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    Arhgef11 Rho guanine nucleotide exchange factor 11 [ Mus musculus (house mouse) ]

    Gene ID: 213498, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Arhgef11provided by MGI
    Official Full Name
    Rho guanine nucleotide exchange factor 11provided by MGI
    Primary source
    MGI:MGI:2441869
    See related
    Ensembl:ENSMUSG00000041977 AllianceGenome:MGI:2441869
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Prg; RhoGEF; mKIAA0380; PDZ-RhoGEF
    Summary
    Predicted to enable G protein-coupled receptor binding activity and guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including Rho protein signal transduction; positive regulation of DNA-templated transcription; and positive regulation of L-glutamate import across plasma membrane. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including cardiovascular system; facial prominence ectoderm; genitourinary system; gut; and nervous system. Orthologous to human ARHGEF11 (Rho guanine nucleotide exchange factor 11). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 16.7), lung adult (RPKM 15.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Arhgef11 in Genome Data Viewer
    Location:
    3 F1; 3 38.22 cM
    Exon count:
    43
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (87524855..87645346)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (87617548..87738039)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene ets variant 3-like Neighboring gene predicted gene, 25167 Neighboring gene STARR-seq mESC enhancer starr_08160 Neighboring gene STARR-seq mESC enhancer starr_08161 Neighboring gene ribosomal protein S27 pseudogene Neighboring gene predicted gene 6570 Neighboring gene leucine rich repeat containing 71 Neighboring gene platelet endothelial aggregation receptor 1 Neighboring gene neurotrophic tyrosine kinase, receptor, type 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The Rho-guanine nucleotide exchange factor PDZ-RhoGEF governs susceptibility to diet-induced obesity and type 2 diabetes. Chang YJ, et al. Elife, 2015 Oct 29. PMID 26512886, Free PMC Article
    2. Rho GEF Lsc is required for normal polarization, migration, and adhesion of formyl-peptide-stimulated neutrophils. Francis SA, et al. Blood, 2006 Feb 15. PMID 16263795, Free PMC Article
    3. Rho GTP exchange factor ARHGEF11 regulates the integrity of epithelial junctions by connecting ZO-1 and RhoA-myosin II signaling. Itoh M, et al. Proc Natl Acad Sci U S A, 2012 Jun 19. PMID 22665792, Free PMC Article
    4. Arhgef1 Plays a Vital Role in Platelet Function and Thrombogenesis. Qasim H, et al. J Am Heart Assoc, 2019 May 7. PMID 30994039, Free PMC Article
    5. Direct interaction of p21-activated kinase 4 with PDZ-RhoGEF, a G protein-linked Rho guanine exchange factor. Barac A, et al. J Biol Chem, 2004 Feb 13. PMID 14625312

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the ablation of Esrp1 and Esrp2 impairs epithelial tight junction (TJ) integrity through loss of the epithelial isoform of Rho GTP exchange factor Arhgef11.
      Title: Esrp1-Regulated Splicing of Arhgef11 Isoforms Is Required for Epithelial Tight Junction Integrity.
    2. These results demonstrate that PDZ-RhoGEF acts as a key determinant of mammalian metabolism and obesity-associated pathologies.
      Title: The Rho-guanine nucleotide exchange factor PDZ-RhoGEF governs susceptibility to diet-induced obesity and type 2 diabetes.
    3. Agonist-induced Ca2+ sensitization in smooth muscle: redundancy of Rho guanine nucleotide exchange factors (RhoGEFs) and response kinetics, a caged compound study.
      Title: Agonist-induced Ca2+ sensitization in smooth muscle: redundancy of Rho guanine nucleotide exchange factors (RhoGEFs) and response kinetics, a caged compound study.
    4. PDZ-RhoGEF and LARG are essential for embryonic development and provide a link between thrombin and LPA receptors and Rho activation.
      Title: PDZ-RhoGEF and LARG are essential for embryonic development and provide a link between thrombin and LPA receptors and Rho activation.
    5. results suggest that ARHGEF11 mediates RhoA-myosin light chain signaling pathways at cell-cell junctions, functioning in cooperation with ZO-1
      Title: Rho GTP exchange factor ARHGEF11 regulates the integrity of epithelial junctions by connecting ZO-1 and RhoA-myosin II signaling.
    6. PDZ-RhoGEF interacts directly with p21-activated kinase 4 to negatively regulate the activation of Rho
      Title: Direct interaction of p21-activated kinase 4 with PDZ-RhoGEF, a G protein-linked Rho guanine exchange factor.
    7. Required for normal polarization, migration, and adhesion of formyl-peptide-stimulated neutrophils.
      Title: Rho GEF Lsc is required for normal polarization, migration, and adhesion of formyl-peptide-stimulated neutrophils.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (5)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • KIAA0380, MGC90827, B930073M02, E130307F09

