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    Jtb jumping translocation breakpoint [ Mus musculus (house mouse) ]

    Gene ID: 23922, updated on 9-Dec-2024

    Summary

    Official Symbol
    Jtbprovided by MGI
    Official Full Name
    jumping translocation breakpointprovided by MGI
    Primary source
    MGI:MGI:1346082
    See related
    Ensembl:ENSMUSG00000027937 AllianceGenome:MGI:1346082
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm622
    Summary
    Predicted to enable protein kinase binding activity. Involved in regulation of cell population proliferation. Acts upstream of or within apoptotic mitochondrial changes. Located in mitochondrion. Is expressed in several structures, including gallbladder; gut; male reproductive gland or organ; nervous system; and trachea. Orthologous to human JTB (jumping translocation breakpoint). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 59.3), duodenum adult (RPKM 37.9) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Jtb in Genome Data Viewer
    Location:
    3 F1; 3 39.21 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (90138904..90143147)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (90231597..90235840)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1624 Neighboring gene ribosomal protein S27 Neighboring gene RAB13, member RAS oncogene family Neighboring gene cAMP responsive element binding protein 3-like 4 Neighboring gene STARR-positive B cell enhancer ABC_E1265 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:90052523-90052632 Neighboring gene solute carrier family 39 (zinc transporter), member 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:90057967-90058076 Neighboring gene CREB regulated transcription coactivator 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (2) 

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic mitochondrial changes IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mitotic cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitotic cytokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic cytokinesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    colocalizes_with centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    colocalizes_with centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in midbody IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
     
    located_in midbody ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    colocalizes_with spindle ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with spindle ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_206924.2NP_996807.1  protein JTB precursor

      See identical proteins and their annotated locations for NP_996807.1

      Status: VALIDATED

      Source sequence(s)
      AK004469, BG077727, BY308991, BY617278
      Consensus CDS
      CCDS17523.1
      UniProtKB/Swiss-Prot
      O88824
      UniProtKB/TrEMBL
      Q3UJR4, Q542D4, Q9D0T9
      Related
      ENSMUSP00000029546.9, ENSMUST00000029546.15
      Conserved Domains (1) summary
      pfam05439
      Location:37143
      JTB; Jumping translocation breakpoint protein (JTB)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      90138904..90143147
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)