein 52 Neighboring gene NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 pseudogene Neighboring gene STARR-seq mESC enhancer starr_12266 Neighboring gene STARR-positive B cell enhancer ABC_E340 Neighboring gene STARR-positive B cell enhancer ABC_E10296 Neighboring gene NAD kinase Neighboring gene STARR-positive B cell enhancer ABC_E3559 Neighboring gene solute carrier family 35, member E2 Neighboring gene predicted gene 16023

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC98074

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables alkylglycerophosphoethanolamine phosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables signaling receptor complex adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables spectrin binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell body ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    part_of heterotrimeric G-protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of heterotrimeric G-protein complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of heterotrimeric G-protein complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in myelin sheath HDA PubMed 
    located_in photoreceptor inner segment ISO
    Inferred from Sequence Orthology
    more info
     
    located_in photoreceptor outer segment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in photoreceptor outer segment membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
    Names
    guanine nucleotide binding protein, beta 1
    heterotrimeric guanine nucleotide-binding protein 2a
    transducin beta chain 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001160016.2NP_001153488.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

      See identical proteins and their annotated locations for NP_001153488.1

      Status: VALIDATED

      Source sequence(s)
      AL627405, AL670227
      Consensus CDS
      CCDS19030.1
      UniProtKB/Swiss-Prot
      P62874
      UniProtKB/TrEMBL
      Q3TQ70, Q3U1B1
      Related
      ENSMUSP00000030940.8, ENSMUST00000030940.14
      Conserved Domains (2) summary
      cd00200
      Location:48340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:5895
      7WD40; WD40 repeat [structural motif]
    2. NM_001160017.2NP_001153489.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

      See identical proteins and their annotated locations for NP_001153489.1

      Status: VALIDATED

      Source sequence(s)
      AL627405, AL670227
      Consensus CDS
      CCDS19030.1
      UniProtKB/Swiss-Prot
      P62874
      UniProtKB/TrEMBL
      Q3TQ70, Q3U1B1
      Related
      ENSMUSP00000101241.4, ENSMUST00000105616.10
      Conserved Domains (2) summary
      cd00200
      Location:48340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:5895
      7WD40; WD40 repeat [structural motif]
    3. NM_001420967.2NP_001407896.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

      Status: VALIDATED

      Source sequence(s)
      AL627405, AL670227
      UniProtKB/Swiss-Prot
      P62874
      UniProtKB/TrEMBL
      Q3TQ70, Q3U1B1
      Related
      ENSMUSP00000135492.2, ENSMUST00000177094.8
    4. NM_001420968.1NP_001407897.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

      Status: VALIDATED

      Source sequence(s)
      AL627405, AL670227
      UniProtKB/Swiss-Prot
      P62874
      UniProtKB/TrEMBL
      Q3TQ70, Q3U1B1
    5. NM_001420969.1NP_001407898.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

      Status: VALIDATED

      Source sequence(s)
      AL627405, AL670227
      UniProtKB/Swiss-Prot
      P62874
      UniProtKB/TrEMBL
      Q3TQ70, Q3U1B1
    6. NM_001420970.1NP_001407899.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

      Status: VALIDATED

      Source sequence(s)
      AL627405, AL670227
      UniProtKB/Swiss-Prot
      P62874
      UniProtKB/TrEMBL
      Q3TQ70, Q3U1B1
      Related
      ENSMUSP00000135091.2, ENSMUST00000176637.2
    7. NM_001420971.1NP_001407900.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

      Status: VALIDATED

      Source sequence(s)
      AL627405, AL670227
      UniProtKB/Swiss-Prot
      P62874
      UniProtKB/TrEMBL
      Q3TQ70, Q3U1B1
    8. NM_008142.5NP_032168.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

      See identical proteins and their annotated locations for NP_032168.1

      Status: VALIDATED

      Source sequence(s)
      AL627405, AL670227
      Consensus CDS
      CCDS19030.1
      UniProtKB/Swiss-Prot
      P62874
      UniProtKB/TrEMBL
      Q3TQ70, Q3U1B1
      Related
      ENSMUSP00000130123.2, ENSMUST00000165335.8
      Conserved Domains (2) summary
      cd00200
      Location:48340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:5895
      7WD40; WD40 repeat [structural motif]

    RNA

    1. NR_185220.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL627405, AL670227
    2. NR_185221.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL627405, AL670227
    3. NR_185222.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL627405, AL670227
    4. NR_185223.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL627405, AL670227

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      155575514..155643726
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319977.2XP_017175466.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

      UniProtKB/Swiss-Prot
      P62874
      UniProtKB/TrEMBL
      Q3TQ70, Q3U1B1
      Conserved Domains (2) summary
      cd00200
      Location:48340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:5895
      7WD40; WD40 repeat [structural motif]