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Rho protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of L-glutamate import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    rho guanine nucleotide exchange factor 11
    Names
    Rho guanine nucleotide exchange factor (GEF) 11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003912.3 → NP_001003912.1  rho guanine nucleotide exchange factor 11 isoform 1

      See identical proteins and their annotated locations for NP_001003912.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC139241, AC161454
      Consensus CDS
      CCDS38472.1
      UniProtKB/TrEMBL
      E9Q0A3, Q68FM7
      Related
      ENSMUSP00000039900.9, ENSMUST00000039476.15
      Conserved Domains (5) summary
      cd08753
      Location:330 → 474
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      COG0265
      Location:61 → 137
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:46 → 120
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:969 → 1111
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00621
      Location:768 → 952
      RhoGEF; RhoGEF domain

    2. NM_001360195.2 → NP_001347124.1  rho guanine nucleotide exchange factor 11 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences in the 5' coding region but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC139241, AC161454
      UniProtKB/TrEMBL
      E9Q0A3
      Related
      ENSMUSP00000118123.2, ENSMUST00000129113.8
      Conserved Domains (5) summary
      cd08753
      Location:290 → 434
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      smart00325
      Location:739 → 923
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:46 → 120
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:940 → 1082
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      cl26464
      Location:1071 → 1413
      Atrophin-1; Atrophin-1 family

    3. NM_001360197.2 → NP_001347126.1  rho guanine nucleotide exchange factor 11 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon in the 5' region and uses a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC139241, AC161454
      Conserved Domains (3) summary
      PHA03247
      Location:450 → 792
      PHA03247; large tegument protein UL36; Provisional
      cd13391
      Location:319 → 461
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00621
      Location:118 → 301
      RhoGEF; RhoGEF domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      87524855..87645346
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501264.2 → XP_006501327.1  rho guanine nucleotide exchange factor 11 isoform X1

      UniProtKB/TrEMBL
      E9Q0A3
      Conserved Domains (5) summary
      cd08753
      Location:346 → 490
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      PHA03247
      Location:1127 → 1469
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:62 → 136
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:996 → 1138
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00621
      Location:795 → 978
      RhoGEF; RhoGEF domain

    2. XM_006501272.2 → XP_006501335.1  rho guanine nucleotide exchange factor 11 isoform X13

      UniProtKB/TrEMBL
      E9Q0A3
      Conserved Domains (5) summary
      cd08753
      Location:346 → 490
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      PHA03307
      Location:1169 → 1536
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00992
      Location:62 → 136
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:996 → 1138
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00621
      Location:795 → 978
      RhoGEF; RhoGEF domain

    3. XM_006501267.2 → XP_006501330.1  rho guanine nucleotide exchange factor 11 isoform X4

      UniProtKB/TrEMBL
      E9Q0A3
      Conserved Domains (5) summary
      cd08753
      Location:346 → 490
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      PHA03247
      Location:1117 → 1459
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:62 → 136
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:986 → 1128
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00621
      Location:785 → 968
      RhoGEF; RhoGEF domain

