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    Mppe1 metallophosphoesterase 1 [ Mus musculus (house mouse) ]

    Gene ID: 225651, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mppe1provided by MGI
    Official Full Name
    metallophosphoesterase 1provided by MGI
    Primary source
    MGI:MGI:2661311
    See related
    Ensembl:ENSMUSG00000062526 AllianceGenome:MGI:2661311
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pgap5
    Summary
    Predicted to enable GPI anchor binding activity; GPI-mannose ethanolamine phosphate phosphodiesterase activity; and manganese ion binding activity. Predicted to be involved in GPI anchor biosynthetic process and endoplasmic reticulum to Golgi vesicle-mediated transport. Predicted to be located in several cellular components, including cis-Golgi network; endoplasmic reticulum exit site; and endoplasmic reticulum-Golgi intermediate compartment. Orthologous to human MPPE1 (metallophosphoesterase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in cortex adult (RPKM 18.8), spleen adult (RPKM 10.2) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mppe1 in Genome Data Viewer
    Location:
    18 E1; 18 39.9 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (67358119..67378901, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (67225043..67245830, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene guanine nucleotide binding protein, alpha stimulating, olfactory type Neighboring gene predicted gene, 23512 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:67372131-67372603 Neighboring gene charged multivesicular body protein 1B Neighboring gene STARR-positive B cell enhancer ABC_E9173 Neighboring gene STARR-seq mESC enhancer starr_44880 Neighboring gene STARR-positive B cell enhancer ABC_E7602 Neighboring gene STARR-positive B cell enhancer mm9_chr18:67448542-67448843 Neighboring gene STARR-seq mESC enhancer starr_44887 Neighboring gene predicted gene, 30321 Neighboring gene inositol monophosphatase 2 Neighboring gene RIKEN cDNA B430212C06 gene Neighboring gene STARR-positive B cell enhancer ABC_E10999 Neighboring gene cell death-inducing DNA fragmentation factor, alpha subunit-like effector A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GPI anchor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables GPI-mannose ethanolamine phosphate phosphodiesterase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables manganese ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in GPI anchor biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cis-Golgi network ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum exit site ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    metallophosphoesterase 1
    Names
    post-GPI attachment to proteins factor 5
    NP_001344447.1
    NP_766218.1
    XP_011245209.1
    XP_011245210.1
    XP_011245211.1
    XP_011245212.1
    XP_011245213.1
    XP_011245214.1
    XP_011245215.1
    XP_030106302.1
    XP_030106303.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357518.1 → NP_001344447.1  metallophosphoesterase 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC140336, BM898884
      UniProtKB/Swiss-Prot
      Q3T9I6, Q3TYP9, Q3U4F5, Q80XL7, Q8BLU5
      Conserved Domains (1) summary
      cd08165
      Location:71 → 329
      MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain

    2. NM_172630.3 → NP_766218.1  metallophosphoesterase 1 isoform 1

      See identical proteins and their annotated locations for NP_766218.1

      Status: VALIDATED

      Source sequence(s)
      AC140336, AK041262, BM898884
      Consensus CDS
      CCDS29319.1
      UniProtKB/Swiss-Prot
      Q80XL7
      Related
      ENSMUSP00000072808.4, ENSMUST00000073054.5
      Conserved Domains (1) summary
      cd08165
      Location:71 → 330
      MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      67358119..67378901 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011246910.4 → XP_011245212.1  metallophosphoesterase 1 isoform X2

      Conserved Domains (1) summary
      cd08165
      Location:71 → 352
      MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain

    2. XM_011246911.4 → XP_011245213.1  metallophosphoesterase 1 isoform X5

      See identical proteins and their annotated locations for XP_011245213.1

      Conserved Domains (1) summary
      cl13995
      Location:19 → 282
      MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain

    3. XM_011246907.4 → XP_011245209.1  metallophosphoesterase 1 isoform X1

      See identical proteins and their annotated locations for XP_011245209.1

      Conserved Domains (1) summary
      cd08165
      Location:71 → 353
      MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain

    4. XM_030250442.2 → XP_030106302.1  metallophosphoesterase 1 isoform X3

      Conserved Domains (1) summary
      cd08165
      Location:71 → 330
      MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain

    5. XM_030250443.2 → XP_030106303.1  metallophosphoesterase 1 isoform X4

      UniProtKB/Swiss-Prot
      Q3T9I6, Q3TYP9, Q3U4F5, Q80XL7, Q8BLU5
      Conserved Domains (1) summary
      cd08165
      Location:71 → 329
      MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain

    6. XM_011246913.4 → XP_011245215.1  metallophosphoesterase 1 isoform X5

      See identical proteins and their annotated locations for XP_011245215.1

      Conserved Domains (1) summary
      cl13995
      Location:19 → 282
      MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain

    7. XM_011246909.4 → XP_011245211.1  metallophosphoesterase 1 isoform X1

      See identical proteins and their annotated locations for XP_011245211.1

      Conserved Domains (1) summary
      cd08165
      Location:71 → 353
      MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain

    8. XM_011246912.3 → XP_011245214.1  metallophosphoesterase 1 isoform X5

      See identical proteins and their annotated locations for XP_011245214.1

      Conserved Domains (1) summary
      cl13995
      Location:19 → 282
      MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain

    9. XM_011246908.3 → XP_011245210.1  metallophosphoesterase 1 isoform X1

      See identical proteins and their annotated locations for XP_011245210.1

      Conserved Domains (1) summary
      cd08165
      Location:71 → 353
      MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain

    RNA

    1. XR_003952516.1 RNA Sequence

    2. XR_003952517.1 RNA Sequence

    3. XR_003952518.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80XL7.1 GenPept UniProtKB/Swiss-Prot:Q80XL7

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