    4. XM_006501265.2 → XP_006501328.1  rho guanine nucleotide exchange factor 11 isoform X2

      UniProtKB/TrEMBL
      E9Q0A3
      Conserved Domains (5) summary
      cd08753
      Location:346 → 490
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      PHA03247
      Location:1126 → 1468
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:62 → 136
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:995 → 1137
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00621
      Location:794 → 977
      RhoGEF; RhoGEF domain

    5. XM_006501268.2 → XP_006501331.1  rho guanine nucleotide exchange factor 11 isoform X5

      UniProtKB/TrEMBL
      E9Q0A3
      Conserved Domains (5) summary
      cd08753
      Location:346 → 490
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      PHA03247
      Location:1116 → 1458
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:62 → 136
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:985 → 1127
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00621
      Location:784 → 967
      RhoGEF; RhoGEF domain

    6. XM_036163000.1 → XP_036018893.1  rho guanine nucleotide exchange factor 11 isoform X18

      UniProtKB/TrEMBL
      E9Q0A3
      Conserved Domains (5) summary
      cd08753
      Location:346 → 490
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      smart00325
      Location:784 → 968
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      PHA03307
      Location:1158 → 1525
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00992
      Location:62 → 136
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:985 → 1127
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain

    7. XM_006501273.2 → XP_006501336.1  rho guanine nucleotide exchange factor 11 isoform X14

      UniProtKB/TrEMBL
      E9Q0A3
      Conserved Domains (5) summary
      cd08753
      Location:300 → 444
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      PHA03247
      Location:1081 → 1423
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:62 → 136
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:950 → 1092
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00621
      Location:749 → 932
      RhoGEF; RhoGEF domain

    8. XM_036163001.1 → XP_036018894.1  rho guanine nucleotide exchange factor 11 isoform X19

      UniProtKB/TrEMBL
      E9Q0A3
      Conserved Domains (5) summary
      cd08753
      Location:300 → 444
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      smart00325
      Location:739 → 923
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      PHA03247
      Location:1071 → 1413
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:62 → 136
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:940 → 1082
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain

    9. XM_006501270.2 → XP_006501333.1  rho guanine nucleotide exchange factor 11 isoform X11

      UniProtKB/TrEMBL
      E9Q0A3
      Conserved Domains (5) summary
      cd08753
      Location:306 → 450
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      PHA03247
      Location:1087 → 1429
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:62 → 136
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:956 → 1098
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00621
      Location:755 → 938
      RhoGEF; RhoGEF domain

    10. XM_006501274.2 → XP_006501337.1  rho guanine nucleotide exchange factor 11 isoform X15

      UniProtKB/TrEMBL
      E9Q0A3
      Conserved Domains (5) summary
      cd08753
      Location:306 → 450
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      PHA03247
      Location:1077 → 1419
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:62 → 136
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:946 → 1088
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00621
      Location:745 → 928
      RhoGEF; RhoGEF domain

    11. XM_006501271.2 → XP_006501334.1  rho guanine nucleotide exchange factor 11 isoform X12

      UniProtKB/TrEMBL
      E9Q0A3
      Conserved Domains (5) summary
      cd08753
      Location:306 → 450
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      PHA03247
      Location:1086 → 1428
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:62 → 136
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:955 → 1097
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00621
      Location:754 → 937
      RhoGEF; RhoGEF domain

    12. XM_011240067.1 → XP_011238369.1  rho guanine nucleotide exchange factor 11 isoform X16

      UniProtKB/TrEMBL
      E9Q0A3
      Conserved Domains (5) summary
      cd08753
      Location:306 → 450
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      PHA03247
      Location:1076 → 1418
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:62 → 136
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:945 → 1087
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00621
      Location:744 → 927
      RhoGEF; RhoGEF domain

    13. XM_006501266.2 → XP_006501329.1  rho guanine nucleotide exchange factor 11 isoform X3

      UniProtKB/TrEMBL
      E9Q0A3
      Conserved Domains (5) summary
      cd08753
      Location:341 → 485
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      PHA03247
      Location:1122 → 1464
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:57 → 131
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:991 → 1133
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00621
      Location:790 → 973
      RhoGEF; RhoGEF domain

    14. XM_036162998.1 → XP_036018891.1  rho guanine nucleotide exchange factor 11 isoform X6

      UniProtKB/TrEMBL
      E9Q0A3
      Conserved Domains (5) summary
      cd08753
      Location:341 → 485
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      smart00325
      Location:780 → 964
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      PHA03247
      Location:1112 → 1454
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:57 → 131
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:981 → 1123
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain

    15. XM_030252534.1 → XP_030108394.1  rho guanine nucleotide exchange factor 11 isoform X8

      UniProtKB/TrEMBL
      E9Q0A3
      Conserved Domains (5) summary
      cd08753
      Location:341 → 485
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      PHA03247
      Location:1111 → 1453
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:57 → 131
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:980 → 1122
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00621
      Location:779 → 962
      RhoGEF; RhoGEF domain

    16. XM_030252536.1 → XP_030108396.1  rho guanine nucleotide exchange factor 11 isoform X17

      UniProtKB/TrEMBL
      E9Q0A3
      Conserved Domains (5) summary
      cd08753
      Location:295 → 439
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      PHA03247
      Location:1076 → 1418
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:57 → 131
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:945 → 1087
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00621
      Location:744 → 927
      RhoGEF; RhoGEF domain

    17. XM_006501269.2 → XP_006501332.1  rho guanine nucleotide exchange factor 11 isoform X7

      UniProtKB/TrEMBL
      E9Q0A3
      Conserved Domains (5) summary
      cd08753
      Location:330 → 474
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      PHA03247
      Location:1111 → 1453
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:46 → 120
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:980 → 1122
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00621
      Location:779 → 962
      RhoGEF; RhoGEF domain

    18. XM_036162999.1 → XP_036018892.1  rho guanine nucleotide exchange factor 11 isoform X10

      UniProtKB/TrEMBL
      E9Q0A3
      Conserved Domains (5) summary
      cd08753
      Location:330 → 474
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      smart00325
      Location:769 → 953
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      PHA03247
      Location:1101 → 1443
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:46 → 120
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:970 → 1112
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain

    19. XM_030252535.1 → XP_030108395.1  rho guanine nucleotide exchange factor 11 isoform X9

      UniProtKB/TrEMBL
      E9Q0A3
      Conserved Domains (5) summary
      cd08753
      Location:330 → 474
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      PHA03247
      Location:1110 → 1452
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:46 → 120
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:979 → 1121
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00621
      Location:778 → 961
      RhoGEF; RhoGEF domain

    20. XM_030252537.1 → XP_030108397.1  rho guanine nucleotide exchange factor 11 isoform X20

      UniProtKB/TrEMBL
      E9Q0A3
      Conserved Domains (5) summary
      cd08753
      Location:284 → 428
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      PHA03247
      Location:1065 → 1407
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:46 → 120
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:934 → 1076
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00621
      Location:733 → 916
      RhoGEF; RhoGEF domain

    21. XM_030252538.1 → XP_030108398.1  rho guanine nucleotide exchange factor 11 isoform X21

      Conserved Domains (3) summary
      PHA03247
      Location:450 → 792
      PHA03247; large tegument protein UL36; Provisional
      cd13391
      Location:319 → 461
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00621
      Location:118 → 301
      RhoGEF; RhoGEF domain

    RNA

    1. XR_004941301.1 RNA Sequence

      Related
      ENSMUST00000152006.2
    Nucleotide Protein Strain
    Heading Accession and Version

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